1, different plant sources: Cucurbita moschata is the dried and mature seed of Polygonum multiflorum Thunb, while withering melon seed is the dried and mature seed of Trichosanthes kirilowii Thunb.

2, the shape is different: the melon seeds are fuller and the color is darker. The shell of withering melon seeds is hard and the epidermis is gray.

3, the medicinal value is different: Guagua seeds and withering seeds have the medicinal value of moistening lung, resolving phlegm and relaxing bowels.