2. Some people are in good health and have no symptoms of discomfort after taking folic acid, while some people may have adverse reactions. Common side effects such as allergic reactions are rash, itching, swelling, dizziness and difficulty breathing. In case of allergic reaction, you must stop taking medicine and seek medical advice immediately. In addition, long-term use of folic acid can also lead to gastrointestinal dysfunction, causing nausea, bloating, loss of appetite, and yellow urine color.