Human immune system 1, immune barrier: skin, mucosa, blood-brain barrier, blood-fetal barrier. It forms the first barrier for the human body to defend against carcinogens and carcinogenic factors. 2. Immune organs: thymus, lymph and bone marrow. 3. Immune cells: T lymphocytes, B lymphocytes, NK cells and macrophages. Immune substances: antibody, lysozyme, lymphatic factor, etc.
About the constant metabolism of cancer cells, abnormal cell proliferation will be formed every time. Repeated cell proliferation caused cell gene mutation, and cancer cells were formed under the action of carcinogens. Under normal circumstances, the body's immune system will monitor and destroy these cancer cells and get rid of them in time. However, in order to avoid the pursuit of human immune system, cancer cells hide their specific antigens.
So that the human immune system can't recognize it, and it can't be killed to form cancer. In addition, cancer cells can directly inhibit the immune function of the human body through various channels, and even use the immune system of the human body to make immune cells become the enemies of cancer and help cancer cells replicate and metastasize. Therefore, we used cyclophosphamide, an anti-tumor immunosuppressant, to control the development of cancer in our early years.
Once cancer is found in clinic, it is almost impossible to cure cancer by enhancing human immunity. At present, according to the escape characteristics of cancer cells, immune T cells are separated from patients by genetic modification, and a cell that can recognize tumors is added to T cells by genetic engineering, and at the same time, T cells are activated to kill chimeras of tumor cells, thus having the ability to automatically recognize cancer cells.
Find cancer cells and launch suicide attacks. This therapy is called CAR-T cell therapy. Another immunosuppressant, PD-1 1 and PD-11,enhanced the recognition and killing ability of T cells and achieved a breakthrough in the treatment of some advanced tumors.
Conclusion Improving immunity for tumor prevention and rehabilitation is supported in theory and strongly advocated. Cancer has been formed or reached the advanced stage. Before 1990s, cyclophosphamide, an immunosuppressant, was used to control the tumor. Moreover, at present, no scholar at home and abroad advocates using drugs to improve immunity to treat tumors.