For beauty seekers, the term hyaluronic acid should be familiar. Hyaluronic acid is promoted as the basic component of hydrating in countless beauty and skin care advertisements. In fact, hyaluronic acid, also known as hyaluronic acid, was first used in the field of consumer medicine, and then used by beauty brands. It is not difficult to find out through the four issues of the list that hyaluronic acid has taken the first place in the Light medical cosmetology industry.

How did hyaluronic acid achieve a production ratio of 1: 1111?

Hyaluronic acid is a linear polysaccharide existing in human body, which is widely used in medicine, cosmetics, food and other fields because of its good water absorption and viscoelasticity.

In 1934, Karl Meyer, an American university professor, discovered for the first time that there was a substance in the eyeball, knee synovial fluid and skin of human beings and other animals that could catch moisture, moisturize and lubricate. He named this substance "hyaluronic acid", which was later commonly known as "hyaluronic acid".

One molecule of hyaluronic acid can lock up 1111 water molecules, while a small molecule of hyaluronic acid can penetrate into the basal layer of skin to replenish skin moisture, while a large molecule of hyaluronic acid stays in the epidermis to prevent water loss.

The most important thing is that hyaluronic acid is a self-contained substance of human body, which has good biocompatibility, so there is no need to worry about rejection. These characteristics make hyaluronic acid undoubtedly an excellent moisturizing ingredient.

In 1985, Shiseido took the lead in preparing hyaluronic acid by microbial fermentation. In 1985, Zhang Tianmin developed China's first hyaluronic acid injection for ophthalmic surgery, which laid the foundation for HA research and clinical application in China, and successfully completed the research on hyaluronic acid production by fermentation in 1992.

Hyaluronic acid, which could only be extracted from cow's eyes and cockscomb, was obtained by fermentation, which reduced the production cost of hyaluronic acid at once, and ushered in the era when the public could enjoy the hyaluronic acid bonus. In 2111, Guo Xueping, the chief scientist of Huaxi Bio-technology, developed the world's first microbial enzyme digestion technology to produce full molecular weight HA on a large scale.

Hyaluronic acid has two main uses in medical beauty. First of all, hyaluronic acid is the main component of water-light needle, and its main function is to moisturize and replenish water. Two days ago, Lin Yun, a star girl, showed a video of herself playing a water-light needle in Xiaohongshu. In fact, she injected hyaluronic acid directly into the dermis, which played a direct role in replenishing water. As can be seen from the comments, consumers now have a high acceptance of water-light needles.

However, hyaluronic acid is far more than the basic function of "hydrating and moisturizing". Cross-linking technology unites the molecules of hyaluronic acid into a jelly-like plastic gel, which not only strengthens the supporting force of hyaluronic acid, but also slows down the absorption time, making hyaluronic acid a good filling material. Hyaluronic acid has a natural lytic enzyme "hyaluronidase". Compared with silica gel and bulking filling, injection of hyaluronic acid has almost no plastic risk, so it is widely used in medical beauty filling. Hyaluronic acid can not only pad the bridge of the nose and chin, but also improve static lines, which is deeply loved by beauty seekers.

According to statistics, in 2118, 21 million people in China received medical beauty treatment, among which hyaluronic acid filling became the most popular medical beauty project in China. Hyaluronic acid is listed as one of the four major inventions of medical beauty in the 2121 White Paper on New Oxygen Medical Beauty Industry.

From Huaxi Bio to Aimeike, leading enterprises led hyaluronic acid to hold its head

In 2119, the global hyaluronic acid raw material market sold 581 tons, with a compound growth rate of 21% from 2115 to 2119. According to Frost &; According to Sullivan's data, the market size of hyaluronic acid raw materials in China was 1.73 billion yuan in 2114, and it increased to 3.43 billion yuan in 2119, with a compound annual growth rate of 14.7%. According to ISAPA data, in 2119, hyaluronic acid injection accounted for 41% of plastic injection projects worldwide.

China is the world's largest producer of hyaluronic acid raw materials, which almost monopolizes the global production of hyaluronic acid raw materials. According to Frost &; According to Sullivan's data, the top five global hyaluronic acid raw material sales in 2121 are all from China. The total market share (CR5) is as high as 75%.

