It is also the most common acute leukemia in adults. At present, its treatment is still mainly chemotherapy, but about 70% of patients who get remission eventually relapse and evolve into refractory leukemia, leading to treatment failure and death.
Extended data:
Etiology of acute myeloid leukemia
The etiology and pathogenesis of leukemia are very complicated. Although great progress has been made in this field, the etiology of leukemia is still not fully understood. At present, it is believed that most leukemia is caused by the interaction between environmental factors and the genetic material of cells.
1, the occurrence of acute myeloid leukemia is related to ionizing radiation, such as various rays. It has been reported that the incidence of CML in atomic bomb survivors in Hiroshima and Nagasaki, Japan, was significantly higher than that in other populations in 945 and lasted for decades. It can be confirmed that radiation injury is the pathogen of CML.
2. Chemical substances such as paint, benzene and hair dye can also induce leukemia by damaging bone marrow. A recent survey report in Beijing found that many children with leukemia had done interior decoration within half a year.
3. Cytotoxic drugs cause disease: Acute leukemia may be related to oral chloramphenicol, and others include aminopyrine, metamizole, sulfonamides and phenylbutazone.
4. Virus infection: Studies in recent ten years suggest that leukemia is probably caused by virus. Viruses cause leukemia in birds, mice, rats, guinea pigs, cats, dogs, cows, pigs and monkeys. In addition, it is currently believed that class C RNA tumor viruses are related to the etiology of human leukemia.
5. Genetic factors: It is reported that the incidence of leukemia in congenital dementia-like type is 15-20 times higher than that in normal children, and there are a few familial and congenital leukemia.
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