Improve the capillaries
Rutin can improve the function of the capillaries, to maintain the normal resistance of the capillaries, to prevent bleeding due to capillary brittleness is too large, caused by excessive osmosis, hypertension, diabetes, serving can prevent bleeding.
Treatment of blood in stool
So Sophora japonica is mostly used as a common medicine for the treatment of blood in stool, which is used for hemorrhoidal bleeding caused by damp-heat in the large intestine, hemorrhoidal bleeding, bloody diarrhea and vomiting blood and epistaxis caused by blood heat. It is usually decocted, 10-15g, and used externally in appropriate amounts, with caution for those with cold spleen and stomach and yin deficiency and fever without actual fire.
Effects on cardiovascular system
Sophora liquid has mild excitatory effect on isolated frog heart, and has blocking effect on cardiac conduction system. Rutoside, quercetin, quercetin can also increase the contraction and output of isolated and in situ frog heart, and can slow down the heart rate. Quercetin can dilate coronary blood vessels, improve myocardial circulation. Rutoside can make the lower limbs of toad and rabbit ear vasoconstriction.
Effect on blood lipids
Quercetin can effectively reduce the amount of cholesterol in the liver, aorta and blood, and increase the stability of cholesterol-protein complexes, experimental atherosclerosis has preventive and therapeutic effects. Subcutaneous injection of quercetin 10mg can effectively reduce the amount of cholesterol in the liver, aorta and blood of experimental hypercholesterolemia rats, and increase the stability of cholesterol-protein complex. It has preventive and therapeutic effects on experimental atherosclerosis.
Effects of Sophora japonica on capillaries
Rutinoside and its glycoside quercetin can maintain the normal resistance of capillaries, reduce vascular permeability, and restore the normal elasticity of capillaries that have bled due to increased brittleness. Quercetin can enhance the resistance of skin capillaries of guinea pigs and rats, reduce vascular permeability, and its stability of capillaries is 1/3 stronger than that of rue glucoside. continuous application of large quantities of rue glucoside and quercetin can prevent lung hemorrhage due to decompression of rats.
Anti-inflammatory effect
Sophora contains rutinoside, sophora diol, glucose and glucuronic acid and tannin, anti-inflammatory effect, the same inhibitory effect on viruses and skin fungi.
Antispasmodic, antiulcer effects
Quercetin can reduce intestinal and bronchial smooth muscle tone, its antispasmodic effect than rue glucoside 5 times stronger, with X-ray studies have proved that, rue glucoside can reduce gastric motility in rats, and can relieve barium chloride-induced spasm of the small intestinal smooth muscle, the efficacy of only 1/14 of the kelin, subcutaneous injection of rue glucoside 5-10 mg / kg, can significantly reduce the rats The number of foci of gastric ulcers caused by ligation of the pylorus, the effectiveness of reflex gastric ulcers is stronger than Kailin. Sophora liquid (containing little rutinoside) injected into the intestinal lumen of rabbits, can stimulate the intestinal mucosa so that the increase in exudate.
Coronary expansion, hypotensive, hypolipidemic
Acacia flower liquid, acacia flower tincture on anesthetized dogs and cats have a significant temporary lowering effect of blood pressure. Rutin, quercetin and their preparations have antihypertensive effects.
Anti-mature pregnancy
Sophora rice genistein and kaempferol have the effect of terminating the implantation of the pregnant egg and resisting early pregnancy in mice. This may be related to their estrogenic activity.
Other effects
Rutinosides and quercetin have antimicrobial effects against certain bacteria in the test tube, and are also thought to have no antimicrobial effect. For viruses, fungi in vitro also showed inhibition. Rutoside on rat sarcoma-45 and mouse lung adenoma have no inhibitory effect, but Japanese scholars believe that some tumors have inhibitory effect. Both have effects on a variety of enzymes. In addition, rue glucoside has a protective effect on X-ray irradiation (the residual rate of mice is higher than the control group), and can make the lethal dose of Nitroxin received by the mice to reduce the mortality rate. Sophora contains hemagglutinin, which has an agglutinating effect on blood cells. Large doses of acacia tincture caused inhibition of certain central reflex functions.