Dyspepsia, abdominal distension and other atypical symptoms may appear in the early stage of hepatolenticular degeneration. Generally, it is gradually relieved or aggravated, and some people make rapid progress. In addition, typical manifestations include neuropsychiatric symptoms, abnormal liver function and corneal KF ring, and corneal pigment ring is an important sign of this disease, with an incidence rate of more than 95%. K-F ring, located at the junction of sclera and cornea, is greenish brown or dark brown with a width of about 1.3mm, and is deposited by copper in the posterior elastic membrane.
Of course, hepatolenticular degeneration may have other manifestations, such as arrhythmia, cardiomyopathy, autonomic nervous dysfunction, etc. Most patients have skin pigmentation; Pancreas is damaged; The nail arc turns blue and the copper content increases; Young women have amenorrhea, male growth retardation and breast development.