Osteogenesis imperfecta, also known as osteogenesis imperfecta, brittle bone disease, congenital hypoplasia, porcelain doll, primary bone brittleness, periosteal dysplasia. Affected children are prone to fractures, and minor collisions can cause serious fractures. It is a rare genetic bone disease with an incidence rate of about 3 per 100,000, and the incidence is about the same for men and women.

Treatment

No specific treatment. The main thing is to prevent fractures, and the child should be strictly protected until the tendency to fracture diminishes, but then the complications of prolonged confinement to bed should be prevented. Treatment of fractures is the same as for normal people. The period of immobilization may be short as the fracture heals more rapidly. Those with severe deformity may take measures to correct the deformity and improve the weight-bearing line of gravity.

Drug therapy includes bisphosphonates, estrogen, calcitonin, vitamin D3, but the efficacy is not certain. Stem cell therapy, gene therapy methods to be further research, identification, a short period of time can not be applied to the clinic