Uric acid in human body is mainly hyperuricemia caused by too much production or too little excretion. Generally, there are several reasons for the excessive production of uric acid, such as hyperuricemia with family inheritance, that is, people with a history of gout are prone to produce too much uric acid due to defects in enzyme metabolism. In addition, in some diseases, such as tumor, leukemia, myeloproliferative diseases, polycythemia and so on. Especially malignant tumor will obviously accelerate cell metabolism and increase the output of purine base to uric acid, so it will produce too much uric acid.

In addition, the reduction of uric acid excretion caused by some kidney diseases can also lead to hyperuricemia. For example, diseases such as glomerulonephritis and renal tubular injury will lead to decreased uric acid excretion, which will lead to increased uric acid.

Finally, the influence of drugs. Because many chemotherapy drugs or aspirin, diuretics and so on. It will lead to uric acid excretion disorder or excessive uric acid production, which will lead to hyperuricemia.