2 English reference Danggui Sini Decoction [2 1 Century Bilingual Dictionary of Science and Technology]
Danggui Sini Decoction. Terminology of Traditional Chinese Medicine (2004)]
There are about 6 prescriptions of the same name in Danggui Sini Decoction, among which the prescription recorded in Treatise on Febrile Diseases is a common prescription, which consists of Danggui 12g, Guizhi 9g, Paeonia lactiflora 9g, Asarum 3g, Radix Glycyrrhizae preparata 6g, medulla tetrapanacis 6g, and Zizyphus jujuba 8 pieces. It has the effects of warming the middle warmer, dispelling cold, nourishing blood and activating pulse. Indications are blood deficiency and cold syndrome caused by blood deficiency and cold pathogen stagnation in meridians. It is a representative prescription for treating blood deficiency and cold syndrome. It is often used to treat thromboangiitis obliterans, Raynaud's disease, lower limb paralysis in children, pulseless disease, chilblain, dysmenorrhea and so on.
4 Danggui Sini Decoction in Treatise on Febrile Diseases can directly target the pathogenesis of thromboangiitis obliterans, pulseless disease and Raynaud's disease, but the therapeutic mechanism of infantile limb coldness, thin or thin pulse and heartburn caused by polio needs further study [1]. In addition, for severe cases, it is necessary to cooperate with modern medical thrombolytic therapy and immune preparation [1].
4. 1 Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Paeoniae Alba, Herba Asari, Radix Glycyrrhizae Preparata, Caulis Akebiae (now Akebiae), and Fructus Jujubae 25 pieces (12 pieces in one method) [2].
Angelica sinensis 12g, Cinnamomum cassia twig 9g, Radix Paeoniae Alba 9g, Asari 3g, Radix Glycyrrhizae preparata 6g, medulla tetrapanacis 6g, and 8 Chinese dates [3].
Angelica sinensis, Cinnamomum cassia twig (peeled), Radix Paeoniae Alba, Herba Asari, Radix Glycyrrhizae (parched), medulla Tetrapanacis, and Fructus Jujubae (broken, one method, 12 pieces) [4].
4.2 Efficacy Danggui Sini Decoction, which is mainly used in Treatise on Febrile Diseases, has the functions of warming channels and dispelling cold, nourishing blood and dredging veins [2]. Indications: blood deficiency, aversion to cold, cold hands and feet, pale tongue with white fur and thready pulse, or menoxenia caused by blood deficiency and cold coagulation, cold pain in the stomach, cold entering the collaterals, lumbago, leg and foot pain, etc. Modern is also used for fingertip artery spasm (Raynaud's disease) and chilblain [2].
Danggui Sini Decoction, a prescription of Treatise on Febrile Diseases, has the effects of warming middle warmer, warming channels and dispelling cold, nourishing blood and dredging veins. Indications: syndrome of blood deficiency and cold Jue. Symptoms include blood deficiency with cold, cold hands and feet, dry mouth without thirst, pain in the waist, legs and feet, numbness, pale tongue with white fur, thin or thin pulse, twisted heart, and cold entering the meridians. Now used for early Raynaud's disease and frostbite.
4.3 Usage of Danggui Sini Decoction: decoct in water, remove dregs, and take it three times [2].
Take 8 liters of water, boil 3 liters, take me, temperature 1 liter, three times a day.
Take eight liters of water, boil three liters, warm one liter, three times a day [4]
4.4 Danggui Shaoyao Prescription regulates liver blood; Guizhi and Asari warm meridians to dispel cold; Radix Glycyrrhizae Preparata and Fructus Jujubae tonify middle energizer, strengthen spleen and tonify qi and blood, while Rhizoma Alismatis and Radix Paeoniae can better coordinate camp and health. Akebia manshuriensis combined with various drugs to promote blood circulation [2]. All the drugs are used together to form the agent for warming and invigorating the pulse [2].
