The largest variety and quantity of Chinese medicines are botanicals. In addition to the more common roots, stems and leaves used as medicine, and the whole plant used as medicine, there are also some flowers that can be used as medicine, such as celandine. A relatively common plant whose flowers are used as medicine. So, what are the specific effects, functions and taboos of celandine in general?

1. Alias ??and synonyms

Rehmannia glutinosa, Niu Jinhua ("Plant Collection"), Rhizoma Coptidis ("Northeast Medicinal Plants"), Babujin, Diuchangcao , Shanximelon ("Economic Flora of Liaoning"), realgar grass ("Shaanxi Traditional Chinese Medicine"), Coptis chinensis ("Handbook of Commonly Used Chinese Herbal Medicines in Liaoning"), Coptidis pseudocoptidis ("Handbook of Commonly Used Chinese Herbal Medicines in Northeast China"), Xiaoyeren Blood Grass ("Handbook of Commonly Used Chinese Herbal Medicines in Northeast China") Shaanxi Chinese Herbal Medicine").

2. Pharmacological effects

1. On the nervous system: The effect of chelidonine is similar to morphine, with obvious analgesic effect, but no anesthesia or hypnotic effect; the analgesic effect can be It lasts for 4 to 18 hours; in isolated nerve and muscle specimens, it can be seen that the stimulation response time is prolonged; a dose of 0.9 mg/kg can produce complete analgesia in mice. Cryptine can inhibit the higher center of frogs and eventually cause spinal cord paralysis; it can cause convulsions in mammals. A small dose of original opiate base has an anesthetic effect on frogs, while a large dose makes the reflex disappear and exhibits a curare-like effect. Parenteral administration of 18--200 mg/kg can cause excitement or convulsions. Sanguinarine can cause transient anesthesia, which may progress to strychnine-like convulsions. The effect of beta-homocarbine is similar to that of chelidonine, which can cause mild anesthesia, followed by convulsions; it can also paralyze sensory nerve endings.

2. Anti-cancer: The pure methanol extract of this product has obvious anti-tumor effect on mouse sarcoma and mouse Ehrlich carcinoma with low toxicity. It can be administered continuously for 7 days. At total doses of 350 and 700 mg/kg, the tumor index for mouse sarcoma 180 was 0.45-0.55, and the tumor index for mouse Ehrlich carcinoma was 0.44--0.52. The water extract and 40% methanol extract of celandine have no anti-cancer activity and are highly toxic. Crude proopioid base has no obvious anti-cancer effect on mouse sarcoma 180 and mouse cancer at a total dose of 350 mg/kg (within seven days). Crude chelidonine has a weak anti-tumor effect at a total dose of 175 mg/kg (within seven days). The tumor indexes for mouse sarcoma 180 and mouse Ehrlich carcinoma are 0.7 and 0.75 respectively, but there is a larger Cytotoxic effect. There are also reports that celandine extract has no anti-tumor activity against mouse lymphoid leukemia 11210 and rat carcinosarcoma W256, but has a cytotoxic effect on Eng1es nasopharyngeal carcinoma cells in tissue culture. Chelidonine and proopioidine have anti-tumor effects on mouse sarcoma 180 and mouse Ehrlich carcinoma, but it has also been reported that chelidonine has no anti-tumor effect on rat Jensen sarcoma. Chelidonine can change the mid- and late-stage division index of transplantable hypertripioid ascites cells in mice, showing a significant blocking effect on mitosis. After 12 hours of administration at a dose of 125 mg/kg, chelidonine stopped dividing. Those in the middle stage account for 23.1%; different doses can make the late stage cleavage index exceed normal.

3. For smooth muscle: chelidonine can inhibit the spontaneous contraction of isolated frog esophagus, stomach and cat and rabbit intestinal segments, and can eliminate pilocarpine, pituitaryin, histamine and barium chloride The stimulating effect caused; and the effect of relieving bronchospasm. Intravenous injection of chelidonine into rabbits can inhibit normal and pilocarpine-enhanced intestinal motility. Chelidonine and chelidonine extract can increase small intestinal tension and reduce large intestinal tension in rats; they have antispasmodic and analgesic effects on patients with gastric diseases. The antispasmodic effect of chelidonine on isolated rabbit small intestine was half that of papaverine. Protopioid alkaloids have a stimulant effect on rat intestines. Sanguinarine can stimulate the intestinal peristalsis of cats and rabbits in vitro or in vivo, and increase the tension and contraction amplitude; it can partially relieve the spasm caused by histamine in the intestinal segments of guinea pigs. Chelidonine can inhibit the intestinal segment of guinea pigs and partially relieve the spasm caused by histamine. Chelidonine can inhibit the spontaneous contraction of the isolated pregnant uterus of guinea pigs. Chelidonium extract can excite the uterus, while chelidonine relaxes it. Suginarine can excite the pregnant uterus of cats, but has no obvious effect on the unpregnant uterus. Protopine has an inhibitory effect on guinea pig uterine smooth muscle. .

