This article directory at a glance: 1, chitosan what are the traits and characteristics of chitosan 2, to understand the chitosan please enter 3, what is chitosan, what are the effects 4, chitosan efficacy of chitosan 5, chitosan potassium xanthate efficacy of chitosan what are the traits and characteristics of chitosan? Common name Chitosan, ChitosanOther names Chitin, Chitosan, Chitosan, Chitosan, Chitosan, StirlingChemical name (1,4)2Acetylamino 2 Deoxy βD Glucan [(1,4)2Acetylamino 2 Deoxy βD Glucose]Molecular formula (C6H11NO4)nMolecular weight (161.1)nChemical structure nHOHOOHNH2OOOHNH2OOHNH2OOHOOHNHOHO
Schedule
Physical and Chemical PropertiesThe pure product is white or off-white amorphous flake or powder, odorless, tasteless, soluble in dilute acid, organic acid.
Chemical properties are stable, high temperature resistant, unchanged after high temperature sterilization.
Soluble in dilute acids such as salicylic acid, tartaric acid, lactic acid, succinic acid, glycolic acid, malic acid, ascorbic acid.
Dissolved in dilute solution of weak acid chitosan processed into the film, with air permeability, moisture permeability, penetration, extension and anti-static effect.
In hydrochloric acid aqueous solution heated to 100 ° C, can be completely hydrolyzed into glucosamine hydrochloride.
Chitosan can deacetylate into chitosan in strong alkaline aqueous solution.
In alkaline solution or ethanol, isopropanol can be with ethylene oxide, chloroethanol, propylene oxide to generate hydroxyethylated or hydroxypropylated derivatives, soluble in water.
Produces salts with formic acid, acetic acid, oxalic acid, lactic acid and other organic acids.
Toxicity Acute oral LD50 in rats >15 g/kg.
Physiological effects and efficacy of antibacterial and bacteriostatic effects, fertilizers made with chitosan are conducive to the inhibition of the growth of germs and bacteria in the soil; enhance plant resistance and promote plant growth.
Promoting the formation of plant healing tissue, and the absorption of nitrogen, potassium and other nutrients.
Methanamine is not a fungicide, but it can activate the activity of plant enzymes and induce the plant system to acquire disease resistance, thus reducing the use of pesticides and environmental pollution.
Schedule (cont'd)-1
1.Mode of use
Dipping, spraying, watering.
2.Applicable Crops
Commonly used as a component of seed coating agent, can also be used to improve the soil, as a pesticide slow-release agent, fruit preservation agent.
Knowing the chitosan, please enter the chitosan's efficacy and role in regulating various human diseases.
Chitosan, also known as chitosan.
Medical name "chitosan", exists in the nature of crustaceans epidermis, marine organisms shrimp and crab foot shells, as well as fungal substances such as fungus ear mushrooms in the cell wall.
Chitosan is a kind of food fiber, so it has the versatility and function of food fiber, which can absorb water, increase stool volume, promote gastrointestinal peristalsis, effectively inhibit the gastrointestinal tract harmful bacteria and promote the growth of beneficial bacteria.
So it can not only laxative to solve stubborn constipation and gastrointestinal diseases have good therapeutic effect, and effectively prevent the occurrence of colorectal cancer.
Because of the specificity of the chemical structure of chitosan, it is different from the general plant cellulose, which can be digested and absorbed by the human body after being decomposed by lysozyme in the human body, thus playing a full range of physiological functions of the human body's role as a regulator.
Such as the activation of human cells, anti-aging; activation of human immune function, prevention and treatment of disease; regulation of human physiological functions, to maintain the balance of the human body's life rules; prevention and treatment of diseases; and to promote the healing of diseases, rehabilitation.
Specifically, it can be summarized as follows: one supplement, three adjustments, three rows, three lowering, three inhibitory effects.
1. A complement: supplementing the human body needs the universe's only cationic animal cellulose with a positively charged nucleus.
2. Three regulation: immune regulation; PH value regulation; endocrine regulation.
3, three rows: the exclusion of harmful cholesterol; exclusion of heavy metals; the human body endotoxin.
4, three lowering: lowering blood lipids, lowering blood sugar, lowering blood pressure
5, three inhibition: inhibit cancer cells to prevent cancer recurrence; inhibit cancer metastasis; inhibit cancer virus.
