The mechanism of colchicine is: (1) inhibiting granulocyte infiltration and leukocyte chemotaxis, and combining with neutrophil tubulin subunit to change cell membrane function, including inhibiting neutrophil chemotaxis, adhesion and phagocytosis; (2) inhibiting phospholipase A2, reducing the release of prostaglandin and leukotriene from monocytes and neutrophils; (3) Inhibit the production of IL-6 by local cells, so as to control local pain, swelling and inflammatory reaction of joints. Colchicine is used for acute attack and prevention of acute gout and gouty arthritis.