This recipe was originally used to treat cold hands and feet and rapid pulse [5]. This is the syndrome that blood deficiency brings cold, blood cold stagnates, blood is weak and does not support limbs, and cold hinders Yang Qi from warming the four ends. At this time, you can see that your hands and feet are cold and your pulse is rapid [5]. However, although the pulse condition is weak, there is no other manifestation of light yang and heavy yin, but it can be seen that the cold is in the meridians and the blood vessels are unfavorable [5]. At this time, it is necessary to warm the meridians and dispel the cold, but also to nourish the blood and dredge the pulse [5]. This prescription consists of Guizhi decoction to remove ginger, jujube to add angelica, medulla tetrapanacis and asarum [5]. Blood deficiency and cold coagulation, so using Radix Angelicae Sinensis to enter the liver and replenish blood is an important drug to warm and replenish the liver meridian; Ramulus Cinnamomi is warm in nature, warming the meridians and dredging the veins, so as to dispel the cold evil left by the guests in the meridians and make the blood circulation smooth. The combination of the two flavors is the method of nourishing blood and warming the veins [5]. Taking Radix Paeoniae Alba and Asari as ministers, Radix Paeoniae Alba nourishes blood, reconciles with Radix Angelicae Sinensis, enriches blood, and reconciles qi and blood with Ramulus Cinnamomi; Asarum pungent warming, external warming meridians, internal warming viscera, reaching the exterior and interior, in order to dispel cold pathogens, can help Guizhi warm meridians and dispel cold [5]. Cao Tong is an assistant to dredge meridians [5]. Licorice and jujube are sweet, benefiting qi and strengthening the spleen, harmonizing various medicines, and reusing jujube can not only help cinnamon, less blood, but also prevent cinnamon and pungent dryness from overflowing and avoid hurting yin and blood, which is thought to make [5]. All the medicines are combined, warm but not dry, nourishing but not stagnant, * * * plays the role of warming meridians and dredging veins, so that yin and blood are filled, guest cold is removed, Yang Qi vibrates, meridians are unblocked, hands and feet are warm, and veins are restored [5].
The ratio of Ramulus Cinnamomi to Radix Paeoniae Alba in this prescription is 1: 1, which is the method of nourishing blood and warming meridians for Ramulus Cinnamomi and Angelica sinensis. Radix Paeoniae Alba nourishes blood and helps Angelica enrich blood [3].
4.5 Danggui Sini Decoction is a representative prescription for treating blood deficiency and cold Jue syndrome [3]. The clinical manifestations are syncope of hands and feet, pale tongue with white fur, deep and thin pulse and heartache, which can be treated with this recipe.
Addition and subtraction: if it is pain in waist, thigh, legs and feet caused by blood deficiency and cold coagulation, Radix Dipsaci, Achyranthis Radix and Caulis Spatholobi are added to promote blood circulation, remove blood stasis and relieve pain; Female dysmenorrhea is caused by blood deficiency and cold coagulation. Aconitum carmichaeli and Linderae are added to isothermal menstruation to promote qi circulation and relieve pain. Or male patients with cold hernia, testicular pain, less traction abdominal pain, cold pulse in limbs, Lindera root, fennel, Alpinia officinarum, Rhizoma Cyperi, etc. Adding regulating qi to relieve pain; For chilblain of hands and feet, notopterygium root, pubescent angelica root and angelica dahurica can be added to dispel cold and relieve pain, regardless of whether it has ulcerated in the early stage [3]. Adding Evodia rutaecarpa and ginger can cure chronic cold and vomiting caused by drinking water. It can also be used to treat menstrual abdominal pain caused by blood deficiency and cold coagulation in women, cold hernia, testicular pain and traction abdominal pain in men [5].
Note: This prescription is only applicable to limb coldness caused by blood deficiency and cold coagulation, not to limb syncope caused by other reasons. This prescription should not be used for damp-heat arthralgia.
Danggui Sini Decoction for Blood Bi: Patient Zhou, female, 25 years old. Wake up at night, my hands are numb, like ants walking, my fingers are not moving, it is inconvenient to hold the needle, but my grip is still there. My hands are cold, and so is my tactile pain. The pulse is thin and slightly tight, and the tongue is pale with white fur. This cold pathogen is stagnant, the meridians are blocked, the blood circulation is not smooth, and the collaterals of the limbs are not healthy. The prescription is treated with Chuanxiong, Astragalus and Ephedra. Symptoms were relieved after two doses, and recovered after three doses.
Danggui Sini decoction in the treatment of early Raynaud's disease: the pathogenesis of this disease is yang deficiency, inability to warm and nourish the four ends, invasion of cold pathogens and blood stasis. Danggui Sini decoction is quite suitable when using drugs that warm yang, promote blood circulation, dispel cold and disperse stagnation. Two cases were treated with this prescription, and the original prescription was cured by adding more than 30 doses of Artemisia argyi safflower 1 case. After taking 18 dose, it was cured 1 case. No recurrence was found during follow-up.
