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Pharmacokinetics of naproxen sodium for injection
It is reported in the literature that the plasma concentration of this product reaches its peak at 15 minutes after intravenous injection, and its half-life (t 1/2) is 12- 14 hours. When the therapeutic concentration is reached in vivo, 99% of naproxen binds to plasma protein, and 95% of the product is excreted from urine in the form of naproxen or its metabolite 6-O- demethylnaproxen and their combinations. It can be excreted from milk through the placenta. It does not affect the metabolism of various enzymes and has no accumulation in the body.