Escherichia coli in chickens is a common disease caused by Escherichia coli.

The disease is characterized by causing lesions such as pericarditis, perihepatitis, pneumocystitis, peritonitis, oviductitis, and synovitis. According to the symptoms and lesions can be divided into a variety of disease types: E. coli septicemia, yolk peritonitis, oviductitis, total ophthalmoplegia, sarcoidosis and so on with E. coli septicemia as the most common. Sick chickens are depressed, head shrinking and eyes closed, drinking more water, feeding reduction, some diarrhea, green and white dilute feces, some dying before the appearance of tilting the head, twisting the head and other neurological symptoms, some deaths occur one after another. The mortality rate is generally 1% to 7%.

The disease is generally treated with neomycin, quinolones, or drugs that were used sparingly in the past. around 10 days of age, intramuscular injection of inactivated chicken E. coli multivalent oil emulsion vaccine.