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Effect of sulforaphane (SFN) on Helicobacter pylori
Fahe and other scientists have tested the bacteriostatic effect of sulforaphane (SFN) on various clinical isolates of Helicobacter pylori and three reference strains of Helicobacter pylori, and also studied the effect of sulforaphane on the formation of gastric tumor in the classic mouse model of benzo [a] pyrene in gastric precancerous lesions. The results showed that sulforaphane showed high antibacterial activity against all 48 tested strains at neutral pH, and all 48 strains were sensitive to amoxicillin, among which 23 strains were also sensitive to clarithromycin and metronidazole. Among the remaining 25 strains, 1 1 was resistant to clarithromycin, 8 strains were resistant to metronidazole and 6 strains were resistant to both drugs. The inhibitory effect of sulforaphane has nothing to do with the resistance of these strains to other antibiotics. In addition, sulforaphane showed high inhibitory activity against clarithromycin-resistant strains and metronidazole-resistant strains. In addition, the chemoprotective anti-tumor effect of sulforaphane is attributed to its effective induction of 2-phase detoxification enzyme in rodent tissues. The forestomach of mice responds to sulforaphane by up-regulating the genes controlling glutathione transferase, NAD(P)H: quinone reductase and other two-phase proteins.

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Fah J W, harristo x, Dolan P M, et al. Sulforaphane inhibits extracellular, intracellular and antibiotic-resistant strains of Helicobacter pylori, and prevents stomach tumor induced by benzo [a] pyrene. [J]。 Journal of National Academy of Sciences, 2002,99 (11): 7610-7615.