"Chitosan" is a functional health food, but it has excellent therapeutic effects on difficult modern diseases, and it is the only product authorized by the Japanese government to publicize its therapeutic effects.
Because it does not target a particular disease, but strongly regulates the physiological activities of the entire body, keeps them in an optimal state, and improves the body's ability to overcome disease by itself - the natural healing power - so that it can overcome disease.
A large number of scientific experiments and clinical applications have proved that chitosan has obvious curative effects on the following diseases:
1. Adult diseases of modern civilization: such as hypertension, arteriosclerosis, coronary heart disease, and other cardiovascular and cerebrovascular diseases.
And has a good effect on the recovery of hypertension, cerebral hemorrhage, atherosclerosis, cerebral thrombosis, cerebral infarction and other sequelae.
2, chronic diseases: where the duration of more than half a year, repeated clinical treatment has no significant effect of chronic diseases, such as chronic bronchitis, tuberculosis and other chronic diseases in the enhancement of their ability to fight disease will receive good results.
3, allergic diseases, allergic diseases: abnormalities in immune function is the root cause of these diseases.
Such as rheumatism, rheumatoid, acute and chronic glomerulonephritis, lupus erythematosus.
The stubborn skin disease psoriasis, etc. can be improved and treated due to the regulation of immune function by the gibberellic acid.
4, liver disease: chitosan can effectively activate liver cells, activate the liver microcirculation, enhance the detoxification of liver cells, detoxification function, and favorably promote the recovery of damaged liver cells, a variety of liver diseases, hepatitis, fatty liver, cirrhosis and so on, has a significant effect.
5, neuroendocrine diseases: chitosan effectively regulates neuroendocrine function, activates cells, activates endocrine glands, on Alzheimer's disease, epilepsy, cerebral atrophy and other neurological diseases and endocrine diseases such as diabetes, menopausal syndrome, etc. are effective.
6, digestive disorders: as animal cellulose chitosan to improve gastrointestinal function, dissolved in gastric acid in the stomach to form a jelly-like protective film on gastric ulcers, gastritis, enteritis can play a multiplier effect.
7, the treatment of burns, scalds, trauma, accelerate healing: chitosan not only prevents bleeding in the affected area, blood seepage, reduce the pain of wounds, but also activate the cells, produce a large number of collagen fibers quickly form a detailed skin, correct and timely use of the scar can not be left.
At the same time, has a very good activation of skin cells, anti-ultraviolet and other skin care and beauty effects.
8, a variety of cancer: kill cancer cells, cancer and prevent recurrence.
Inhibit the growth of capillaries in tumor; reduce the nutritional supply of tumor; reduce the spread of tumor to the surrounding; blockade the cancer cells so that they can't connect with vascular endothelial adhesion factor; inhibit the metastasis; inhibit the cancer virus, improve the appetite, and alleviate the pain of patients.
What is chitin, what is the effect of chitin is a combination of chitin and chitosan (chitosan).
1, antibacterial effect - chitin, chitosan can inhibit the proliferation of bacteria such as staphylococcus and Pseudomonas aeruginosa, as well as molds such as Fusarium (Escherichiacoli, Staphylococcusaureus. BacillussubtilisSalmonellatyphimurium, Candidaalbicans) reproduction.
Chitosan fiber and cotton blended knitted fabric by a medical school immunology teaching and research department tested its inhibition rate of golden grapes, Escherichia coli, Candida albicans are high 99% or more.
Anti-bacterial deodorant effect is remarkable.
2, immunity strengthening effect - chitin, chitosan can make the immunity to play a leading role in the activation of large food cells, improve immunity.
3, cell activation effect - to promote the secretion of LYSOZYME, help wound healing.
4, adsorption of chloride ions role - adsorption of chloride ions, which is the main factor leading to hypertension pathology, to prevent and control hypertension, and play a preventive effect.
5, cholesterol-lowering effect - inhibit the production of cholesterol, remove excess fat content.
6, hemostatic effect - with can make play a hemostatic effect of platelets start clotting effect.
7, coagulation effect - adsorption, removal of radioactive energy substances and heavy metals.
8, Xu release effect - protection and gradual release of efficacy.
9, Increase effective bacteria-Increase the reproduction of effective bacteria such as bifidobacteria.
10, Anti-cancer-strengthen the lymphocytes that can destroy cancer cells and prevent the metastasis of cancer cells.
11, biodegradation effect-decomposition of plants, animals and microorganisms.
