First, typical symptoms
1, asymptomatic period: only fluctuating or persistent hyperuricemia, but gout has not yet occurred. The time from the rise of serum uric acid to the appearance of symptoms can reach several years, and some can be asymptomatic for life.
2. Acute arthritis:
(1) Most patients have sudden onset at midnight or early morning, and the joint pain is severe, reaching the peak within a few hours, and the affected joints are red, swollen, hot, painful and dysfunctional.
(2) The first attack involved a single joint, especially the unilateral first metatarsophalangeal joint.
(3) The seizure was self-limited and relieved spontaneously within more than two weeks. After the redness subsided, the skin at the affected joints fell off.
(4) It may be accompanied by hyperuricemia, but the serum uric acid level is normal in some acute attacks.
(5) Uric acid salt crystals are found in joint fluid or tophi, which may be accompanied by fever.
Gout stone: Gout stone is a characteristic clinical manifestation of gout, which is typically located in auricle, but also around joints, olecranon, achilles tendon and patellar bursa. The appearance of tophi is uneven yellow-white vegetation with thin surface, and white powder or paste is discharged after crushing.
4. Manifestations of chronic arthritis: Chronic arthritis is more common in patients without standardized treatment, and the affected joints are asymmetrical, irregular swelling and pain. A large number of tophi are deposited in joints, which can cause joint bone destruction, lead to joint deformity, especially hands and feet, and can cause disability.
5. Symptoms of renal lesions: Gout patients with a long course of disease may have renal damage, and their symptoms are also very typical, which requires vigilance, including hematuria, dysuria and edema.
Second, other symptoms
In addition to the common joint-related symptoms, patients sometimes have other symptoms, including fever, increased heart rate, general malaise, chills and so on.