Huang (1929-), male, Han nationality, from Nantong, Jiangsu. Professor and chief physician of Shanghai University of Traditional Chinese Medicine.
Chinese name: Huang.
Nationality: China.
Ethnic group: Han nationality
Place of birth: Nantong, Jiangsu
Date of birth: 1929
Occupation: University professor, chief physician.
Graduate school: Beijing Medical College
Main achievements: 1997 was awarded as a famous old Chinese medicine practitioner in Shanghai.
Masterpieces: Clinical Manual of Internal Medicine of Traditional Chinese Medicine, Manual of Modern Internal Medicine of Traditional Chinese Medicine and clinical internal medicine of Traditional Chinese Medicine.
Character experience
Mr. Wang was born in a family of traditional Chinese medicine. When he was a teenager, he learned from his father the procurement, processing and formulation of Chinese medicine, and became interested in Chinese medicine. It was deeply influenced by the famous doctor Ding. Graduated from 1949, hanging pot in Donggou Town, Pudong. During his medical career, he deeply felt that the motherland's medical treasure house was extensive and profound, but for a long time, it was mostly passed down from generation to generation with experience, lacking systematic and in-depth research. If this situation is not changed, it is difficult for Chinese medicine to develop and break through. So 1952 was admitted to Beijing Medical College for further study. 1957 After graduation, I worked in Shanghai Eleventh People's Hospital (later changed to Shuguang Hospital). During this period, under the guidance of my predecessors, such as Tong, Zhang, Zhang, etc., I studied medical classics intensively, learned from others' strengths, combined Chinese and western, made constant breakthroughs and made unremitting efforts. Since 1950s, under the guidance of Mr. Tong, the treatment of chronic nephritis and uremia with integrated traditional Chinese and western medicine has been discussed, and he participated in the compilation of the book Theory and Treatment of Chronic Nephritis in Traditional Chinese Medicine. In the mid-1960s, he participated in the research and development of Yinhuang tablets and anti-inflammatory drugs in first aid work. Since the 1970s, he has devoted himself to the clinical and research of lung diseases such as chronic bronchitis and bronchial asthma. From 76 to 78, he participated in the observation of macrophages in bullous fluid of patients with chronic bronchitis by scanning electron microscope, and from 74 to 78, he participated in the guiding research of "using modern scientific methods to study the theory of Yin and Yang in traditional Chinese medicine". And the "Clinical and Experimental Study of Kidney Deficiency Essence and Bushen Yiqi Drugs for Chronic Bronchitis" hosted by 87-90. In addition to clinical and scientific research, I have been teaching undergraduate and graduate students for a long time, focusing on inspiring students to think, integrating theory with practice, and enriching decades of clinical experience and research results into the teaching of internal medicine of traditional Chinese medicine. He has compiled books such as Clinical Manual of Internal Medicine of Traditional Chinese Medicine, Manual of Modern Internal Medicine of Traditional Chinese Medicine and clinical internal medicine of Traditional Chinese Medicine. , published papers in provincial and municipal magazines 12, and published 65 papers in hospital research papers. Mr. Wang also instructed four graduate students and four academic heirs to study, and trained a group of successors with rigor and enthusiasm, making contributions to the cause of Chinese medicine. Teacher Wang is the tutor of the second Shanghai and the second national famous traditional Chinese medicine academic experience inheritance class, and was named as a famous old Chinese medicine practitioner in Shanghai from 65438 to 0997.
Honor achievement
He has successively compiled books such as Clinical Manual of Internal Medicine of Traditional Chinese Medicine, Manual of Modern Internal Medicine of Traditional Chinese Medicine and Clinical Internal Medicine, published papers 12 in provincial and municipal magazines, published papers 12 in hospital research papers, participated in international and regional academic exchanges of traditional Chinese medicine for 4 times, and took the stage to read papers. In addition to clinical and scientific research, he has been engaged in undergraduate and postgraduate teaching for a long time, focusing on inspiring students to think, integrating theory with practice, and enriching decades of clinical experience and research results into the teaching of internal medicine of traditional Chinese medicine.
Academic viewpoint
Kidney deficiency is the essence of chronic bronchitis and asthma.