Effects of chitosan Chitosan is a polysaccharide composed of aminoglucosan and acetylaminoglucosan polymers, which can be obtained by partial deacetylation of chitin in the shell.
It also occurs naturally in certain microorganisms and yeasts.
The term chitosan refers to a series of chitosan polymers with different molecular weights (50 kDa to 2000 kDa), viscosities and degrees of deacetylation (40% to 98%).
Chitosamine is insoluble in neutral and alkaline solutions, but forms salts with inorganic and organic acids such as glutamic acid, hydrochloric acid, lactic acid and acetic acid.
The amino group of the polymer is protonated, producing a soluble polysaccharide with a positive charge.
The most commonly used chitosan salts are glutamate and hydrochloride.
Efficacy
Tablets
Chitosan has extremely good properties as an excipient for direct compression of powders.
The addition of chitosan to commonly used excipients (mannitol, lactose or starch) improves the flowability of the powder mixture by lowering the angle of repose.
The results of dissolution tests of chitosan mixed with lactose and cardiac glycosides hydrochloride in direct tabletting showed zero release.
Chitosan, if added to tablets at concentrations higher than 5%, was superior to corn starch and microcrystalline cellulose as a disintegrating agent.
The disintegration effect of chitosan depends on the degree of crystallinity, degree of deacetylation, molecular weight and particle size.
Upadrashta et al. found that chitosan is also an excellent binder for tablets, and compared with other excipients, the order of adhesion was as follows: hydroxypropylmethylcellulose; chitosan; methylcellulose; sodium carboxymethylcellulose.
Another advantage of chitosan is its potential use in the administration of ulcer-prone drugs such as aspirin.
In fact, the gel-forming properties of the polysaccharide at low pH, as well as its antacid and anti-ulcer properties, allow this polymer to prevent gastric irritation by certain active compounds.
Kawashima et al. prepared aspirin tablets containing chitosan, and the presence of chitosan resulted in a slow release of aspirin, reducing gastric irritation, the most common side effect of aspirin.
Acikgoz et al. found that chitosan attenuated the irritation of another anti-inflammatory drug, diclofenac sodium, on the gastric mucosa.
Controlled-release dosage forms
The potential use of chitosan in the pharmaceutical industry for the development of controlled-release drug delivery systems has been widely explored.
This is due to its unique polymeric cationic properties, gelling and film-forming properties.
These delivery systems should be capable of controlling the rate of drug delivery, prolonging the duration of effective therapeutic action, and also potentially targeting the drug to a specific site.
A large number of drug delivery systems have been reported in the literature, including particulate systems, controlled release skeletons, soluble skeletons, and controlled release gel systems.
Combining chitosan and chitosan derivatives with other excipients to prepare tablets with controlled-release properties has revealed that the rate of drug release is, to some extent, directly related to the amount and type of chitosan used, and that zero-stage release models can be obtained.
Most gel-forming polymers form gels at high pH, so it is clear that chitosan can be used for enteric controlled release.
Theophylline controlled-release tablets were prepared using a hydrated colloidal backbone system of chitosan, Carbomer?934P, and citric acid, and it was found that a non-soluble backbone could be formed when the amount of chitosan exceeded 50% of the weight of the tablets, whereas a rapid-release backbone could be formed when the amount was less than 33%.
The amount of chitosan is less than 10% and can be used as a disintegrant.
The addition of sodium alginate in the preparation of tablets gives the tablets a wider range of release characteristics.
Citric acid gels chitosan and therefore affects the controlled release properties, and Carbomer degrades the disintegration properties of chitosan.
Akbuga studied the relationship between the release characteristics of chitosan maleate skeletal tablets and the physicochemical properties of the drug and found that drug solubility, dissociation and molecular weight were important influencing factors.
Gel
Miyazaki et al. explored the use of chitosan dry gel as a sustained-release backbone for difficult-to-solve drugs such as indomethacin and opium poppy hydrochloride.
Drugs dispersed in the gel showed zero-grade release, with 40% release of indomethacin in pH 7.4 buffer for 24h and 100% release of popaverine hydrochloride in 0.1NHCl for 24h.
These results were confirmed by the results of the release studies of lidocaine (and its salts) from methenamine hydrated colloids and gels by Kristl et al.
Deacetylation and chitosan content are important factors affecting release.
The modeling of release from gels is consistent with zero-level kinetics.
