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Mechanism of lactulose oral solution in the treatment of constipation
1. After oral lactulose enters the colon, lactulose decomposing bacteria decompose lactulose into simple organic acids, which increases the acid content in the large intestine, especially in the proximal colon.

2. The increase of acidity and the growth of bacteria stimulate intestinal peristalsis, which shortens the passage time of food, reduces the retention time of stool in colon, and keeps it soft and shaped; Acidifying the intestinal environment, after lactulose treatment, the organic acids in the large intestine increase, which increases the osmotic concentration of intestinal contents, makes the stool retain water, increases the weight and volume of feces, effectively promotes intestinal peristalsis, and shortens the transit time of feces in the intestine. So that excrement can be discharged more smoothly.

3. It can induce diarrhea by forming osmotic gradient in intestinal cavity. As an osmotic laxative, lactulose is easy to be accepted by patients because of its good taste, and diabetic patients can also take this product. Lactulose solution has a certain stimulating effect on gastrointestinal tract because of its high concentration, which can be alleviated after being diluted with water.

4. Side effects. If there are different degrees of nausea after taking the medicine, the adverse reactions can disappear after diluting lactulose with the same amount of warm water for 1 time and taking it orally.

5. lactulose is converted into organic acid by the flora in the digestive tract in the colon, which leads to the decrease of pH value in the intestine, and increases the stool volume by retaining water, thus stimulating the peristalsis of the colon, keeping the stool unobstructed, relieving constipation and restoring the physiological rhythm of the colon.

6. The research shows that after mixed hemorrhoid surgery, the incidence of constipation in the observation group on the 3rd, 6th, 9th and 12th day after operation and the incidence of postoperative secondary incision edema caused by defecation are lower than those in the control group, suggesting that oral lactulose can significantly reduce the incidence of constipation and postoperative incision edema in patients with mixed hemorrhoids.

7. The application of lactulose after internal ligation and external excision of mixed hemorrhoids can promote the recovery of gastrointestinal function of patients after internal ligation and external excision of mixed hemorrhoids, effectively prevent constipation, reduce the incidence of early and late postoperative edema caused by forced defecation, and has no diarrhea side effects, which is safe and effective.