Chronic bronchitis and asthma are characterized by recurrent attacks. Asthma has a lasting root, often due to congenital deficiency of kidney qi. Chronic bronchitis is more common in the elderly, and it is difficult to cure for a long time. Therefore, although cough, expectoration, wheezing and wheezing are the main lung symptoms, their essence lies in kidney deficiency. According to Neijing, the qi of chronic bronchitis will be deficient when pathogenic factors are combined. Through research, Mr. Wang found that kidney deficiency objectively manifested as a significant decline in sex hormone level, cellular immune function and pulmonary ventilation function, and modern research also confirmed that asthma patients had "hidden kidney deficiency syndrome" (that is, hypothalamus-pituitary-adrenal cortex function was low) regardless of whether there was kidney deficiency witness. This is the root of recurrent disease. Therefore, for patients with chronic bronchitis and asthma, it is the key to improve the curative effect by tonifying kidney and benefiting qi in the protracted period and remission period. According to the theory of "golden water and gold", "nourishing soil and producing gold" and "harmonizing essence and qi", epimedium, Cynomorium songaricum, Dipsacus asperoides, warming kidney and helping yang are the main drugs to cure the disease, and Mahonia leaves are added to nourish lung and spleen and yin, while Codonopsis pilosula and Astragalus membranaceus are added to invigorate spleen and qi, and the whole prescription warms yang and tonifies kidney, which is warm but not dry, and the yin is in the middle. For patients with yin deficiency, Radix Rehmanniae, Fructus Ligustri Lucidi and Mahonia leaves are the main ingredients, nourishing yin and tonifying kidney, supplemented by Herba Epimedii, Radix Dipsaci to warm kidney and help yang, and Radix Astragali and Radix Angelicae Sinensis to replenish qi and blood. The whole prescription nourishes yin, tonifies kidney and tonifies qi, but it is not greasy. Yin seeks in Yang, and essence and qi coexist. The two prescriptions can not only restore kidney essence, but also strengthen spleen and nourish lung, restore healthy qi, reduce the attack of expectoration and asthma, and relieve the disease until it is eliminated. Syndrome Differentiation and Treatment of Yin Deficiency and Phlegm Obstruction
Mr. Wang thinks that phlegm-drinking disease is mostly "yang deficiency and yin excess" in the early stage, but due to long-term cough, a large amount of phlegm is discharged and body fluid is consumed for a long time; Or because of phlegm and blood stasis and internal heat, body fluid is consumed; Or body fluid loss due to repeated feeling of wind-heat or dryness-heat; Or because of frequent use of hormones or antiasthmatic drugs, it produces the image of yin deficiency and fire flourishing; Therefore, phlegm-drinking disease lasts for a long time, which may be deficiency of both qi and yin, or deficiency of both yin and yang, and there is internal resistance to phlegm-drinking. Mr. Wang calls this kind of symptoms "yin deficiency and phlegm retention syndrome". The common symptoms are: chronic cough with asthma, cough with more or less phlegm, poor or easy cough, asthma, loss of appetite, dry mouth and dislike of hot drinks, rotten stool, or diarrhea with cold and heat, spontaneous sweating and night sweats; The moss is thin and thin, with little moss or fluid, light or dark red tongue, cracks and thin and thin pulse. Among them, tongue quality and tongue coating are the key points of syndrome differentiation of yin deficiency and phlegm drink. The treatment should be invigorating qi and nourishing yin, resolving phlegm and dispersing lung, and the pulse-door-winter soup and zetang-qi in synopsis of golden chamber should be modified. Commonly used drugs: Ophiopogon japonicus, Ginseng, Adenophora adenophora, Rhizoma Pinelliae Preparata, Euphorbia helioscopia, Rhizoma Cynanchi Stauntonii, Radix Asteris and Flos Farfarae. If accompanied by shortness of breath and wheezing, Rhizoma Belamcandae and Herba Ephedrae can be added; If accompanied by excessive phlegm, Perilla frutescens and Semen Sinapis Albae can be added; If phlegm is not smooth, bamboo juice and clam can be added; If accompanied by cough, Stemona and Tianzhu are added; Scutellariae Radix and Bupleuri Radix are added for phlegm-heat syndrome; Yin injury plus lily and radix rehmanniae; Dai Na loose stool plus Atractylodis Rhizoma, Poria and Rhizoma Dioscoreae; Saviae Miltiorrhizae Radix, Radix Curcumae, etc. Teacher Wang believes that this syndrome is mixed with excess and deficiency, so we should not use a lot of nourishing yin and greasy products because of yin deficiency, but use products that are sweet and cold, nourishing yin, strengthening the spleen and promoting fluid production, so that the spleen and body fluid can be transported normally, the lung and body fluid can be recovered, and phlegm and fluid can be absorbed.