Danggui Sini decoction for thromboangiitis obliterans: 65438 cases in this group. The symptoms are syncope of lower limbs, severe pain and thready pulse, and the course of disease is 3 years and 2 months respectively. This recipe is used together with Fu Jie Decoction and Simiao Yong 'an Decoction. Results: 9 cases were cured and improved 1 case.
Danggui Sini Decoction for chilblain: Zhao, male, over 30 years old. The snow fell heavily, frozen on the ground, climbed for miles, and lay on the ground waiting for death. The neighbors found it and carried it back, and their hands and feet were rebellious, making it difficult to turn over and pull over. This frostbite, thrown into our own prescription, is measured by the temperature of the limbs when syncope. After four doses, my body turned into purple bubbles like walnuts and frostbite. You can transfer it in a few days, and it will be fine in a month. (Yue Meizhong's medical record)
4.6 Modern indications [6]
Danggui Sini Decoction is suitable for patients with thromboangiitis obliterans, pulseless disease, Raynaud's disease, infantile lower limb paralysis, etc.
4.6. 1 thromboangiitis obliterans is an inflammatory, periodic and chronic occlusive disease involving blood vessels, mainly invading arterioles and veins of limbs, especially lower limbs. The exact cause of the disease is not clear, which may be related to the following factors: ① External factors, such as smoking, cold, humidity, chronic injury, infection, etc. Tobacco extract can cause vasculitis in experimental animals. ② Because of autoimmune disorder, antinuclear antibodies can be found in patients' serum, and immunoglobulin and C3 complex can be found in arteries, all of which support immunity. The imbalance of sex hormones and prostaglandin and heredity may also be related to this disease. Lesions usually start from arteries, then involve veins, and develop from distal to proximal. The lesions were distributed in stages, and the active stage was full-thickness non-suppurative inflammation of blood vessels, proliferation of endothelial cells and fibroblasts, and blockage of lumen thrombus. In the later stage, inflammation subsided and new capillaries formed. The main clinical manifestations are that the affected limb is afraid of cold, the skin temperature drops, the skin color is pale or blue, the sensation is abnormal, the affected limb is painful, and malnutrition occurs after long-term ischemia and hypoxia. In severe cases, ischemic ulcer or gangrene occurs, and the arterial pulse disappears or weakens when touched.
4.6.2 Atherosclerosis actually refers to Takayasu's arteritis, which is the chronic progressive and nonspecific inflammation of the aorta and its main branches, leading to arterial stenosis or occlusion in different parts. A few may have arterial dilatation or aneurysm, and ischemia appears in the corresponding part. People usually call it "pulseless disease". The etiology is still unclear, and it is mostly related to genetic and endocrine abnormalities and immune dysfunction after infection. It mainly involved the elastic artery, and mostly invaded 1 ~ 3 artery. The lesion is more obvious at the beginning of aortic branch, spreading from the middle and adventitia of artery to intima. The whole arterial wall showed irregular proliferation and fibrosis in stages, and the lumen was narrow or occluded in different degrees, sometimes complicated with thrombosis. The basic pathological changes are exudation, chronic nonspecific inflammation and granuloma. The main clinical manifestations are fever, general malaise, weight loss and other systemic symptoms. Patients with aortic arch syndrome are characterized by dizziness, headache, blurred vision, repeated syncope, convulsion, hemiplegia, numbness and pain of corresponding limbs, weakening or disappearance of arterial pulsation, and decreased blood pressure of affected limbs. ① Thoracoabdominal aortic type: manifested as ischemia of both lower limbs, weakness of both lower limbs, chills and soreness, limping, vascular murmur audible in abdomen, and elevated blood pressure of both lower limbs.
4.6.3 Raynaud's syndrome's disease and Raynaud's disease Raynaud's syndrome and Raynaud's disease refer to patients' fingers (toes) turning pale after catching cold or nervous, then turning purple and red, accompanied by temporary clinical phenomena such as local chills, paresthesia and pain, which often recur. Those without other primary diseases are Raynaud's disease, and those with definite secondary diseases are Raynaud's disease. There is no consensus on the etiology so far, and some people think that it is caused by excessive sympathetic nerve activity; Some people think that the pathological changes of arterial wall lead to the overreaction of peripheral blood vessels to cold and emotional stress. At present, it is considered that the abnormal function of vascular endothelial cells is the pathophysiological basis of this disease. There were no pathological changes in the early stage, and vascular endothelial thickening, distal finger pulp atrophy and distal bone resorption occurred in the elderly. In severe cases, fingertip ulcers and gangrene occur.