Knapczyk prepared gels with 93% and 66% deacetylated chitosan and lactic acid and found that gels prepared from high deacetylated chitosan were more stable in binding to the drug than gels prepared from low deacetylated chitosan.
Promoting dissolution
Dissolution of insoluble drugs is an important factor affecting drug absorption.
Methanamine has been found to increase the dissolution properties of insoluble drugs, such as ashwagandha or prednisolone, when ground with them.
For acidic drugs with low solubility, such as indomethacin, the positively charged aminoglycan group of chitosan interacts with the negatively charged drug to form a gel, increasing solubility and controlling release.
Hou et al. showed that particles made of chitosan and indomethacin released the drug faster at pH 7.5 than particles made of acidic gastric juice at a lower pH than particles made of indomethacin.
This was due to the swelling of chitosan to form a gel at low pH.
In comparison, if the particles are cross-linked with glutaraldehyde, swelling and gel formation are reduced and at intestinal pH brown achieves a slow release.
Bioadhesion
Takayama et al. prepared oral tablets with chitosan and sodium hyaluronate to study their bioadhesion as well as the rate of release of model drugs.
The tablets prepared with only chitosan were found to have poorer mucosal adhesion than those prepared with sodium hyaluronate alone or with both polymers.
The rate of drug release was highly dependent on the weight ratio of chitosan in the tablets; a constant release rate was obtained with chitosan ratios between 10% and 60%, with a rapid increase at higher ratios.
Miyazaki et al. performed in vivo and in vitro assays on oral mucoadhesive tablets prepared with chitosan and sodium alginate.
Increased in vitro bioadhesion with increasing alginate content illustrated the strong bioadhesive properties of alginate.
In vivo tests showed that, on the one hand, the tablets adhered tightly to the mucous membranes in the sublingual area and, on the other hand, significantly improved the bioavailability of the drug for sublingual administration.
In addition, the bioadhesion system is easily accepted by patients as it is neither irritating nor unpleasant taste or discomfort.
Colonic administration
More recently, methomyl, in capsule form, has been used for the specific colonic administration of insulin.
Methionine capsules are coated with an enteric coating (hydroxypropylmethylcellulose phthalate) and contain various absorption enhancers and enzyme inhibitors in addition to insulin.
The capsules were found to disintegrate in the colonic region, suggesting that disintegration is either due to the low pH at the ascending colon (as opposed to the terminal ileum) or to the presence of microbial enzymes capable of degrading chitosan.
Microspheres and microcapsules
Microspheres of chitosan for implantation or oral controlled-release drug delivery systems have been extensively studied.
Generally, such microspheres are prepared by an emulsification cross-linking process or by coordination between oppositely charged macromolecules.
Nishioka et al. prepared glutaraldehyde-crosslinked chitosan microspheres containing cisplatin.
The encapsulation rate of the drug increased significantly with the increase of chitosan and chitosan content, and the slow release effect was enhanced with the increase of chitosan content from 1% to 5% and chitosan content from 0% to 1.5%.
Similar microspheres containing mitoxantrone were prepared by Jameela et al.
The degree of drug release could be effectively controlled with the degree of cross-linking, and only about 25% of the drug was released from the microspheres at high cross-linking degree for 36 days.
The microspheres were not biodegradable in rat muscle.
Akbuga et al. prepared tachyzoite microspheres using a W/O emulsification system.
The properties of the microspheres were influenced by preparation factors such as concentration and type of chitosan, drug concentration and cross-linking process.
The peptide salmon calcitonin was encapsulated with tritiated phosphonic acid cross-linked microspheres and released slowly over 27 days.
Mi et al. prepared microspheres containing hygromycin by both interfacial acetylation and spray-hardening with chitosan microspheres with molecular weights of 70 kDa, 700 kDa, and 2000 kDa, respectively.
The experimental results showed that the higher the molecular weight of chitosan, the greater the slow release of the drug.
Aideh et al. prepared similar microspheres of chitosan encapsulating insulin with ascorbyl palmitate cross-linked on the surface of the microspheres.
The rate of drug release was determined by the amount of chitosan in the microspheres, which allowed sustained drug release for up to 80 hours.
Recently, cross-linking with polyanionic sodium tripolyphosphate and polyethylene oxide? poly(propylene oxide***) polymer crosslinked chitosan microspheres have been proposed for use as carriers for oral administration of proteins and vaccines.