The preparation technology of hyaluronic acid in China is developed from Shandong Institute of Biomedicine, so the supply capacity of hyaluronic acid is concentrated in Shandong. Among them, Huaxi Bio is the world's largest hyaluronic acid production and sales enterprise. After the acquisition of Dongchen Bio, the output accounted for 43%.

The fermentation yield of Huaxi biological hyaluronic acid is as high as 1.2-1.4g/L, and the production scale and yield of hyaluronic acid are at the leading level in the world. The production capacity of hyaluronic acid will be 321 tons/year in 2121.

Relying on the advanced hyaluronic acid cross-linking technology platform, Huaxi Bio has become the leading provider of hyaluronic acid medical terminal products and functional skin care products in China, forming a brand matrix with brands such as "Runbaiyan" and "Kwadi" as the core; And continue to apply bioactive substances to medical terminal products, functional skin care products and foods, and strive to build an ecological circle of bioactive substances.

Huaxi Bio's brand "Runbaiyan" was listed in the mid-term of the American business list, and won the top three three times, which shows its position in the hearts of consumers.

When it comes to hyaluronic acid brands, we have to mention the "neck-removing artifact" that won the first place in hyaluronic acid category four times in the American business list-"Hi-body".

"Hi Body" is the first commercial skin filler for repairing neck lines in China and the only commercial skin filler with this effect in the global market at present. The appearance of the scorpion also made anti-aging enter the "face and neck era", and the injection site of hyaluronic acid also expanded from the face to the neck.

There are many hyaluronic acid products of Aimeike, which are divided into gel and solution according to their physical state. The solution includes Hi and Yimei, and the gel is Bonida, Aifulai, Aimeifei and Yimei One Plus One. Among them, Avery is also on the American business list every time.

The "import myth" has not been broken, and domestic hyaluronic acid needs to strengthen the terminal brand building

Although domestic hyaluronic acid occupies the market in the raw material end, it has no obvious advantage in the terminal products. Compared with the United States, Japan, South Korea and other countries, China's medical beauty industry started late, and the brand recognition of domestic medical beauty hyaluronic acid terminal products is not as good as that of imported products. The domestic hyaluronic acid terminal products market is still dominated by imported brand products from the United States, South Korea and Sweden, and foreign brands accounted for about 68% of the market share in 2119.

As of September 2121, there are 18 companies that have obtained HA injection certificates in China, 8 of which are imported and 11 are made in China, and 27 brands of hyaluronic acid for injection have been approved by NMPA. Among them, Joyaden is a high-end product, Yiwan and restylane are high-end, and other brands are positioned at the low end.

Domestic brands focus on the low-end route, and the unit price of products is relatively low, most of them are 311-8111 yuan, and the competition is fierce. Foreign brands dominate mid-to high-end products, while American brand "Qiao Yadeng" dominates the high-end market with a unit price of 8,111-21,111 yuan. Among the domestic brands, only the "Bonida" of Aimeike has entered the high-end product line of more than 11,111 yuan.

In consumers' minds, "domestic" has been associated with "low price", while in the high-end market, brands such as American Joarden and French Philodendron have occupied consumers' minds. In the terminal market, domestic brands still need to strengthen brand building, support by science and technology, enhance brand premium ability and gain a place in the high-end market.

In the fourth issue of the US business list in March, besides hyaluronic acid, the list of institutions and doctors was also full of bright spots. During the closure of Shenzhen due to the epidemic, Shenzhen Pengcheng Medical Beauty won the first place in the list, which seems to confirm the "lipstick effect"-when the economic crisis comes, the sales of lipstick cosmetics will increase, and beauty can alleviate the psychological anxiety of socialization.

In addition, the slap that saved the ratings of the Oscar ceremony also put hair transplant institutions and projects on the list of American businessmen that week. As the weather gets warmer, slimming projects are gradually put on the agenda by beauty seekers.

References:

Special Report on Medical and Beauty Industry (III)-hyaluronic acid industry analysis red book China Merchants Securities

Love beauty: leading the trend of medical and beauty

Bank of China International

Diversification and globalization, the rising medical care in Ran Ran.