4.6.4 Polio, polio, is an infectious disease spread by poliovirus through digestive tract or respiratory tract. After the virus invades the human body, it invades the nervous system with secondary viremia, which leads to the injury of motor neurons in the anterior horn of spinal cord, pathological changes of nerve cells, congestion and edema of local tissues and inflammatory infiltration around blood vessels. In severe cases, nerve cells are necrotic, forming scars, leading to persistent paralysis, mostly manifested as asymmetric paralysis of one limb, muscle atrophy and limb paralysis in sequelae.
4.7 pharmacological effects of Danggui Sini decoction [7]
4.7. 1 Influence on immune function The monarch drug Angelica sinensis can obviously promote the immune function of the body. Its effective component is Angelica sinensis immunoactive polysaccharide, which has immune adjuvant-like activity, activates complement through classical ways, has good complement activity and has good interferon induction activity; Angelica sinensis immunoactive polysaccharide can also significantly improve the functional activity of mononuclear phagocytes, increase the content of NO, enhance their ability to secrete TNFα and IL 1, and have an antagonistic effect on the inhibition caused by glucocorticoid. Angelica sinensis immunoactive polysaccharide has a strong activation effect on lymphocytes, which can promote the mitotic activity of human spleen cells and make B lymphocytes differentiate into different mature stages, and some cell groups mature into antibody-secreting cells. Angelica sinensis immunoactive polysaccharide can also directly activate T lymphocytes involved in antibody reaction, enhance the function of cytotoxic T cells, increase their killing activity and obviously promote the proliferation of spleen lymphocytes. Moreover, ferulic acid contained in Angelica sinensis has broad-spectrum antiallergic effect, but has no inhibitory effect on immune function; Ferulic acid can inhibit type ⅰ, ⅱ, ⅲ and ⅳ allergic reactions, which may be related to its ability to stabilize cell membrane, inhibit mast cell degranulation and reduce the release of inflammatory mediators. Type ⅱ allergic reaction is cutaneous vasculitis, and active and passive Arthos reactions belong to type ⅲ allergic reaction. Inhibition of type ⅱ and ⅲ allergic reactions may be related to the anti-inflammatory effect of Angelica sinensis. Cinnamomum cassia twig can inhibit complement activity, degranulation of mast cells caused by IgE and release of allergic mediators such as histamine, so it has strong anti-allergic effect. The total glucosides of paeony contained in the decoction of Paeonia lactiflora have a direct activation effect on macrophages, and further research shows that the total glucosides of paeony have a biphasic regulation effect on macrophages; In vivo and in vitro experiments show that TGP has a function and concentration-dependent biphasic regulation on T cell function. The biphasic regulation of humoral immunity is also related to the influence of TGP on T-regulatory cells, that is, the positive and negative regulation of antibody production by TGP is related to its regulation of TH and ts, and TGP can restore the cellular immune function to normal under immune impairment. TGP's bidirectional regulation of pituitary-adrenal axis may be another way to regulate immune function. In addition, acidic polysaccharide PeonanSB and neutral polysaccharide PeonanSA isolated from Paeonia lactiflora have the activation effect of reticular endothelial system. The total polysaccharide of medulla tetrapanacis can improve serum lysozyme activity, phagocytosis of reticuloendothelial system and monocytes, serum antibody level and inhibit delayed allergic reaction. Jujube can improve the phagocytic function of monocyte-phagocyte system in vivo, promote hemolysis and hemolytic plaque, promote lymphocyte transformation, improve the decomposition of peripheral blood lymphocytes and promote lymphocyte proliferation, and has obvious anti-complement activity and anti-type I allergic effect. Glycyrrhizin can inhibit the release of histamine from mast cells and enhance the secretion of IL-2 from lymphocytes induced by ConA. Glycyrrhetinic acid can increase lymphocyte ratio; Diammonium glycyrrhizinate can increase the level of interferon α in serum; β -glycyrrhetinic acid is an inhibitor of the classical pathway of human complement; Glycyrrhiza uralensis Fisch can not only induce interferon and enhance the activity of NK cells, but also contain glycyrrhizic acid, which can inhibit degranulation of mast cells and has anti-allergic effect. Glycyrrhizic acid can also increase the weight of spleen and thymus, enhance the activity of reticuloendothelial system and significantly increase antibodies in vivo. Glycyrrhiza polysaccharide can proliferate lymphocytes. Licorice Lx can not only inhibit the immune response of macrophages, but also reduce the amount of antigen to show immunosuppression and prevent penicillin anaphylactic shock. Asarum decoction can inhibit both cellular immunity and humoral immunity, but it can inhibit the release of allergic mediators and immediate allergic reaction. It can be seen that most drugs in this prescription can promote, enhance and regulate immune function, and only Asarum has inhibitory effect, but Paeonia lactiflora has strong biphasic regulation effect, which can restore the balance between the above functions and immune disorder. More importantly, the excitatory effect of Glycyrrhiza uralensis Fisch on pituitary-adrenal cortex axis and the hydrocortisone-like effect of glycyrrhizic acid can increase the amount of corticosteroids in the body, and its superior "allowing" effect can coordinate other hormones in the body, improve the endocrine regulation ability of the body, and play a therapeutic role of "strengthening the body resistance".
