The toxic parts of puffer fish are liver, gonads, intestines, stomach and blood, etc. In the processing of dissecting puffer fish, it is necessary to get rid of the toxic parts, and it is necessary to do it with special people, special places, special tools, professional dissecting treatment and special cooking in order to ensure the safety

The toxicity of tetrodotoxin is more than 1,250 times higher than that of cyanide, and it is possible to kill a person with 0.5 milligrams of it. The toxin has a local stimulating effect on the intestinal tract, and after absorption, it rapidly acts on the nerve endings and nerve centers, and can block the sodium channel on the nerve excitation membrane with high selectivity and high affinity, hindering the nerve conduction, thus causing nerve paralysis and death. Tetrodotoxin poisoning incubation period is very short, as short as 10-30 minutes, as long as 3-6 hours onset, the onset of acute, if the rescue is not timely, the fastest 10 minutes after poisoning death, the latest 4-6 hours death. Puffer fish poisoning is best to quickly send to the doctor, so as not to delay the diagnosis. p>In 1993, with the permission of the former Ministry of Health, the "National Collaborative Group on Safe Utilization of Puffer Fish" was set up to carry out research on the safety of consumption of cultured puffer fish, the results of which showed that the toxicity content of cultured puffer fish was significantly lower compared with that of wild puffer fish, and that the fish could be safely consumed after non-toxic processing. "The National Pufferfish Safety Utilization Collaborative Group has set up test sites for pufferfish in Qingdao, Dalian, Shenyang and other places to carry out research on the consumption of pufferfish on a trial basis, and after hundreds of thousands of cases of pufferfish being eaten on a trial basis, there has not been a single case of pufferfish poisoning. These preliminary research work has opened a solid foundation for the conditional opening of puffer fish.

In 2016, China's former Ministry of Agriculture issued the Circular on the Filing of Fish Source Bases for Cultured Puffer Fish, as well as the Circular on the Conditional Opening of Processing and Operation of Cultured Redfin Puffer and Cultured Darkfin Puffer, which was jointly issued by the former Ministry of Agriculture and the State Food and Drug Administration, and has since then formally included pufferfish in the conditional opening in China.

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