Nature and flavor: sweet; cold

Meridians: lung; stomach meridian

Efficacy: clearing away heat and detoxifying.

Indications: Fever due to febrile disease; dysentery due to heat poison and blood; carbuncle and furuncle; laryngeal paralysis and various infectious diseases

Selected prescription: Yinqiao Powder "Febrile Disease Treatise" ; Huizhuang Honeysuckle Powder "The Secret of Living Methods"; Yinhua Decoction "Zhulin Nvke";

Taboos: Do not take it if the spleen and stomach are deficient in coldness and those with qi deficiency, sores and clear pus. Pharmacological effects of honeysuckle Edit this section Return to table of contents Honeysuckle 1. Anti-pathogenic microorganism effect: In vitro experiments show that the flowers and vines are effective against a variety of pathogenic bacteria such as Staphylococcus aureus, hemolytic Streptococcus, Escherichia coli, Shigella dysenteriae, Vibrio cholerae, Typhoid bacilli and paratyphoid bacilli have certain inhibitory effects, and are also effective against pneumococci, meningococci, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The water infusion is stronger than the decoction, and the leaf decoction is stronger than the flower decoction. If combined with forsythia, the antibacterial range can be complementary; combined with penicillin, it can enhance the antibacterial effect of penicillin on drug-resistant Staphylococcus aureus, which may have a synergistic effect in inhibiting protein synthesis in bacteria. Some people think that chlorogenic acid and isochlorogenic acid are the main antibacterial active ingredients of honeysuckle. Other experiments have shown that luteolin also has strong antibacterial effects. This product's water immersion agent has varying degrees of inhibitory effects on skin fungi such as Microsporum rusty and Nocardia stariformis in vitro. Honeysuckle water decoction (1:20) has an inhibitory effect on influenza virus, orphan virus, and herpes virus in human embryonic kidney original monolayer epithelial cell tissue culture. The aqueous solution of rattan also has the effect of delaying the cell pathogenesis caused by orphan viruses. Test tube experiments show that decoctions of honeysuckle and its vine have inhibitory effects on Leptospira. The combination of Honeysuckle and Senecio can be used for intraperitoneal and subcutaneous injection. It is said to be effective in treating rabbits and preventing rhynchosis. Intraperitoneal injection of 7.5g/kg honeysuckle injection can make more than half of the mice that received LD90 Pseudomonas aeruginosa endotoxin or Pseudomonas aeruginosa survive. Intravenous injection of honeysuckle distillate 6g/kg has a therapeutic effect on rabbits poisoned by Pseudomonas aeruginosa endotoxin. The body temperature and total number of white blood cells of untreated animals decreased significantly, and the nuclei of white blood cells shifted to the left. However, the body temperature of animals in the drug group increased slightly. Although the white blood cells increased, the classification did not change significantly, and the intravenous injection of Jinhuang Injection (equal amount of honeysuckle and skullcap) Made) 7.5g/kg, it also has a certain antagonistic effect on Pseudomonas aeruginosa endotoxin poisoning in rabbits, and can reduce poisoning symptoms and deaths.

2. Anti-inflammatory and antipyretic effects: Intraperitoneal injection of 0.25g/kg honeysuckle extract can inhibit carrageenan-induced pedema in rats. It is also reported that honeysuckle injection 30-40g/kg can reduce the degree of egg white foot swelling. Intraperitoneal injection of honeysuckle extract 8g/kg, 2 times/day for 6 consecutive days, also has obvious anti-exudation and anti-proliferation effects on croton oily granulation cysts in rats. Early reports showed that honeysuckle has obvious antipyretic effect, but intravenous injection of cholera vaccine, potato bacilli, subtilis extract, etc. into rabbit ears can cause fever. It has not been confirmed that honeysuckle decoction 5g/kg orally administered has an antipyretic effect. It is considered that this It may be related to the honeysuckle preparation used, the dosage or the tolerance of rabbits.

3. Strengthen defense function: Honeysuckle decoction can still promote the phagocytosis function of white blood cells when diluted to a concentration of 1:1280. Intraperitoneal injection of honeysuckle injection into mice also significantly promoted the phagocytic function of inflammatory cells.

4. Central nervous system excitability: Various experimental methods such as electroshock and cage rotation have proven that oral administration of chlorogenic acid can cause excitement in the central nervous system of rats, mice and other animals. Its effect is as strong as that of coffee. Because of 1/6, there is no additive or reinforcing effect when the two are used together.

5. Hypolipidemia-lowering effect: Giving 2.5g/kg of honeysuckle to rats can reduce intestinal cholesterol absorption and reduce plasma cholesterol content. In vitro experiments also found that honeysuckle can combine with cholesterol, but Simiao Yong'an decoction (honeysuckle, scrophulariaceae, angelica, licorice) treated experimental atherosclerosis in rabbits. No effect on lowering blood lipids and aortic wall cholesterol levels was observed.

6. Anti-endotoxin: Use the Limulus test method to determine the endotoxin content. 300% honeysuckle (Lonicera japonica) injection is diluted 1:2-1:64. In vitro testing, whether using the concave plate method or the test tube method, All of them significantly reduced the endotoxin content in the test solution. The 1:2-1:8 dilution tube was in the same liquid state as the negative control tube, and the positive control was in gel form. Honeysuckle (Lonicera japonica) distillate 6g/kg is injected intravenously. It has an antagonizing effect on the decrease in body temperature and white blood cell count in rabbits caused by intravenous injection of 2.8mg/kg Pseudomonas aeruginosa endotoxin. Honeysuckle (Lonicera japonica) distillate 7.5g/kg or injection Intraperitoneal injection of 2.5g/kg solution has a protective effect on mice injected intraperitoneally with 65mg/kg Pseudomonas aeruginosa endotoxin and reduces mouse mortality.

7. Other effects: In vitro screening experiments have reported that water and wine extracts of honeysuckle have obvious cytotoxic effects on sarcoma 180 and Ehrlich ascites cancer. Oral administration of honeysuckle extract has a mild preventive effect on experimental gastric ulcer in rats. Oral administration of large doses of chlorogenic acid can increase gastrointestinal motility and promote gastric juice and bile secretion. Chlorogenic acid and its decomposition products have exciting effects on the isolated uterus of rats. In addition, chlorogenic acid can slightly enhance the pressor effects of epinephrine and norepinephrine in cats and rats, but has no effect on the nictitating membrane response in cats.

8. Pharmacology of processed products: Nanfang Sheng et al. used the coagulation time and in vitro antibacterial effect of mice as observation indicators to conduct experiments on honeysuckle products and baked products under different temperature and time conditions. Compare. The effect of its processing is affirmed, and it is initially believed that when honeysuckle is used to treat diseases such as dysentery and women's metrorrhagia, it is better to bake it at 200°C for 15 minutes or 220°C for 10 minutes. Sample preparation: Take 10 parts of honeysuckle and bake them in an electric oven at different temperatures and times. It is speculated that the content of chlorogenic acid, a known antibacterial component of honeysuckle, has decreased after heating and baking, but its antibacterial effect has not been correspondingly reduced. On the contrary, the antibacterial effect of Shigella dysenteriae and Proteus has been enhanced, indicating that green Original acid is not its only antibacterial component. As for whether new antibacterial components are generated after honeysuckle is roasted, further research is needed.