The effect of this prescription on immune function can be cut into the immune mechanism of thromboangiitis obliterans, pulseless disease and Raynaud's disease.
4.7.2 Anti-inflammatory and Antioxidant Effects The monarch drug Angelica sinensis has anti-inflammatory, anti-oxidation, anti-radiation and anti-chemical damage effects. Angelica sinensis decoction has obvious inhibitory effect on acute and chronic inflammation caused by various inflammatory factors, and can reduce the release of PGE2 in inflammatory tissues and the hemolytic activity of complement bypass. Angelica sinensis has a strong scavenging effect on superoxide anion and hydroxyl radical. Angelica sinensis decoction can significantly activate the activities of SOD and Ca2+ATPase in human blood and brain, and inhibit lipid peroxidation. Angelica injection can inhibit the production of plasma TXB2, increase the level of plasma 6 ketopgf Ⅰ α, correct the ratio of TXA2/GGI2 during cerebral ischemia, and reduce the mortality of cerebral ischemia. Ramulus Cinnamomi can inhibit all aspects of inflammation caused by various inflammatory substances, and can obviously reduce capillary permeability, exudation, edema and granulation tissue proliferation. Paeonia lactiflora has obvious anti-inflammatory effect, and its effective component is total glucosides of Paeonia lactiflora, which can inhibit the excessive secretion of IL 1, TNF and PGE2, increase the activities of SOD and GSHPx, and reduce the level of MDA. It has obvious inhibitory effect on experimental nonspecific inflammation and immune inflammation, and has different degrees of inhibitory effect on capillary permeability, exudation, edema and proliferation of inflammation. The water extract of Paeonia lactiflora can enhance hypoxia tolerance, reduce systemic oxygen consumption and lower body temperature; Total glucosides of paeony and paeoniflorin contained in them can scavenge superoxide anion and hydroxyl radical, and paeoniflorin can significantly inhibit the formation of lipid peroxide and the increase of SPT in liver. The volatile oil contained in Asari has obvious anti-inflammatory effect. Its mechanism of action is not only to enhance the function of adrenal cortex and promote the release of ACTH, but also to inhibit the release of inflammatory mediators in the process of inflammation. It has a strong ability to remove superoxide anion and inhibit lipid peroxidation in liver, and has a protective effect on the depolymerization of hyaluronic acid and aminopolysaccharide in arthritis induced by superoxide anion, so it has a significant inhibitory effect on all links and different stages of inflammation. Tetrapanacis tetrapanacis has obvious anti-inflammatory and detumescence effects, improves SOD activity in blood and reduces LPO content in blood and liver. Jujube polysaccharide contained in jujube can improve the activities of SOD and CAT in whole blood, scavenge free radicals, reduce the contents of MDA and LPO in brain, liver and blood, scavenge active oxygen in chemiluminescence of whole blood and inhibit oxidative damage. Glycyrrhiza uralensis Fisch has an anti-inflammatory effect similar to that of phenylbutazone or hydrocortisone, and its anti-inflammatory components are glycyrrhizic acid and glycyrrhetinic acid. By inhibiting PGE2 and reducing endogenous PGE2 production, exudation, edema, granulation tissue hyperplasia and stage I, II and III inflammation can be inhibited, as well as allergic inflammation such as Alsace phenomenon and Schwartzman reaction. The inhibitory mechanism of Glycyrrhiza uralensis Fisch on immune inflammation may be related to the following three factors: first, inhibiting the activation of fibrinolytic system; The second is to reduce the promoting effect of serum on capillary permeability; The third is to inhibit the high permeability of cell membrane. Glycyrrhizic acid and glycyrrhetinic acid can also inhibit the production of free radicals and lipid peroxides, and have antioxidant effects, which are very important for the treatment of shock and myocardial infarction.
