A new breakthrough in the field of diabetes treatment
—— The Department of Hematology and Endocrinology of Aerospace Center Hospital successfully completed the first case of autologous peripheral blood stem cell transplantation to treat diabetes
At present, the prevalence of diabetes is increasing rapidly, but there is no radical treatment except controlling symptoms. Islet transplantation and pancreatic transplantation cannot be widely used because of their inherent two problems that cannot be overcome at present, namely, insufficient donors and immune rejection. In recent years, the progress of stem cell research has provided us with a new way. Autologous stem cell transplantation via artery is a new frontier technology that is expected to cure diabetes in the world. Through this treatment, it is expected to reduce the insulin dosage of patients or even stop insulin injection to achieve the purpose of controlling blood sugar to be normal or close to normal and reducing diabetes-related complications. At present, the short-term efficacy and safety of autologous bone marrow stem cell transplantation in the treatment of diabetes have been clinically confirmed, but many patients are unwilling to accept it because it requires about 5ml of bone marrow, while autologous peripheral blood stem cell transplantation has the advantages of little injury, no pain and simple operation, but there is no relevant report on this technology at home and abroad.
The Department of Hematology and Endocrinology of Aerospace Center Hospital, led by Director Wang Yizhong, absorbed the experience of autologous bone marrow stem cell transplantation in treating diabetes, explored a new scheme including stem cell mobilization, stem cell collection and stem cell implantation, and successfully applied it in clinic. On the afternoon of January 13th, 29, after five days of stem cell mobilization, a 56-year-old patient with type 2 diabetes was successfully collected with COM.TEC blood cell separator for the first time, and 135ml of stem cell suspension was obtained. On the morning of January 14th, with the assistance of Qu Tao, deputy chief physician, and Jin Weihua, the arterial catheter stem cell transplantation was performed in the interventional center of our hospital. The operation process was smooth, and the patient returned to the ward safely without any postoperative complications and discomfort. We will continue to observe the clinical curative effect in the next step and make follow-up reports.
CCTV-1 "Encyclopedia Exploration" will soon report on the treatment of diabetes by autologous stem cell transplantation in the Department of Hematology and Endocrinology in our hospital. Welcome to watch!
Program schedule:
How to perform autologous stem cell transplantation will be premiered at 14: 5 on June 13th (Saturday)
It will be replayed at 17: 3 on June 14th (Sunday)
Address of Space Center Hospital: No.15 Yuquan Road, Haidian District, Beijing: 149 P.O. Box: 861-5997199.
According to different methods of autologous stem cell collection, it can be divided into bone marrow stem cell transplantation and peripheral blood stem cell transplantation. In the former, about 5ml of autologous bone marrow was collected under aseptic conditions, and cell suspension containing enough stem cells was made through separation and purification. The latter is to inject granulocyte colony stimulating factor (G-CSF) into patients for 5-6 days to mobilize bone marrow stem cells to enter peripheral blood to make them reach a certain amount, and then use a blood cell separator to separate the needed stem cells for transplantation.
When using autologous stem cell transplantation to treat diabetes, we will migrate the stem cell suspension prepared by the above method into pancreatic tissue through arterial catheter, and differentiate and proliferate into islet-like cells and secrete insulin under the induction of pancreatic tissue microenvironment.
In the treatment of diabetic foot, there are two methods of autologous stem cell transplantation: local injection of lower limb muscle and arterial catheter injection of lower limb. Two different transplantation methods have achieved satisfactory clinical results.