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How can long-term use of metformin with glimepiride minimize harm?

It is believed that most of the sugar lovers are familiar with metformin, which is recognized as the first-line drug for the treatment of type 2 diabetes. In recent years, studies have found that metformin not only has a significant role in lowering blood sugar and weight loss, but also has many roles in other aspects, such as metformin has an anti-aging effect, prevention of smog-induced inflammation, cardiovascular protection, improvement of polycystic ovary syndrome, improvement of intestinal flora, reversal of pulmonary fibrosis, anti-inflammatory, inhibition of tumor growth, reversal of biological age and so on

Metformin has been clinically applied for 60 years, and domestic application for more than 30 years. Due to its superior effectiveness and safety, it is favored by sugar lovers. Metformin, as a core drug for diabetes control, is widely used in clinical practice. If there is no contraindication or intolerance, metformin is the first choice for the treatment of type 2 diabetes. However, a very common phenomenon that many people encounter when using metformin is abdominal pain and diarrhea!

Diarrhea caused by taking metformin is a sign of intolerance and a major side effect of metformin, most often occurring after 10 weeks of medication. Common adverse reactions to metformin include diarrhea, bloating, nausea, vomiting, dyspepsia, malaise, abdominal pain, and headache. , and this symptom occurs in most patients, and this is no exception.

There have been many studies on the risk of lactic acidosis from metformin. Lactic acidosis is a state in which lactic acid accumulates in the body and can be fatal. In fact, the risk of metformin-induced lactic acidosis is very rare. "Considering the widespread use of metformin, the number of reports in the literature of lactic acidosis associated with metformin is small." Metformin has been used safely in contraindicated patients and can be considered evidence that it does not cause lactic acidosis." The report goes on to explain that like most medications, taking large amounts of metformin can lead to fatal lactic acidosis . "Lactic acidosis from metformin overdose, especially in young adults without risk factors, suggests that metformin can cause lactic acidosis if taken in large amounts."