Poria cocos, as a Chinese herbal medicine, has the functions of inducing diuresis to reduce swelling, strengthening the spleen and calming the heart. However, if taken for a long time, it may cause certain damage to the body, leading to adverse reactions of urinary system, digestive system and cardiovascular system. The common clinical adverse reactions are: 1, urinary system: Poria cocos has a certain diuretic and detumescence effect, which can cause frequent urination, urgency, increased urine volume and endless urination. If the patient eats too much, it may also affect the liver and kidney function; 2, digestive system: Poria cocos can reduce the secretion of gastric juice, long-term use may cause abnormal digestive function, abdominal discomfort, indigestion, patients can see diarrhea or constipation, burping, chest tightness and burning, and even cause iron deficiency anemia; 3. Cardiovascular system: Poria cocos can enhance myocardial contractility and increase heart rate. Long-term or large-scale consumption of Poria cocos may cause tachycardia, leading to palpitation, chest tightness, dizziness and other discomfort in patients.