The liver and ovary of puffer fish are the most toxic. The puffer fish was frozen in the refrigerator for a period of time, some cells were destroyed, and toxins may enter the puffer fish meat. Tetrodotoxin is extremely toxic. In order to avoid puffer fish poisoning, toxic organs should be removed before freezing, and then put into the freezer for freezing after simple cleaning. It is best to thaw puffer fish with cold water, so that the food will taste more delicious.