Women's "Enemies in Life": Dysmenorrhea and "Ibuprofen"
As an anesthesiologist, in our common visual pain score, severe dysmenorrhea score can even reach seven to eight points of the total score, which can be said to be very serious. So how does dysmenorrhea happen? How does ibuprofen, a commonly used analgesic, produce analgesic effect?
As we all know, menstruation is 14 days after ovulation. The periodic shedding of endometrium is caused by the withdrawal of sex hormones in the body. In this process, due to the destruction of endometrial cells, prostaglandin pgf2a will be released continuously, causing strong contraction of uterine muscles. Prostaglandin here is the chief culprit of dysmenorrhea. Seeing this, some people may think that prostaglandin only exists in male compatriots, but this is not the case.
Prostaglandins can promote the continuous compression and contraction of uterus to eliminate necrotic endometrium. In this process, the blood supply and nutrition of the surrounding tissues are cut off due to the continuous blunt instrument extrusion, which will lead to ischemia and hypoxia, and acidic metabolites will accumulate in the endometrium, which will stimulate nerve endings to produce pain.
More sadly, prostaglandin itself, as an inflammatory factor, often cascades and enhances the inflammatory response, and it will continuously release analgesic factors, resulting in more sensitive pain!
At the same time, a large amount of prostaglandin will also accumulate in the lower limbs, abdomen and back, which is also the reason why dysmenorrhea sometimes leads to low back and leg pain.
In addition, prostaglandins may cause many unpleasant experiences to the human body, so I won't go into details here.
Ok, how to relieve dysmenorrhea? Many girls will mention a "magic", namely ibuprofen.
Women's "Enemies in Life": Dysmenorrhea and the Magic Drug "Ibuprofen"
Ibuprofen itself is a drug that inhibits the release of prostaglandin. About this medicine, we will analyze it one by one:
0 1.
First of all, ibuprofen belongs to NSAID category and belongs to non-steroidal antipyretic, analgesic and anti-inflammatory drugs. Reduce prostaglandin secretion by inhibiting cyclooxygenase. It is not a central analgesic, so it is not a central analgesic. It's addictive.
02.
Secondly, ibuprofen is a super drug, which means it can be bought in any drugstore, but you need to pay attention when using it. Ibuprofen is metabolized by the liver and excreted by the kidney. Therefore, patients with hepatic and renal insufficiency should use it with caution.
03.
Third, ibuprofen is irritating to the gastrointestinal tract. Excessive use can lead to side effects such as nausea, vomiting or stomachache. Therefore, the recommended dose for adults is 400 ~ 600mg twice a day with an interval of 6 ~ 8 hours. Use. Ibuprofen needs to be taken in advance and usually takes effect within half an hour. The combination of ibuprofen with other analgesics, anti-inflammatory drugs or antibiotics is not recommended. 04
Fourth, people with the following contraindications should not take ibuprofen: serious gastrointestinal diseases allergic to drugs, such as ulcer bleeding and perforation, pregnancy and lactation.
To sum up, ibuprofen has the characteristics of small side effects, no addiction and quick onset. It is the first-line drug to relieve dysmenorrhea at present.
In addition, I repeat, because ibuprofen is not a central analgesic, there will be no problem of analgesic abuse. Female friends can take it boldly, but it needs to be emphasized that if dysmenorrhea is very serious, painkillers are difficult to relieve. Be sure to go to the hospital to rule out the possibility of secondary dysmenorrhea or severe endometriosis (this disease will be discussed separately later).
In addition, for some female friends, low-dose estrogen and progesterone perfusion therapy combined with short-acting contraceptives is also an effective way to relieve dysmenorrhea. You can consult a gynecologist for details.
Perhaps we have never heard of the word dysmenorrhea, but not everyone knows or understands dysmenorrhea, which even makes women with dysmenorrhea "self-righteous" pretentious and even sings without illness.
At the same time, there is no so-called western women's health, western women have no dysmenorrhea, and our sisters are very fragile. In the face of dysmenorrhea, women all over the world are suffering. European and American women keep making noises, and their slogan is: Dysmenorrhea is abnormal. More and more women and medical experts in the world are also aware of this concept.
Therefore, we need to speak out, arouse more sympathy and impart more knowledge to relieve dysmenorrhea. For men, don't underestimate dysmenorrhea. It may be the "devil" who tortures your girlfriend all her life; For women, don't be afraid of dysmenorrhea. Modern medicine can relieve pain to the greatest extent. Please don't be shy to see a doctor.