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Pharmacology and Toxicology of Ambroxin Hydrochloride Injection

1. Pharmacological effects

This product is the metabolite of bromhexine in the body, which has the characteristics of mucous phlegm excretion and promotion of dissolution of secretion, and it can promote the elimination of mucous secretion in the respiratory tract and reduce the retention of mucus, which significantly promotes the excretion of phlegm and improves respiratory status. When this product is applied, the patient's mucous secretion can be restored to the normal condition, and the cough and sputum amount are usually significantly reduced, and the surface-active substances on the mucous membranes in the respiratory tract can perform their normal protective functions. The surface-active substances on the mucous membrane can thus fulfill their normal protective function.

2. Toxicological effects

The toxicity index of Ambroxol Hydrochloride is very low in acute toxicity test, and Ames test and micronucleus test show that Ambroxol Hydrochloride is not mutagenic. Carcinogenicity studies in mice and rats showed that Ambroxol Hydrochloride is not carcinogenic.