Release of the antigen is slow, with only 20% of the tetanus toxoid released over 18 days.
Chitosan microspheres can also be prepared by the emulsification-one-ion-gel method, which insolubilizes chitosan by raising the pH of the emulsion system.
Polyelectrolytes of opposite charge act rapidly in solution, usually forming insoluble precipitates.
This principle is used in the preparation of chitosan microspheres, thus avoiding the use of cross-linking agents.
Polk et al. reacted chitosan with sodium alginate in the presence of calcium chloride to produce microcapsules with polyelectrolyte complex membranes.
The rate of albumin release from the microcapsules was dependent on the concentration of alginate and the molecular weight of the chitosan, with the rate of albumin release decreasing with an increase in these two factors.
Remunan?Lopez et al. prepared chitosan gel cohesive layer microspheres using the same principle.
Recently, Liu et al. prepared porous microspheres by gelling chitosan with sodium alginate and then freeze-drying.
Interleukin?2 diffused from an external aqueous solution of the drug to bind to the preformed microspheres.
The drug was found to be released from the microspheres in a slow-release manner.
Because of the slow release of the cytokinin, the drug stimulated the inhalation of cytotoxic T lymphocytes (CTLs) more efficiently than the free drug.
Wound Healing Agents
The scientific basis for the wound healing-promoting effectiveness of methenamine was first reported in 1978.
The chitosan acetate film that contacts and protects the wound has the advantages of good oxygen permeability, strong water absorption, and slow enzymatic (lysozyme) degradation, thus obviating the need for repeated applications.
Treatment of various dog tissues with chitosan solutions leads to inhibition of fibrous tissue formation and promotes tissue regeneration.
Significant progress has been made in the development of wound healing agents for veterinary use, with SunfiveInc of Japan opening the development and marketing of a chitosan cotton (ChitopakTMC) and a chitosan suspension (ChitofineTMS).
3M has marketed a human wound healing agent (TegasorbTM?) containing chitosan as an excipient.
Promoting absorption
Illum et al. first proposed that chitosan could perform transmucosal absorption of polar small molecules and peptide and protein drugs.
In a sheep model, they found that the addition of chitosan to a nasal insulin prescription caused a decrease in plasma glucose levels to 43% of the original level, compared with only 83% of the original level for the unadded chitosan prescription.
At the same time, plasma insulin levels increased from 34 mIU/1 to 191 mIU/l, a sevenfold increase in AUC.
Similar results were obtained for other small molecular weight drugs, such as morphine and anti-migraine drugs that are polarized in nature, as well as peptides such as calcitonin, desmopressin, goserelin, parathyroid-releasing hormone, and leuprolide.
Results from studies in human volunteers confirm the results of the sheep trial.
Chitosan can be applied in the form of a simple solution (concentration 0.5-1.0%), or chitosan microspheres can be prepared by spray drying.
This powder prescription is more effective in facilitating drug transport across cell membranes compared to chitosan solutions.
Bioavailability of chitosan powder and microspheres reached 20-40% for peptides (goserelin, leuprolide, and parathyroid hormone) in sheep model tests.
The results of clinical trials also confirmed the animal test results.
Consistent with nasal absorption studies, Rentel et al. reported that chitosan also promotes transmucosal absorption of the peptide 9?deglycosaminide?8?arginine pressin solution administered in rat enterospheres.
Subsequent experimental results have shown that the effect of chitosan on mannitol penetration into Caco2 cells depends on the degree of deacetylation and the molecular weight of chitosan.
Recently, chitosan solutions have also been reported to increase buserelin 50% intestinal absorption.
Derivatives of chitosan have similar absorption-promoting effects.
N?trimethyl chloride chitosan is more water-soluble and therefore easier to prepare in solid oral dosage forms than chitosan itself.
The less successful studies of solid dosage forms containing chitosan are due to the slow dissolution of chitosan in powder form.
Rat and pig modeling studies of peptides such as insulin and calcitonin have yielded similar results.
Efficacy of potassium chitosan xanthateThe efficacy and effectiveness of chitosan in regulating various human diseases.
Chitosamine, also known as chitin.
Medical name "chitosan", exists in the nature of crustaceans epidermis, marine organisms shrimp and crab foot shells, as well as fungal substances such as fungus ear mushrooms in the cell wall.
