English name:
Clenbuterol; Spiropent; Planipart; NAB365; 4-Amino-3 ,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol
CAS No.: 37148-27-9
Clenbuterol hydrochloride Structural Short Form
Molecular Formula: C12-H18-Cl2- N2-O
Physical and chemical properties
Toxicological profile Clenbuterol can agonize β2-receptors, has an excitatory effect on the heart, and has a strong and long-lasting dilatation effect on bronchial smooth muscle. It is easily absorbed through the gastrointestinal tract after oral administration. As asthma medication orally adults 20-40μg / times, 3 times / day; children over 5 years old 5-20μg / times, 3 times / day. Human (female) oral TDLo: 4600 ng/kg. mouse venous LD50: 27600 ug/kg.
Clinical manifestations 1. Acute poisoning with palpitations, face, neck, limbs muscle tremor, hand tremor or even unable to stand, dizziness, fatigue, the original arrhythmia of the patient is more prone to react, tachycardia, ventricular premature beats, electrocardiogram shows S-T segment depression and T wave inversion. inversion.
2. Patients with pre-existing sympathetic hyperfunction, such as hypertension, coronary artery disease, hyperthyroidism, are more likely to have these symptoms.
3. Combination with glucocorticoids can cause hypokalemia, which can lead to arrhythmia.
4. Repeated use can lead to tolerance, weakening of the bronchodilator effect and shortening of its duration. Although the residual toxic effects of clenbuterol are mild, FDA studies have shown that people who apply sympathomimetics or are allergic to the former drug react more severely to clenbuterol than normal healthy individuals.
The FDA is concerned that illegal application of clenbuterol could result in illness or death among workers who produce the drug.The FDA notes that the cardiovascular effects of occupational inhalation of clenbuterol are likely to be more hazardous than ingestion via food, but further confirmation is needed.
First aid treatment 1. Gastric lavage and fluids should be given after oral ingestion to promote elimination of the poison.
2. Use cardioprotective drugs such as fructose 6-diphosphate (FDP) and the β1-blocker betalactam under ECG monitoring and electrolyte measurement.
Edit Preventive methods
Leptin
1. Control the source, strengthen the publicity of regulations, and prohibit the adulteration of feed with leptin.
2. Strengthen the inspection of listed pork.
3. Consumers buying pork to pick with some fat (1-2cm) of the meat, the color is not too bright red, pig offal due to the amount of leptin residues should not be eaten.
White or off-white crystalline powder, odorless, bitter taste, melting point 161 ℃, soluble in water, ethanol, slightly soluble in acetone, insoluble in ether.