4.7.3 Effects on heart, blood vessels and hemorheology The monarch drug Angelica sinensis has obvious antiarrhythmic effect, which can slow down conduction, prolong effective refractory period, eliminate reentry, prolong plateau period, inhibit ectopic rhythm points and raise fibrillation threshold. Angelica sinensis can increase coronary blood flow, narrow the range of myocardial infarction caused by coronary artery occlusion, protect myocardial cells from glucose deficiency and hypoxia injury, and at the same time have the effects of anti-free radicals and reducing oxygen consumption. It can stabilize myocardial cell membrane and protect the function of mitochondria, that is, lysosomes; Angelica injection protects hypoxic pulmonary hypertension by exciting β receptor. Angelica sinensis can obviously inhibit platelet aggregation, reduce blood viscosity, reduce plasma fibrinogen and prolong prothrombin time, which has antithrombotic effect. It is reported that 5% angelica injection was used to treat thromboangiitis obliterans for 4 weeks, and the effective rate was 89%. Ramulus Cinnamomi can increase coronary blood flow, increase myocardial nutritional blood flow, reduce the incidence of ventricular fibrillation after ischemia reperfusion, reduce the production of LDH, CPK and LPO in myocardium, and increase SOD activity. Reduce whole blood viscosity, reduce fibrinogen content, antithrombin, inhibit platelet aggregation, dilate blood vessels and improve peripheral circulation. The aqueous extract of Radix Paeoniae Alba can antagonize myocardial ischemia caused by pituitrin, dilate coronary artery, increase myocardial nutrient blood flow, dilate blood vessels, and inhibit platelet aggregation induced by ADP and arachidonic acid. Total glucosides of paeony can also reduce the wet weight of platelet thrombosis and inhibit thrombosis. Asarum volatile oil has positive inotropic and positive frequency effects on the heart and can increase coronary blood flow. Racemazine contained in Asari has the effects of strengthening the heart and dilating blood vessels, and can increase the average arterial pressure, left ventricular systolic pressure, coronary sinus blood flow and reduce the central arterial pressure in shock animals. Licorice contains flavonoids, which can narrow the range of myocardial infarction and antagonize arrhythmia caused by many reasons. Glycyrrhetinic acid has angiotensin ⅱ at 1 receptor agonist-like effect; Glycyrrhiza uralensis Fisch has anti-atherosclerosis effect, while glycyrrhizic acid can inhibit phospholipase A2 activity and platelet aggregation. These effects of this prescription are beneficial to the treatment of vascular stenosis and occlusion.
4.7.4 Sedation and analgesia and their effects on nervous system function. Angelica sinensis has sedative and analgesic effects. Angelica sinensis can dilate cerebral vessels, improve cerebral circulation, improve neuron metabolism, narrow the scope of cerebral infarction, promote nerve growth and repair related proteins after cerebral ischemia injury, promote the expression of neural cell adhesion molecule and microvascular related proteins, reduce apoptosis, and inhibit penumbra apoptosis by promoting the expression of bcl2; Promote nerve regeneration and reinnervation. Cinnamaldehyde contained in Ramulus Cinnamomi has obvious sedative, analgesic, antipyretic and anticonvulsant effects. Paeonia lactiflora has obvious analgesic effect, and paeoniflorin and licorice FM 100 also have obvious analgesic and sedative synergistic effects. The combination of Radix Paeoniae Alba and Radix Glycyrrhizae can treat central or peripheral muscle spasm and pain caused by spasm. Paeonia lactiflora also has anticonvulsant effect. The volatile oil of Asarum has obvious central inhibitory effect, low-dose sedative, high-dose hypnotic and anticonvulsant effects, and its effects on cerebral cortex, hippocampus and midbrain reticular structure are similar to those of barbiturates, and its analgesic intensity is equivalent to that of aminopyrine. Asari decoction also has analgesic effect. Tetrapanacis tetrapanacis has obvious antipyretic effect. Jujube has hypnotic and sedative effects. Glycyrrhiza uralensis Fisch has the unique spasmolytic ability of papaverine, so it has spasmolytic effect. Glycyrrhiza FM 100 has sedative, analgesic and anticonvulsant effects. Licorice flavonoids have protective effect on cerebral ischemia reperfusion; Intravenous drip of glycyrrhizic acid can improve the activities of mitochondrial ATPase and lactate dehydrogenase in brain tissue after ischemia-reperfusion and alleviate brain edema.