Experience of syndrome differentiation and treatment
Diagnosis and treatment of cough.
Cough is one of the main symptoms of lung diseases. Cough syndrome differentiation first points to exogenous internal injury. Exogenous cough, which originates from violence, has six-qi syndrome; Cough due to internal injuries is mostly accumulated gradually, and every time there is a syndrome of five evils combined with five internal organs; Cough syndrome differentiation, cough sound is clear and turbid, phlegm color is qualitative, and it is divided into deficiency and excess, cold and heat; However, people who cough for a long time are often mixed with cold and heat, so they should be diagnosed by four methods and judged correctly. The key to treating cough: to treat exogenous cough, the medicine can't be static, and static will keep evil; Cough due to internal injury, inappropriate medication, and weak fire rising. Avoid warm and dry, robbing yin, bitter and cold, nourishing greasy products. Second, it is important to protect the spleen and stomach in treating phlegm.
Mr. Chang Yun: "Those who treat phlegm and drink but not spleen and stomach are not treated by it." The production of phlegm drink is related to the imbalance of lung, spleen and kidney function. Repeated cough and asthma, lung, spleen and kidney deficiency. Regular use of various drugs will damage the spleen and stomach, often leading to anorexia, abdominal distension, belching, loose stool and other symptoms. Therefore, before treatment, patients should be carefully asked about their diet and defecation, so as to check the status of spleen and stomach. The spleen and stomach are mainly regulated by four gentlemen, and those with excessive phlegm are added with Magnolia Officinalis, Pericarpium Citri Tangerinae, Rhizoma Pinelliae and Rhizoma Atractylodis. If qi stagnation is not smooth, add fried chicken gizzard-membrane, radish pod and burnt hawthorn koji to eliminate food accumulation; Spleen yang deficiency, stomach cold deficiency and cold, burnout loose stool Jializhong Pill warms up Zhongyang; The liver and stomach are full of fire, belching and pantothenic acid, and Coptidis Rhizoma, Evodia rutaecarpa and cuttlebone are added to reduce reflux; Gaza Ginseng, Ophiopogon japonicus, Polygonatum odoratum, Radix Paeoniae Alba, etc. Deficiency of stomach yin, dull stomachache, dry mouth and throat, and dry stool. In the treatment, we should pay attention to the following aspects: 1) When pathogenic factors are excessive and the function of spleen and stomach is weakened, we should deal with them urgently, try to avoid taking drugs that can relieve stomach qi, or supplement drugs that strengthen spleen and stomach properly; 2) Although the pathogenic factors are excessive, when the stomach qi is seriously injured, it is mainly to regulate the spleen, supplemented by eliminating pathogenic factors, strengthen the spleen and stomach, replenish qi and blood, and restore healthy qi to achieve evil; 3) Strengthening the body resistance and eliminating pathogenic factors in the protracted period, starting with supporting the spleen, and benefiting qi, strengthening the spleen and tonifying the kidney in the remission period.
Third, it is helpful to treat phlegm, regulate qi and promote blood circulation.
Cough recurs, lung qi is blocked, phlegm and qi are mixed, and qi stagnation and blood stasis cannot be cured for a long time. In clinical practice, common patients have dark tongue, or ecchymosis, black lips, chest tightness and pain. Later, due to excessive phlegm, weak heart yang and impassable heart pulse, cyanosis appeared on the face, lips, tongue and nails, and even dyspnea, sweating and disharmony between yin and yang. Therefore, when the methods of treating cough, relieving asthma, resolving phlegm, relieving asthma and strengthening body resistance are applied, the products of regulating qi and blood, promoting blood circulation and removing blood stasis can be added. This is to treat phlegm first, qi can be eliminated by itself, and qi can also promote blood circulation. Early application is helpful to the divergence of lung qi, and the qi can rise and fall normally, which can prevent the disease from prolonging; After later application, qi and blood circulation and viscera function can be maintained normally. In recent years, domestic research shows that the method of promoting blood circulation and removing blood stasis can improve microcirculation, increase blood flow, improve blood supply of lung tissue, correct abnormal hemorheology and prevent emphysema and cor pulmonale. The products for regulating qi can be Fructus Aurantii Immaturus, Fructus Aurantii Immaturus, Cortex Magnolia Officinalis, Pericarpium Citri Tangerinae, Rhizoma Cyperi, Lignum Aquilariae Resinatum, Lignum Dalbergiae Odoriferae, etc. The products for promoting blood circulation can be Radix Salviae Miltiorrhizae, Curcuma Rhizome, Semen Persicae, Carthami Flos, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Achyranthis Radix, Cortex Moutan, etc.