Chitosan is a kind of food fiber, so it has the versatility and function of food fiber, which can absorb water, increase stool volume, promote gastrointestinal peristalsis, effectively inhibit the gastrointestinal tract harmful bacteria and promote the growth of beneficial bacteria.
So it can not only laxative to solve stubborn constipation and gastrointestinal diseases have good therapeutic effect, and effectively prevent the occurrence of colorectal cancer.
Because of the specificity of the chemical structure of chitosan, it is different from the general plant cellulose, which can be digested and absorbed by the human body after being decomposed by lysozyme in the human body, thus playing a full range of physiological functions of the human body's role as a regulator.
Such as the activation of human cells, anti-aging; activation of human immune function, prevention and treatment of disease; regulation of human physiological functions, to maintain the balance of the human body's life rules; prevention and treatment of diseases; and to promote the healing of diseases, rehabilitation.
Specifically, it can be summarized as follows: one supplement, three adjustments, three rows, three lowering, three inhibitory effects.
1. A complement: supplementing the human body needs the universe's only positively charged nucleus with cationic animal cellulose.
2. Three regulation: immune regulation; PH value regulation; endocrine regulation.
3, three rows: exclude harmful cholesterol; exclude heavy metals; human body endotoxin.
4, three lowering: lowering blood lipids, lowering blood sugar, lowering blood pressure
5, three inhibition: inhibit cancer cells to prevent cancer recurrence; inhibit cancer metastasis; inhibit cancer virus.
"Chitosan" is a functional health food, but it has excellent therapeutic effects on difficult modern diseases, and it is the only product authorized by the Japanese government to publicize its therapeutic effects.
Because it does not target a particular disease, but strongly regulates the physiological activities of the entire body, keeps the physiological activities in an optimal state, and improves the body's ability to overcome the disease by itself - the natural healing power - so that it can overcome the disease.
A large number of scientific experiments and clinical applications have proved that chitosan has obvious curative effects on the following diseases:
1. Adult diseases of modern civilization: such as hypertension, arteriosclerosis, coronary heart disease, and other cardiovascular and cerebrovascular diseases.
And has a good effect on the recovery of hypertension, cerebral hemorrhage, atherosclerosis, cerebral thrombosis, cerebral infarction and other sequelae.
2, chronic diseases: where the duration of more than half a year, repeated clinical treatment has no significant effect of chronic diseases, such as chronic bronchitis, tuberculosis and other chronic diseases in the enhancement of their ability to fight disease will receive good results.
3, allergic diseases, allergic diseases: abnormalities in immune function is the root cause of these diseases.
Such as rheumatism, rheumatoid, acute and chronic glomerulonephritis, lupus erythematosus.
The stubborn skin disease psoriasis, etc. can be improved and treated due to the regulation of immune function by the gibberellic acid.
4, liver disease: chitosan can effectively activate liver cells, activate the liver microcirculation, enhance the detoxification of liver cells, detoxification function, and favorably promote the recovery of damaged liver cells, a variety of liver diseases, hepatitis, fatty liver, cirrhosis and so on, has a significant effect.
5, neuroendocrine diseases: chitosan effectively regulates neuroendocrine function, activates cells, activates endocrine glands, on Alzheimer's disease, epilepsy, cerebral atrophy and other neurological diseases and endocrine diseases such as diabetes, menopausal syndrome, etc. are effective.
6, digestive disorders: as animal cellulose chitosan to improve gastrointestinal function, dissolved in gastric acid in the stomach to form a jelly-like protective film on gastric ulcers, gastritis, enteritis can play a multiplier effect.
7, the treatment of burns, scalds, trauma, accelerate healing: chitosan not only prevents bleeding in the affected area, blood seepage, reduce the pain of wounds, but also activate the cells, produce a large number of collagen fibers quickly form a detailed skin, correct and timely use of the scar can not be left.
At the same time, has a very good activation of skin cells, anti-ultraviolet and other skin care and beauty effects.
8, a variety of cancer: kill cancer cells, cancer and prevent recurrence.
Inhibit the growth of capillaries in tumor; reduce the nutritional supply of tumor; reduce the spread of tumor to the surrounding; blockade the cancer cells so that they can't be connected with vascular endothelial adhesion factor; inhibit metastasis; inhibit the cancer virus, improve the appetite, and alleviate the pain of patients.
About the effects and role of methylamine and the effects and roles of methylcellulose is the end of the introduction, I do not know you find the information you need from it? If you still want to know more information in this regard, remember to collect the collection of this site.