Prednisone acetate is also called prednisone, prednisone and dehydrocortisone.
Prednisolone acetate is also called prednisone, prednisolone and dehydrohydrocortisone. Their functions are basically the same. Prednisone must reduce the ll- keto group in the liver to ll- hydroxyl group and convert it into prednisolone prescription, which shows pharmacological activity, so it is not suitable for people with poor liver function. Prednisone and prednisolone are adrenocortical hormones. Mainly used for allergic and inflammatory diseases. Because the sodium retention effect of this product is weak, it is generally not used as an alternative treatment for adrenal cortical hypofunction. Both of these drugs are glucocorticoids and have great side effects, including:
(1) High-dose rapid intravenous administration may cause systemic allergic reactions, including swelling of face, nasal mucosa and eyelids, urticaria, shortness of breath, chest tightness and wheezing.
(2) Long-term medication can cause the following side effects: the face and posture, weight gain, edema of lower limbs, purple stripes, bleeding tendency, poor wound healing, acne, menstrual disorder, ischemic necrosis of humerus or femoral head, osteoporosis or fracture (including vertebral compression fracture and pathological fracture of long bone), muscle weakness, muscular atrophy, hypokalemia and gastrointestinal irritation (nausea and vomiting).
(3) Patients may have mental symptoms: euphoria, excitement, anxiety, delirium, disorientation or inhibition. People with chronic wasting diseases and people with mental disorders in the past are particularly prone to mental symptoms. When the dose reaches 40 mg or more of prednisone per day, it can appear in a few days to two weeks.
(4) Infection is the main adverse reaction of glucocorticoid. Fungi, tuberculosis, staphylococcus, Proteus, Pseudomonas aeruginosa and various herpes viruses are the main infections. Most of them occur in medium and long-term treatment, but they can also occur after short-term use of large doses.
(5) Hypothalamic-pituitary-adrenal axis inhibition is an important complication of hormone therapy, which is related to preparation, dosage, course of treatment and other factors. When the daily dosage of prednisone exceeds 20mg for more than 3 weeks, and iatrogenic Cushing's syndrome occurs, adrenal function should be considered to be inhibited.