The swelling of lymph nodes in the neck is alert to nasopharyngeal cancer. 24-year-old Xiao Zhan, who was studying in the United States, was suspected of nasopharyngeal cancer due to the swelling of lymph nodes in his neck. Since there were very few local cases of nasopharyngeal cancer, he was advised to go back to his home country for treatment. Finally, Xiao Zhan was diagnosed with nasopharyngeal cancer by Prof. Xiao Jianyun from the Department of Otorhinolaryngology, Xiangya Hospital of Central South University. Dr. Tang Yaoyun of Department of Otorhinolaryngology, Xiangya Hospital, Central South University Prof. Xiao Jianyun said that swollen lymph nodes in the neck are very common. Some patients tend to see general surgery first, and after doing surgery and sending pathology slides, low-differentiated cancer cells are found, and only after searching for the primary lesion are found to be nasopharyngeal carcinoma. Therefore, for patients over 55 years old with enlarged lymph nodes in the neck, especially in the upper neck segment, it is important to check the nasopharynx, and to detect the possibility of nasopharyngeal carcinoma first through questioning and other examinations. Nasopharyngeal cancer is a kind of cancer with obvious racial difference, which occurs in yellow people and is rare in white people. NPC is a polygenic disease caused by a combination of viral, genetic and environmental factors. The incidence rate is higher in the southern region of China, such as Guangdong, Hunan, Jiangxi, Fujian and other provinces. In addition, nasopharyngeal cancer is often characterized by father-daughter, father-son and sister inheritance, all of which indicate that nasopharyngeal cancer has obvious familial and hereditary characteristics. For those who have enlarged lymph nodes in the neck and suspect nasopharyngeal cancer, the following screening should be done first: firstly, to look for the danger signals of nasopharyngeal cancer, such as nasal congestion, runny nose, blood; inability to hear, tinnitus, diplopia; headache, facial paralysis or pain, and so on. Second, nasopharyngeal indirect microscopy, which directly peeps into the nasopharyngeal cavity, is of great significance in diagnosing nasopharyngeal cancer and discovering early mucosal lesions. Third, nasopharyngeal fiberoptic examination. Nasopharyngeal fiberoptic mirror is soft and has the function of magnification, and it can directly bite the suspicious tissue for biopsy under direct vision. This examination method has been widely used in the screening of nasopharyngeal cancer and has gradually become a common method to diagnose nasopharyngeal diseases. Fourthly, EBV antibody test: EBV is closely related to nasopharyngeal cancer and it is a kind of virus that covers the whole population, more than 90% of children are positive, but it decreases with age in adults. Adults are mostly negative for EBV, but when nasopharyngeal cancer occurs, the titer of the virus may rise again and become positive, therefore, testing of EBV in adults can be used as a reference for diagnosis.The levels of antibodies against various antigens of EBV differ greatly between normal people and nasopharyngeal cancer patients, so regular monitoring of antibody levels and the trend of changes in the antibodies has a predictive role in the occurrence of nasopharyngeal cancer, and it is possible to detect very early nasopharyngeal cancer, and even find out some nasopharyngeal cancer without any clinical manifestations. It is possible to detect very early nasopharyngeal cancer, and even find some patients who do not have any clinical manifestations and do not have any abnormality under indirect microscopy. (Health News)