Ganhuangcao was first seen in the Ming Dynasty's "Herbal Medicine for Saving Famine", which has the functions of clearing away heat and toxic materials, eliminating jaundice and removing dampness, promoting blood circulation and removing blood stasis, inducing diuresis and reducing swelling. It is the Miao people's experience in treating liver diseases and is called "immortal grass". At present, the Ganhuangcao area in Gulin County has been recognized and protected by the national geographical origin protection system. Modern research shows that penthorum chinense contains many effective components, which can protect the liver and reduce the damage of drinking and drugs to the liver.

According to the pathological analysis of liver fibrosis, there is a certain similarity between liver fibrosis and TCM syndrome accumulation. Similarly, Chinese medicine has a lot of knowledge about the pathogenesis of symptom accumulation, but in essence it is mainly blood stasis and phlegm turbidity. Liver cirrhosis is caused by qi deficiency and blood stasis, which leads to blood stasis, stagnation, blood coagulation and phlegm-dampness accumulation, and the blood collaterals are blocked and become lumps (hepatosplenomegaly), and then coagulate and harden and push away. According to the records in Tianbao Materia Medica and Jiuhuang Materia Medica, Hedyotis diffusa has the functions of dredging collaterals and promoting blood circulation, removing blood stasis and removing dampness, and promoting blood circulation and removing blood stasis. Effect on liver injury in experimental animals

1987 has carried out animal experiments on the pharmacological effects of dictyophora indusiata. Through carbon tetrachloride-induced liver injury model in rats and mice, it was found that 4.4g/kg Dictyophora dictyophora had the effect of reducing serum alanine aminotransferase in carbon tetrachloride-induced liver injury rats. It has protective effect on mice poisoned by carbon tetrachloride liver injury. It can reduce the retention of serum sodium bromosulfonate (BSP)20min mice with liver injury poisoning for 20 minutes and shorten the sleep time of pentobarbital sodium in mice with carbon tetrachloride poisoning, which indicates that Rabdosia root has a certain protective effect on carbon tetrachloride liver injury.

In the anti-hepatitis part, in the experiment of the protective effect of total saponins of sweet potato (PCPTS) on the increase of alanine aminotransferase (SGPT) in rats induced by carbon tetrachloride, the experimental results showed that compared with the control group, the SGPT in the carbon tetrachloride group increased by 65,438 0.33%, while that in the po and ip groups only increased by 68% and 56% respectively. Compared with the control group, intraperitoneal injection of carbon tetrachloride increased SGPT by 65438 020.8%, which indicated that intraperitoneal injection and intraperitoneal injection of high and medium doses of PCPTS (without deproteinization) could obviously resist the increase of SGPT in rats caused by carbon tetrachloride.

Laboratory study of hepatitis virus

In vivo antiviral effect, using Chongqing duck hepatitis B animal model, it was found that the serum DHBV DNA titer of Gansu duck in each dose group decreased significantly or extremely significantly (P < 0.05 or P

Antiviral effect in vitro: Chinese cabbage and its systematic extracts were applied to HBV DNA transfected cell line 22L5. When the water extract and direct water extract of cabbage reach a certain concentration, they have certain anti-hepatitis B virus effect in vitro. The results show that Gansu has certain anti-HBV activity in vitro, and its antiviral active components mainly exist in water extract and direct water extract. However, in the complex components of water extract and direct water extract, further separation, purification and research are needed to determine the effective monomers with anti-HBV activity.

Cholagogic and jaundice-relieving effects

When studying the effect of dictyophora on experimental liver injury, the acute cholagogic effect on rats was also studied. The results showed that Dictyophora dictyophora 4.4g/kg could significantly increase bile secretion 90min after duodenal administration (P

Reduce/neutralize the influence of alcoholic beverages

In 2006, the model of mice drunkenness caused by Wuliangchun was adopted. It was found that feeding Radix Curcumae and cauliflower before drinking can reduce the number of drunken mice and delay the time of drunkenness. Feeding turmeric and cabbage before drunkenness has no effect on liver function of mice. Feeding radish seeds can obviously delay the increase of serum ethanol concentration in mice, and the ethanol concentration in each dose group of radish seeds at each time point is lower than that in the control group, indicating that feeding radish seeds before drunkenness can eliminate the blood ethanol content of drunken mice. Compared with the control group, the duration of drunkenness in mice fed with root vegetables was slightly shorter. The ethanol concentration of Radix Curcumae and Radix Curcumae in each dose group was lower than that of the control group at each time point, indicating that feeding Radix Curcumae and Radix Curcumae after drunkenness can eliminate the ethanol content in the blood of drunken mice. Therefore, it is effective to give a certain dose of Rabdosia root to sober up mice. Yin also observed the disappearance of righting reflex in mice and analyzed the content of ethanol in blood, and studied the drunkenness time, tolerance time and the elimination of ethanol in blood of mice with different doses. The results showed that both before and after drinking, the high-dose group of mice could obviously delay the time of drunkenness, and the concentration of ethanol in blood of mice in each dose group showed a downward trend. It shows that root vegetables can prevent drunkenness and relieve alcoholism.

Antimutagenic effect

Cauliflower has protective effect on the increase of micronucleus rate in mice induced by cyclophosphamide. The results showed that both the high dose group of PCPTS and the low dose group of PCPTS had obvious antagonistic effects on the increase of micronucleus rate induced by Cy, and the antagonistic rates were 3 1.93%~44.77% and 57.60%~64.27% respectively. It shows that PCPTS has the function of anti-mutation, which can prevent the mutation of DNA in cells and prevent the occurrence of cancer in clinic. Penthorum chinense has the effect of relieving alcoholism and protecting liver. Gulin County, the hometown of liquor in China, has simple folk customs and everyone is good at drinking. However, the incidence of liver disease in this area is extremely low. Through the investigation, people ruled out the reasons such as water quality and wine storage mode, and finally focused on the custom of soaking water for generations by local people. Studies have shown that gallic acid and quercetin contained in penthorum chinense are known effective components with anti-HBV and liver protection effects. Long-term drinking is helpful to alleviate alcoholic liver injury.

External use can treat traumatic injury.