4. Antibacterial: The crude preparation of this product can inhibit Streptococcus A, catarrhalis, Neisseria type 1, Neisseria mucosae, Streptococcus pneumoniae, Haemophilus influenzae and other Gram-positive bacteria in vitro. Mycobacterium-positive bacteria; it has the effect of inhibiting Mycobacterium tuberculosis in the body. Proopioid alkaloids, sanguinarine and chelidonine 716 and 7 nanograms/ml have inhibitory effects on Trichophyton Kaufmann-Wolfe and Epidermophyton floccosum. Low concentrations of chelerythrine and sanguinarine inhibit bacteriophages and E. coli.

5. Expectorant and antitussive: 3 g/kg water decoction of this product, intraperitoneal injection, has the effect of increasing the excretion of phenol red from the bronchi of mice, and has anti-histamine bronchospasm and sedative effects. Cough effect.

6. On the cardiovascular system: chelidonine can excite, increase blood pressure, and dilate coronary arteries. 0.01-0.02 mg can excite isolated frog hearts and slow down the heartbeat. Above 0.05 mg, the heart rhythm can be reduced. Irregularity, blockage, and diastolic asystole. In experiments on cats, chelidonine slightly and permanently reduced arterial pressure without affecting breathing. Small doses of celandine extract can relax blood vessels. Pretreating blood vessels with epinephrine and then perfusing them with chelidonine will cause greater vasodilation than using Ren's solution alone. If chelidonine perfusion is used without any pretreatment, it will have no effect. Cryptine can slow down the heartbeat or stop diastole in frogs. Small doses of proopioid alkaloids can slow the heart rate and lower blood pressure. Beta-homochelidonine can cause a temporary drop in blood pressure, slow heart rate in animals, and paralyze the vasomotor center in large doses. Intravenous injection of 1-3 mg/kg of sanguinarine into anesthetized cats can cause a short-term increase in blood pressure, followed by a decrease that lasts for 1 hour.

7. Others: The water decoction of this product can enhance the phagocytic function of mouse leukocytes. Chelidonine can increase urinary excretion; retain calcium and sodium ions. Guinea pig experiments have shown that 4 to 10 mg/kg of chelidonine can prevent or delay the occurrence of anaphylactic shock. Sanguinarine can inhibit the activity of true and pseudocholinesterase; it can increase the sensitivity of isolated frog rectus abdominis and leech dorsal muscles to acetylcholine.

8. Toxicity, the 1D50 of this decoction in mice intraperitoneally injected is 9.5-1g (crude drug)/kg. The 1D50 of intravenous injection of original opiate hydrochloride in mice is 35.9 mg/kg; the M1D of subcutaneous injection of cryptopine hydrochloride in guinea pigs is 190 mg/kg. The 1D50 of intravenous injection of sanguinarine in mice was 19.4 mg/kg.

3. Processing

Collect the above-ground parts when they bloom from May to July, dry them in a ventilated place, cut them into sections, and set them aside.

4. Meridian distribution of nature and flavor

Purient, bitter, warm and toxic.

Returns into the lung, heart and kidney meridians.

5. Indications: 1. Promotes qi and relieves pain. This product is pungent and bitter, warm in nature and cold, and enters the stomach and small intestine meridian, so it can relieve gastrointestinal qi. , dispersing the cold and warming of the gastrointestinal tract, treating cold coagulation and qi stagnation in the gastrointestinal tract. For pain caused by obstruction of fu-organ qi, use this product to clear the fu-organs and dispel cold evil. It will not cause pain if it is unblocked, it will not coagulate if it is warm, and the pain will stop on its own. It is effective for gastrointestinal pain.

2. Resolve phlegm and relieve cough. The bitter taste of this medicine is mainly for descending. It enters the lung meridian and can lower the qi in the upper lung and relieve cough. The bitter taste can remove dampness and resolve phlegm and dampness. For coughs caused by exogenous infection or internal injury, in which the lungs are unable to purify and descend, the phlegm is not clear, and the lung qi rises and falls, use this product to calm down the lung qi, relieve coughs, resolve phlegm and dampness, make the lung qi fall, and stop coughing. This product is warm in nature and is most suitable for coughs with cold phlegm.

3. Diuretic and reduce swelling. This herb is pungent and bitter, which can promote diarrhea and enter the bladder meridian. The effect of taking Xin and dispersing bitterness to relieve pain is to make water come out from the urine, and the water will help the swelling to disappear.

4. Detoxify and kill insects. This product is for external use. It has a bitter taste and can dry out dampness. It has the power to fight poison with poison and has the effect of detoxifying and killing insects. Therefore, it can be used for stubborn ringworm, sores, scabies, and poisonous three-summer injuries. Wait for proof.

6. Usage and dosage

Inner eye: decoction, 1.5-6 grams. External use: Pound and apply.

7. Xuanbo compatibility

Cheng Heyi bogey

The fifth product is poisonous, so be careful.