Body surface area calculator body mass index calculation and evaluation of female safety period calculator expected date calculator normal weight gain during pregnancy medication safety classification (FDA) five elements and eight characters adult blood pressure evaluation body temperature level evaluation diabetes diet suggestion clinical biochemical common units conversion basal metabolic rate calculation sodium supplement calculator iron supplement calculator prescription common Latin abbreviations quick check pharmacokinetics common symbols quick check effective plasma osmotic pressure calculator alcohol intake calculator.
Encyclopedia of medicine, count now!
4.7.5 Effect on Pathogenic Microorganisms The monarch drug Danggui Decoction has inhibitory effect on Escherichia coli, typhoid bacillus, dysentery bacillus, diphtheria bacillus, Staphylococcus aureus and Pseudomonas aeruginosa. The volatile oil of Ramulus Cinnamomi has inhibitory effects on anthrax, pneumococcus, Escherichia coli, Proteus, Vibrio cholerae, Salmonella, Shigella, typhoid and paratyphoid, Staphylococcus aureus, Staphylococcus albicans, tuberculosis, orphan virus, influenza virus and syphilis. In vitro test of Paeonia lactiflora decoction has inhibitory effect on a variety of pathogenic bacteria, except for some of the above bacteria, it has direct antiviral effect on Shigella dysenteriae, hemolytic streptococcus, streptococcus viridis, streptococcus pneumoniae, Pseudomonas aeruginosa, Bordetella pertussis, Vibrio cholerae and various fungi. The ethanol extract, volatile oil and decoction of Asarum have inhibitory effects on Gram-positive bacteria, Bacillus subtilis, typhoid fever, Aspergillus flavus and syncytial virus. Glycyrrhiza uralensis not only has inhibitory effect on some of the above bacteria, but also has inhibitory effect on Helicobacter pylori, amoeba, Clonorchis sinensis and trichomonas, and has direct broad-spectrum antiviral effect. Glycyrrhiza polysaccharide can inhibit vesicular stomatitis virus, herpes simplex virus type I and vaccinia virus. Glycyrrhizic acid has a strong ability to inhibit coxsackie virus, syncytial virus and adenovirus. Glycyrrhizic acid monoamine can inactivate HIV, and glycyrrhizin can inhibit not only the above virus, but also hepatitis virus.
4.8 Various arguments 1. "Synopsis of the Golden Chamber": Deficiency of internal yin and blood will make the pulse not proud, and deficiency of external yang will make it impossible to warm at the end of the four seasons, so the hands and feet are cold and the pulse is thin and heartbroken. Therefore, Angelica sinensis is the monarch, enriching blood, and Paeonia lactiflora is the minister, benefiting qi and supplementing it; Supplemented by the suffering of cassia twig and asarum, dispel cold and dampness; Taking jujube and licorice as ambassadors, we can take their strengths and make up their weaknesses; With the light of grass, you can feel your pulse and faint.
2. "Ancient Prescription Selection" Note: The four adverse reactions of Angelica sinensis do not need ginger and accessories, and the yin and blood are weak, which may rob its yin. Moreover, although the four adverse reactions are cold, they are not cold. As long as the Jue Yin is reconciled and the meridians are warmed, the camp can be restored. Therefore, it is necessary to use sour and sweet, sweet and warm, and contain four methods to treat the liver. The pungent taste of Guizhi is used to warm liver yang, the pungent taste of Asari is used to soothe liver yin, and the pungent taste of Angelica sinensis is.
3. The Golden Mirror of Medical Zong: This prescription takes Guizhi Tangjun as Angelica and Jueyin as the blood chamber; Asari has a very pungent taste, which can reach 3 yin. The external temperature is warm and the internal temperature is dirty. Cao Tong is extremely versatile, good at opening joints, opening to the outside world; Double dates, that is, the method of sweetening construction; Minus ginger, it will be too pungent and will soon disperse.
4.9 Songs of Angelica sinensis, Guishaozao, Asari, Glycyrrhiza uralensis and Tetrapanacis; Blood deficiency, cold liver, and limb syncope can be decocted with this recipe to take Le Tao Tao [3].
