Niaoduqing Granule consists of Radix et Rhizoma Rhei, Radix Astragali, Cortex Mori, Radix Sophorae Flavescentis, Atractylodis Rhizoma, Poria, Radix Paeoniae Alba, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Herba Plantaginis, etc. It has the effects of dredging fu-organs, reducing turbidity, invigorating spleen, promoting diuresis, promoting blood circulation and removing blood stasis. It can be used for chronic renal failure, azotemia's stage and early uremia, and TCM syndrome differentiation belongs to spleen deficiency and dampness turbidity syndrome and spleen deficiency and blood stasis syndrome. It can reduce creatinine and urea nitrogen, stabilize renal function, delay dialysis time, improve renal anemia, increase blood calcium and reduce blood phosphorus.
Studies have shown that Niaoduqing Granule can reduce the reabsorption of intestinal ammonia, inhibit the synthesis of urea and increase the excretion of urea and creatinine, so it can directly reduce urea nitrogen and creatinine. It can also delay the progress of renal failure and reduce complications by inhibiting inflammatory reaction, reducing urinary protein and preventing glomerular sclerosis and renal interstitial fibrosis. It can also improve lipid metabolism disorder, regulate immunity, improve micro-inflammatory state and reduce the risk of cardiovascular events in patients with chronic kidney disease.
For non-dialysis patients with chronic kidney disease in stage 3-5, on the basis of standardized treatment of western medicine, it is suggested to combine Niaoduqing Granules, which can further reduce the serum creatinine level, prevent the decline of glomerular filtration rate, reduce the 24-hour urine protein quantification and delay the progress of kidney disease. It is mainly suitable for this kind of patients who will feel weak body weight, loss of appetite, nausea and vomiting, abdominal distension, numbness of limbs and greasy tongue (spleen deficiency, dampness and turbidity, blood stasis syndrome). Use with caution in patients in loose stool.
Shenshuaining Capsule consists of Radix Salviae Miltiorrhizae, Radix et Rhizoma Rhei, Radix Pseudostellariae, Coptidis Rhizoma, Achyranthis Radix, Rhizoma Pinelliae (processed), Carthami Flos, Poria, Pericarpium Citri Tangerinae and Glycyrrhrizae Radix. It has the effects of invigorating qi, invigorating spleen, promoting blood circulation, removing blood stasis, dredging fu-organs and removing turbidity. It can be used for treating lumbago, fatigue, sallow complexion, nausea and vomiting, loss of appetite, dysuria, sticky stool and chronic renal insufficiency caused by various reasons.
Modern pharmacological studies have confirmed that Pseudostellaria heterophylla in Shenshuaining capsule is rich in vitamins, polysaccharides, saponins and amino acids, and has the functions of enhancing immunity, resisting lipid peroxidation and protecting renal function. Poria polysaccharide in Poria cocos can activate cellular immunity, enhance antigen clearance and repair glomerular basement membrane damage. Salvia Miltiorrhiza and Carthamus tinctorius have the effects of enhancing immunity, reducing renal tubular resistance and improving renal blood circulation, thus delaying renal failure.
In addition, rhubarb, safflower, salvia miltiorrhiza and pseudostellaria heterophylla can reduce blood lipid, and then regulate plasma volume, which has a positive effect on improving renal function. Moreover, rhubarb can also inhibit mesangial hyperplasia and reduce the high metabolic state and oxygen consumption of residual renal units, thus delaying or alleviating renal interstitial lesions and glomerulosclerosis, and delaying the process of renal damage from physiology and histomorphology.
For non-dialysis patients with chronic kidney disease in stage 3-5, Shenshuaining capsule can be combined on the basis of standardized treatment of western medicine, which can further reduce serum creatinine level, increase creatinine clearance rate, reduce 24-hour urine protein quantification and improve renal function. It is suitable for patients with chronic kidney disease with dry stool, and should be used with caution for patients with loose stool, abdominal distension and epigastric cold (spleen and stomach deficiency). It is not recommended to use it with other preparations containing rhubarb.
The main component of Haikun Shenxi Capsule is fucoidan. It has the effects of removing turbidity and toxic materials, promoting diuresis and reducing swelling. Fucoidan sulfate is a polysaccharide compound refined from seaweed extract by introducing effective genes. Similar to heparin, it not only has the functions of anticoagulation, anti-platelet aggregation and improving hemorheology, but also has the function of rebuilding the negative charge barrier of injured glomerular basement membrane, preventing mesangial matrix from expanding and basement membrane from proliferating, thus reducing the amount of urine protein and protecting renal function.
In addition, hyperlipidemia is common in patients with renal failure, and the increased blood lipid can be deposited on the glomerular basement membrane, causing glomerular damage, stimulating glomerular mesangial cells and smooth muscle cells, accelerating the deterioration of renal function and arteriosclerosis of renal vessels. Fucoidan sulfate can effectively reduce total cholesterol and triglyceride, which has a positive effect on the prevention and treatment of renal failure.
Pharmacodynamic tests show that this product can reduce serum creatinine and urea nitrogen levels, increase serum albumin content and improve renal tissue morphology in renal failure rats. It has inhibitory effect on delayed hypersensitivity induced by 2,4-dinitrochlorobenzene in mice, diuretic effect on normal and water-loaded rats, and can increase renal blood flow in anesthetized dogs.
It is suitable for chronic renal failure (compensatory period, decompensated period and early uremia) with damp and turbid syndrome, with symptoms of nausea, vomiting, anorexia, abdominal distension, heavy weight and drowsiness, scanty urine, edema and thick and greasy fur. Use with caution in patients with loose stool (spleen and kidney deficiency).