Compatible application

1. When used with Yincheng, it can clear away heat and remove dampness, diuresis and reduce swelling.

Artemisia arborescens is bitter and cold. The bitterness can remove dampness, the coldness can clear away heat, and it is good at exuding and urinating. Therefore, it can remove jaundice caused by dampness and heat. Chelidonium is bitter and pungent and warm, and can diuresis and reduce swelling. The two are matched, and are suitable for patients with jaundice and other symptoms. Suitable for those with edema.

2. With cloves, it is mild and relieves pain. Clove is pungent and warm and pure yang, can warm the spleen and stomach, and can reduce adverse reactions. Chelidonium is pungent and warm, promotes qi, dispels cold and relieves pain. The two are used together. The warmth of clove is increased by celandine, and the pungency of celandine is increased by clove. It can warm the body, but also activates qi and relieves pain. Therefore, it can be used for pain caused by spleen and stomach deficiency and coldness, and qi stagnation. Warm and dissipate deficiency and cold, qi stagnation, and clearing up the fu organs will relieve pain.

8. Prescriptions

1. Prescription for treating jaundice ("Sichuan Traditional Chinese Medicine"): this product, dandelion, Phytolacca, stinkgrass root, capsicum wormwood, decoct in water and take.

2. Recipe for treating gastrointestinal pain ("Sichuan Traditional Chinese Medicine"): this product, cloves, cuttlefish bones, Fritillaria fritillary, Dannanxing, winter melon kernels, decoction in water and take.

3. Prescription for treating stubborn ringworm ("Liaoning Handbook of Commonly Used Chinese Herbal Medicines"): fresh celandine, alcohol. external use.

4. Treat rice field dermatitis, poisonous insect bites, and scabies prescription ("Manual of Commonly Used Chinese Herbal Medicines in Northeast China"): This product is for external use.

9. Foods to remove liver fire

1. Rock sugar and snow pear water

Snow pears are also known as fast fruit and jade milk. They are called "Natural mineral water". Pears have the functions of producing fluid and quenching thirst, relieving cough and reducing phlegm, clearing away heat and reducing fire, moistening the lungs and removing dryness. It is suitable for cough due to lung heat, dry throat and sore throat, and dry stool. Pears also have the effects of lowering blood pressure and sedating. Its rich sugar and vitamins can protect the liver and aid digestion.

2. Water chestnut juice

Water chestnut is rich in nutrients, juicy and sweet. It has been known as "Underground Sydney" and "Jiangnan Ginseng" since ancient times. It has the effects of warming the body, replenishing qi, clearing away heat and appetizing. Clinically, it can be used to relieve symptoms of fever, polydipsia, phlegm-heat cough, and sore throat. Water chestnuts are squeezed into juice, which is sweet and quenches thirst and reduces internal heat. It can also help balance endocrine.

3. Celery porridge

Winter often causes people to have increased liver fire, causing headaches and dizziness. Celery is cold and cool in nature. It can remove liver fire and relieve heat in the lungs and stomach. It is beneficial for people who are prone to "getting angry" to eat it regularly. Celery can clear away heat and detoxify, which is very beneficial for people with strong liver fire and rough skin. It also contains a lot of crude fiber, which can stimulate gastrointestinal motility. People with strong liver fire often eat celery porridge, which has certain benefits in lowering blood pressure and reducing irritability.

4. Kelp and mung bean soup

Kelp is an ideal food for resolving phlegm, reducing inflammation, detoxifying and laxative. Mung beans have the effect of clearing away heat, relieving summer heat, clearing the liver and reducing fire. The combination of mung beans and kelp makes this mung bean and kelp soup not only relieve excessive liver fire, relieve symptoms such as headache, dizziness, bitter mouth and dry mouth, but also assist in the treatment of early-stage hypertension.

5. Lotus seed and lily soup

Lily is sweet and slightly bitter. It can moisten the lungs and relieve cough, clear the heart and calm the mind. According to "Bie Lu", it can remove edema, abdominal distension, cold and heat, and general pain. It can be used to treat lung heat, dryness cough, labor cough and hemoptysis, low-grade fever, dysphoria, palpitation, and insomnia. Endocrine disorders caused by strong liver fire may try lotus seed and lily soup.

6. Imperata Imperata Gen Xueli Pig Lung Decoction

Imperata Imperata Genta has the effects of cooling blood and stopping bleeding, clearing away heat and promoting fluid production, diuresis and treating stranguria. Snow pear is sweet in taste and cold in nature. It has the effects of promoting body fluids, moistening dryness, clearing away heat and reducing phlegm. It is especially suitable for consumption in winter. Pig lung is sweet in taste and neutral in nature. It can nourish lung deficiency and relieve cough. Therefore, this soup has the effects of clearing heat, promoting fluid production, resolving phlegm and relieving cough. It is especially suitable for people with hot body, nosebleeds, cough, or endocrine disorders.