English name: Cetirizine Hydrochloride

Chemical name: (±)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

CAS registry number: 83881 -52-1

Molecular formula: C21H25ClN2O3?6?12HCl

Molecular weight: 461.82

Other names: Sterling Ciclovir Senlite

Functionality: Seasonal and perennial allergic rhinitis, rhinoconjunctivitis, urticaria, allergic reactions caused by medicines, food and insect bites.

Use and dosage: adults 10mg 1 time / day. Elderly people with renal dysfunction should reduce the dosage of the drug, children 6-12 years old 10mg1 times/day or 5mg2 times/day, children 2-6 years old 5mg1 times/day.

Pharmacology and toxicology: Cetirizine is the metabolite of hydroxyzine in the human body, animal experiments have proved that cetirizine hydrochloride is a peripheral H1 receptor antagonist, which can inhibit the transmission and action of histamine, and also inhibit vasoactive peptide and P substances involved in the metamorphic reaction to reduce the movement of inflammatory cells, effectively inhibit skin metamorphic reactions. This product can significantly reduce histamine on the airway allergic reaction caused by asthma patients, reduce the allergic reaction caused by specific allergens. It has no significant anticholinergic and anti-5-hydroxytryptamine effects. In clinical studies, cetirizine was found to have dry mouth as a more common side effect than placebo. In vitro receptor binding studies have demonstrated no significant affinity for other H1 receptors. At effective doses, it does not readily cross the blood-brain barrier and does not affect the central nervous system as a side effect.

Acute toxicity: the LD50 of the product in Kunming mice was 758.1mg/kg (95% confidence limit 712.1~806.9mg/kg) when administered orally, and the LD50 of the product in tail vein injection was 131.1mg/kg (95% confidence limit 120.8~142.1mg/kg).

Long-term toxicity: 2mg/kg is a safe dose for rats. Hepatic injury and renal insufficiency have been associated with accumulation after administration of this product.

Reproductive toxicity: this product has no reproductive toxicity.

This product is not carcinogenic or mutagenic.

ADVERSE REACTIONS AND CAUTIONS: Occasionally, mild drowsiness, headache, dizziness, dry mouth, and gastrointestinal discomfort.

Dosage forms: tablets, main size 10 mg; syrup.

Is it a medicare drug: non-medicare

Is it an over-the-counter drug: yes

Other: prohibited for children under 2 years of age and nursing women. Do not overdose for driving or machine operators. Use with caution in pregnant women. Avoid combining with tranquilizers or drinking alcohol