Medication characteristics
First, make good use of Long Ping to relieve cough.
Pheretima is salty, cold, cathartic and has the effect of relieving asthma and dredging collaterals. Mr. Wang believes that due to its cold nature and the special fishy smell of decoction and dry powder, the conventional dose (6 ~ 9 g) is not effective in relieving cough and asthma. If the dosage is increased, it will easily lead to gastrointestinal side effects, especially for children and elderly patients with poor spleen and stomach function, which is even more unacceptable. Therefore, Mr. Wang constantly reformed the dosage form of earthworm, and successively treated chronic bronchitis and asthma with injection, compound Longxing tablets and Tommy Tam oral liquid, and achieved good results. Second, reuse paint, eliminate phlegm and eliminate drinking.
Zeqi was first seen in Shennong's Classic of Materia Medica, "The main skin is hot, the ascites is heavy, the limbs are swollen, and the husband's yin is insufficient." Compendium of Materia Medica records that "lacquer tastes bitter, slightly cold and nontoxic". "Synopsis of the Golden Chamber" used Zeqi Decoction to treat cough caused by excessive phlegm and heavy pulse. In many years of clinical practice, Mr. Wang found that it is a cough-relieving and expectorant drug with definite curative effect. Crystal ⅰ and crystal ⅱ of Euphorbia helioscopia extract are monomers for relieving cough and eliminating phlegm in Euphorbia helioscopia. Zeqi extract and Ze -6 powder can reduce acidic mucopolysaccharide fibers, exfoliated epithelial cells and necrotic epithelial cells in sputum, suggesting its expectorant effect. Crystal D has obvious expectorant effect, and powder D has good expectorant effect in pharmacology, but it has great diarrhea side effects. In the observation, it was found that other extracts except D powder were prone to dry mouth reaction after taking, which was mild, especially D crystal, and had the effect of warming and resolving phlegm. Diarrhea occurred in the whole group of powder D, but there was no dry mouth reaction, which indicated that it was cold and had the effect of heavy diarrhea and expelling drinking. The usual dosage of Euphorbia helioscopia is 30 ~ 60g.
After long-term observation, the decoction and extract of Euphorbia helioscopia have no purgative and diuretic effects, and no toxic reaction was found in the function tests of heart, liver, kidney and hematopoietic system before and after treatment. The main side effects of Zeqi are stomach discomfort, dry mouth and dizziness, with an incidence of 6.08%. Therefore, people with stomachache, old age and weak spleen and stomach should use it with caution or in small doses. There have been reports of upper gastrointestinal bleeding caused by improper medication.
Three. Ephedra and ephedra root-declaration and merger.
Ephedra is an important drug for treating lung diseases, which has the function of relieving exterior syndrome and relieving asthma. The following questions should be paid attention to when using: 1) dosage: Ephedra should be used, tailored to different people. Attention should be paid to the dosage of urban people, the physically weak, the elderly and children. Especially in the treatment of chronic bronchitis, because the patients are older, they are often accompanied by cardiovascular diseases, hypertension, or have a history of prostatic hypertrophy, and the dose should not be large, generally 3-6g. Taking a large amount of ephedra is easy to consume lung qi, and there are symptoms such as increased heart rate, elevated blood pressure, insomnia, unfavorable urination, frequent urination and so on. Therefore, before use, ask the medical history; For long-term users, the dose should not be greater than 5g. 2) drug selection; Sweating, dispelling cold and relieving exterior syndrome can be used with raw ephedra, which has strong pungent dispersing effect; Dispelling lung and relieving asthma, and mixing with roasted Herba Ephedrae. 3) Ephedra combined with Radix Paeoniae Alba or Radix Glycyrrhizae can reduce its side effects. Ephedra root, the ancients thought it was dedicated to antiperspirant. In 1970s, it was reported that ephedra could relieve cough, phlegm and asthma. According to Mr. Wang's experience, the use of ephedra and ephedra root can not only relieve asthma and spread lung, but also supervise each other, such as ephedra sweating, ephedra root sweating, ephedra increasing blood pressure and ephedra root lowering blood pressure. For patients with cough and asthma accompanied by excessive sweating, these two drugs are often used together. Those who can't tolerate ephedra can be replaced by ephedra root.