4. 10 Source Treatise on Febrile Diseases
5. Prescription of Danggui Sini Decoction written by Fang Xian in Ming Dynasty, 5. 1: Danggui, Guizhi, Paeonia lactiflora and Asarum, each with two and a half pieces. Tetrapanacis medullaris and Glycyrrhiza uralensis are one and a half yuan each.
5.2 Danggui Sini Decoction, written by Ming Fangxian, is mainly used for people with cold hands and feet and heartbroken pulse.
5.3 Usage and dosage of Danggui Sini Decoction: Take one dose, decoct in water for two minutes, and decoct one red jujube for one minute, regardless of time.
5.4 Fang Xian, the source is Ming, write down the odd side.
6 "Health Collection" Volume 18 Danggui Sini Decoction 6. 1 Prescription angelica tail 2. 1g Radix Aconiti Lateralis Preparata (processed), Cortex Cinnamomi, Fructus Foeniculi (fried), Radix Bupleuri 1.5g Radix Paeoniae 1.2g Poria, Rhizoma Corydalis, Radix Foeniculi.
6.2 Pharmaceutical Methods.
6.3 Danggui Sini Decoction has the function of indicating eighteen prescriptions in the health treasure, and is mainly used for hernia, navel and abdominal cold pain, and waist and hip traction.
6.4 Usage and dosage of Danggui Sini Decoction Use 350 ml of water, fry to 150 ml, and take it on an empty stomach.
6.5 Source: Health Care Collection Volume 18
The prescription of 20 Danggui Sini Decoction in Six Books of Medical Policy is 7. 1. Radix Aconiti Lateralis Preparata (1 qianban), Guangui (1 qianban), Radix Paeoniae Alba (1 qianban), Radix Bupleuri (5 points), Radix Angelicae Sinensis (3 money), Evodia rutaecarpa (1 money), and Neem.
7.2 Danggui Sini Decoction is mainly used for treating hernia due to yang deficiency and cold coagulation in Volume 24 of Six Books of Medical Policy, with tight and thin pulse.
7.3 Usage of Danggui Sini Decoction: decoct in water and take it warm.
7.4 All factions discuss that yang deficiency is in the lower part, cold is tied to meridians, yang deficiency cannot be applied but meridian qi is inhibited, so virtual hernia often occurs. Fuzi tonifies fire and strengthens yang, laurel warms channels and dispels cold, Angelica sinensis nourishes blood and nourishes channels, Paeonia lactiflora tightens yin and softens tendons, Bupleurum chinense elevates yang and eliminates evil, Evodia rutaecarpa descends, Alisma orientalis purges turbid yin and clears kidney, Foeniculum vulgare warms channels and benefits qi but causes hernia, and Toosendan Toosendan Fructus purges damp-heat to relieve deficiency hernia.
7.5 Source "Six Books on Medical Strategies" Volume 24
8. Danggui Sini Decoction 8. 1 is a prescription for revising Treatise on Febrile Diseases, which consists of 3 yuan, 5 points of Guizhi tip, 3 points of Herba Asari (honey-roasted), fresh onion 1 slice (cut into inches), 3 yuan, 5 points of roasted grass, and Akebia 1 yuan.
8.2 Danggui Sini Decoction, mainly used to revise the popular prescription of febrile diseases, has the effect of nourishing yin and dredging veins. Indications: cold hands and feet, rapid pulse.
8.3 For cold hernia, slight abdominal pain and foaming at the mouth, Evodia rutaecarpa is added to stop hernia pain and ginger juice to stop foaming.
8.4 In every discussion, Guizhi, Shaorong and Yangxue Tongluo are kings; I use Gui, Xin and Xin to open the channels and collaterals, so that the channels and collaterals are unobstructed and self-matched. Especially those who use crimson, onion and wine, as soon as they cross the tunnel, they will be used to open the network; The faster the grass is roasted, the faster the strength is exerted. This is a good recipe for nourishing blood and nourishing yin, activating collaterals and dredging veins.
8.5 Source Redefining Popular Treatise on Febrile Diseases
9 Xingyuan (9. 1) Hexagonal Danggui Sini Decoction is composed of Danggui 1 5, Guangui 1 5, Radix Paeoniae Alba 1 5, Herba Asari 1 5, and Radix Glycyrrhizae (fried) 1 5.
9.2 Danggui Sini Decoction has the function of indicating the six directions of the line, indicating that yin (depression) is as big as a bucket, and all drugs can't be effective.
9.3 Usage and dosage of Danggui Sini Decoction 5 slices of ginger, decocted in water and taken in the air.
9.4 sources