The side effects of taking metformin tablets are mainly the stimulation of the stomach, fatigue, dizziness, etc. Long-term use can produce anemia symptoms, and long-term use of large quantities or even lactic acidosis. Taking metformin enteric-coated tablets or metformin extended-release tablets can reduce the stimulation of the stomach. Metformin tablets adverse reactions, contraindications, precautions: Adverse reactions 1 common: nausea vomiting diarrhea metallic taste in the mouth 2 sometimes have fatigue fatigue dizziness rash 3 lactic acidosis although the incidence is very low, but to pay attention to the clinical manifestations of vomiting abdominal pain hyperventilation mental disorders increase in the concentration of lactic acid in the blood can not be used to explain the uremic ketoacidosis or salicylate intoxication 4 may reduce the absorption of vitamin B12 to reduce the blood protein, resulting in a decrease in vitamin B12 absorption. 4 Reduced absorption of vitamin B12 Reduced hemoglobin Produces megaloblastic anemia May also cause malabsorption Contraindications: 1 Type II diabetes mellitus with ketoacidosis Hepatic and renal insufficiency (serum creatinine greater than 1.5 mg/dl) Lung insufficiency Heart failure Acute myocardial infarction Severe infections and traumatic injuries Major surgery, as well as clinical hypotension and hypoxia 2 Diabetes mellitus in combination with severe chronic complications (e.g., diabetic nephropathy, diabetic ophthalmopathy, diabetes mellitus) Diabetic nephropathy Diabetic fundopathy) 3 Prior to intravenous pyelography or arteriography 4 Alcoholics 5 Patients with severe cardiopulmonary disease 6 Patients with vitamin B12, folate and iron deficiencies 7 Patients with poor general health (e.g., malnutrition, dehydration) Precautions 1 Type I diabetes should not be treated with this product alone (it may be used in combination with insulin). 2 Check fasting blood glucose, urine glucose and urine ketone bodies frequently, and measure blood creatinine and blood lactate concentration regularly during administration. 3 Prevent hypoglycemic reactions when used in combination with insulin for treatment. Drug interactions 1 Combined with insulin, the hypoglycemic effect is enhanced, and the dose should be adjusted. 2 This product can enhance the anticoagulant effect of anticoagulants (e.g., warfarin, etc.), which may lead to hemorrhagic tendency. 3 Cimetidine can increase the bioavailability of this product and reduce renal clearance, so the dose of this product should be reduced

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