4. Cicada and Bombyx Batryticatus-Qufeng Allergy
Cicada, sweet and cold, enters lung and liver meridians. It has the effects of dispelling pathogenic wind, clearing away heat, relieving sore throat, relieving convulsion and stopping epilepsy. Pharmacological experiments show that it has sedative effect, can reduce the tension of striated muscle, can also reduce reflex reaction, and has the blocking effect of ganglion. Bombyx batryticatus, salty, pungent and flat, enters the lungs and lung meridians. He is good at calming wind and relieving spasm, dispelling wind and clearing heat, resolving phlegm and resolving stagnation. Pharmacological analysis: protein contained in Bombyx Batryticatus can stimulate adrenal cortex and kill bacteria. Mr. Wang often uses two drugs to treat lung diseases. He believes that the two drugs can not only clear lung qi, dispel wind and dissipate heat, but also calm and relieve spasm, and also have anti-allergic and anti-virus effects. Dispelling wind, resolving phlegm and relieving sore throat can be combined with Fructus Arctii, Radix Platycodi and Radix Glycyrrhizae; Clearing heat and relieving cough can be combined with Fructus Forsythiae, Bupleuri Radix and Scutellariae Radix; Cough for a long time is accompanied by itchy throat because of wind evil and love for the lungs. For Su Xuan, it can be combined with Tianzhu Zi and Chimonanthus praecox. Clearing heat and relieving asthma can be compatible with Belamcanda and Ephedra; It can dispel wind, cool blood, promote diuresis and relieve itching. It can be used with Cortex Moutan, Cortex Dictamni Radicis and Kochia scoparia. It can clear away heat, improve eyesight and relieve headache. It can be used with mulberry leaves and Vitex negundo.
Five, scorpions and centipedes-Tongluo Pingchuan
Scorpion, an important medicine for treating wind, has the functions of calming wind, relieving spasm, expelling wind and relieving pain, detoxicating and resolving hard mass; Scolopendra is good at searching wind, dredging collaterals, relieving spasm, detoxifying and relieving pain. Clinically, it is often used to treat acute and chronic convulsions, tetanus, rheumatalgia, headache and sores. Mr. Wang often uses two drugs to treat acute asthma attacks. He believes that the characteristics of asthma attack are sudden, paroxysmal and repetitive, which is similar to the characteristics of wind "good behavior and rapid change", so adding two drugs in treatment can often get good results. Teacher Wang thinks that the drugs for expelling wind and relieving spasm have the functions of antiallergic and relieving bronchial contracture, and also have a certain effect on cough.
achievements in scientific research
I. 1987 ~ 1990
"Clinical Experimental Study on Kidney Deficiency and Essence of Chronic Bronchitis and Drugs for Nourishing Kidney and Supplementing Qi" won the third prize of scientific and technological achievements of Shanghai University of Traditional Chinese Medicine.
(1) In this study, the internal relationship between the essence of kidney deficiency in chronic bronchitis and pulmonary ventilation function, gonadal function, cellular immune function and some plasma proteases was discussed.
(2) According to the principle of "treating the root cause", we used Xianling mixture for warming yang and benefiting qi and Dihuang mixture for nourishing yin and benefiting qi to treat chronic bronchitis, and observed the changes of its curative effect and laboratory compliance, and compared it with the control group which only treated the symptoms, so as to explore the curative effect of Bushen Yiqi medicine.
(3) The animal model experiment of hypoxia showed that Bushen Yiqi medicine could increase arterial oxygen partial pressure, reduce venous oxygen partial pressure, correct alkalemia, and eliminate the damage of SOD activity and oxygen free radicals caused by hypoxia, which was confirmed in histology.
(4) Based on the clinical and animal experimental data, it is preliminarily expounded that the compatibility of tonifying kidney and benefiting qi can give full play to the complementary functions of "golden water", "replenishing essence and transforming qi" and "benefiting qi and producing essence", thus improving the level of cellular immunity and sex hormones, enhancing anti-infection ability and improving ventilation function. Drugs can also improve the body's ability to resist hypoxia and fatigue, and improve the patient's spirit, body and the number of colds.
2. 1976 ~ 1978 participated in the "scanning electron microscope observation of macrophages in the cystic fluid of patients with chronic bronchitis" and won the national medical and health science conference award.
3. 1974 ~ 1978 participated in the "Research on Yin and Yang Theory of Traditional Chinese Medicine with Modern Scientific Methods" and won the first prize of the Central Ministry of Health.