The malignant degree of poorly differentiated gastric adenocarcinoma is relatively high, and it is generally in the middle and late stage when it is found, with rapid onset and poor prognosis. Therefore, the treatment of poorly differentiated gastric adenocarcinoma is relatively difficult. Surgical resection is the main treatment for early poorly differentiated gastric adenocarcinoma. All patients with poorly differentiated gastric adenocarcinoma who have no obvious signs of metastasis and no serious organic lesions in important organs should be explored by laparotomy. After the operation of early poorly differentiated gastric adenocarcinoma, radiotherapy, chemotherapy, traditional Chinese medicine and immunotherapy can be supplemented according to the thoroughness of the operation and the patient's physical tolerance to prevent recurrence.

The treatment of poorly differentiated gastric adenocarcinoma in the middle and late stage advocates multi-method comprehensive treatment. Most of the poorly differentiated gastric adenocarcinoma in the middle and late stage has spread and metastasized, so it is difficult to remove it surgically. Even if the patient can tolerate the operation, it is only palliative resection. At this time, the treatment of poorly differentiated gastric adenocarcinoma in the middle and late stage should combine various methods to learn from each other and give full play to their respective advantages. Gastric poorly differentiated adenocarcinoma is not sensitive to chemotherapy. When used in the treatment of poorly differentiated gastric adenocarcinoma in the middle and late stage, it can shrink the tumor to a certain extent and create opportunities for surgery. It can also be used to control the development of the disease and prolong the survival time after palliative surgery. Gastric poorly differentiated adenocarcinoma is sensitive to radiotherapy and can be used before and after operation. Preoperative radiotherapy for poorly differentiated gastric adenocarcinoma can shrink the tumor and increase the chance of surgical resection. Postoperative radiotherapy for poorly differentiated gastric adenocarcinoma can eliminate possible residual lesions and prevent metastasis and recurrence.