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What are the options for insulin treatment injections for type 1 diabetes?

Type 1 diabetes treatment injection plan: Type 1 diabetes patients have absolutely insufficient insulin secretion in their bodies, so they need to use insulin instead throughout their lives. Although dosing regimens vary, they are generally based on therapeutic control goals, the patient's response to insulin therapy, and the physician's preferences.

The conventional single-dose injection regimen is a single-dose subcutaneous injection of protamine zinc insulin or protamine zinc insulin plus regular insulin before breakfast. This regimen is suitable for the honeymoon period of type 1 diabetes and the daily insulin requirement. A few patients with less than 24 units have better results, but the condition of most patients cannot be controlled to a satisfactory level.

In order to ensure the normal concentration of insulin in the body, the multiple-daily insulin injection program involves subcutaneous injection of short-acting insulin before three meals and injection of short-acting insulin or intermediate-acting insulin before going to bed. In recent years, intensive insulin treatment is often used. A regimen of injecting short-acting insulin before three meals and injecting intermediate-acting insulin before bed was adopted.

In the improved multi-dose injection regimen, short-acting insulin is still injected before each meal, long-acting insulin is injected before going to bed, and protamine zinc insulin can be injected twice a day or every night before dinner or bedtime as appropriate. 1 injection. This protocol ensures the concentration of insulin in the patient's body.

The conventional divided-dose mixed injection regimen involves subcutaneous injection of short-acting and medium-acting mixed insulin twice a day in the morning and evening before meals. Generally, short-acting insulin and intermediate-acting insulin are mixed, and the specific mixing ratio is determined based on the patient's response to treatment. Generally, short-acting insulin accounts for 20 to 50%. Premixed human insulin can also be used directly for treatment. Commonly used is 30% short-acting insulin plus 70% intermediate-acting insulin, and premixed human insulin with 50% short-acting insulin plus 50% intermediate-acting insulin is also available.

Continuous subcutaneous insulin infusion insulin pump continuously infuses trace amounts of short-acting insulin subcutaneously on the basis of simulating insulin secretion in the body, thereby maintaining a balance between the production rate of glycogen and the utilization of peripheral tissues. During meals, the insulin pump simulates meal-related insulin secretion, significantly increasing the release of short-acting insulin. This allows for variation in meal size and meal timing, while avoiding the accumulation of large amounts of insulin under the skin.

Insulin intensive treatment regimen Type I patients mostly use intensive treatment such as multiple doses of insulin injection regimen once a day. In the early stages of intensive treatment, patients must test their blood sugar before, after, and before meals every day. If necessary, they need to measure their blood sugar at night. After their blood sugar stabilizes, they still need to test their blood sugar every day before and after three meals and before going to bed. However, It is required to measure blood sugar more than 7 times a day for observation every 1 to 2 weeks. Because the incidence of hypoglycemia in intensive treatment is high, intensive treatment is mainly used for newly diagnosed adolescents with type 1 diabetes, gestational diabetes, diabetes combined with pregnancy, and those receiving insulin pump therapy.