Catalog 1 Pinyin 2 English Reference 3 National Essential Drugs 4 Ma Ren Lun Bowel Pill Pharmacopoeia Standard 4.1 Name 4.2 Prescription 4.3 Method of Preparation 4.4 Characteristics 4.5 Identification 4.6 Inspection 4.7 Content Determination 4.7.1 Chromatographic Conditions and System Suitability Tests 4.7.2 Preparation of Control Solution 4.7.3 Preparation of Supplemental Solution 4.7.4 Assay 4.8 Functions and Indications 4.9 Usage and Dosage 4.10 Notes 4.11 Specifications 4.12 Storage 4.13 Version 5 The Ministry of Chinese Medicine Standard 5.1 Pinyin 5.2 Standard No. 5.3 Edition 5 Ma Ren Lun Bowel Pills 4.9 Functions and Indications 4.10 Precautions 4.11 Specifications 4.12 Storage 4.13 Version 5 Ma Ren Lun Bowel Pill Chinese Medicines Standards 5.1 Pinyin 5.2 Standard No. 5.3 Prescription 5.4 Method of Preparation 5.5 Characteristics 5.6 Identification 5.7 Inspection 5.8 Functions and Indications 5.9 Functions and Indications 5.10 Precautions 5.11 Specifications 5.12 Storage 6 Instruction of Ma Ren Lun Bowel Pill 6.1 Name of the Medicine 6.2 Hanyu Pinyin 6.8 Functions and Indications 6.9 Dosage 4.10 Precautions 5.11 Specifications 5.12 Storage 6.2 Pinyin 6.3 Formulations 6.4 Properties 6.5 Main ingredients of Ma Ren R&E Pill 6.6 Pharmacological effects of Ma Ren R&E Pill 6.7 Functions and main indications of Ma Ren R&E Pill 6.8 Usage and dosage of Ma Ren R&E Pill 6.9 Precautions 6.10 Expert's comments Attachment: * Other versions of instructions for Ma Ren R&E Pill 1 Pinyin

má rén rùn cháng wán

2 English reference

Má rén cháng wán

2 English Reference

Maren Runchang Wan

3 National Essential Drugs

National Essential Drugs Retail Price Information for Maren Runchang Wan

Serial No. Essential Drugs

Catalog No. Name of Drug Formulations Specification Units Retail Price

Guiding Price Category Remarks 72 10 Maren Runchang Wan, Honey Pill, 6g Pill 0.67 Proprietary Chinese Medicines *

Note:

1. The dosage form specifications marked with "*" in the Remarks column of the table are representative products.

2. The dosage form specifications marked with "△" in the Remarks column of the table, as well as other specifications of the same dosage form, are the temporary prices.

3. For dosage form specifications with dosage indicated in the Remarks column, the prices of other specifications in the dosage form are calculated based on the same dosage and in accordance with the "Rules on Pharmaceutical Differential Prices".

4. The "honey pill" labeled in the dosage form column of the table includes small honey pills and large honey pills.

4 Maren Runchang Wan Pharmacopoeia standard 4.1 Name

Maren Runchang Wan

Maren Runchang Wan

4.2 Prescription

120g of flaxseed, 60g of fried bitter almonds, 120g of rhubarb, 60g of wood, 120g of tangerine, 60g of white peony

4.3 Preparation

The above six flavors, pulverized into a fine powder, sieve, mix. Mix well. Each 100g of powder with 140-160g of honey to make large honey pills, that is.

4.4 Properties

This product is yellow-brown honey pill; gas slightly fragrant, bitter taste, slightly sweet.

4.5 Identification

(1) Take this product, placed under the microscope: calcium oxalate cluster crystals large, diameter 60-140μm (rhubarb). Calcium oxalate square crystals exist in thin-walled cells in sheets (Chen Pi). Calcium oxalate clusters with a diameter of 18-32 μm, exist in thin-walled cells, often arranged in rows, or a cell containing several clusters (Paeonia lactiflora).

(2) take 4g of this product, cut, add methanol 15ml, grinding to dissolve, ultrasonic treatment for 10 minutes, filtration, filtrate evaporation, residue with 2ml of methanol, divided into 2 times, gently shaking for 10 seconds, divided into the supernatant, as a test solution. Also take 0.3g of rhubarb control herb, 0.2g of Mucuna pruriens control herb and 0.2g of flaxseed control herb, respectively, add 3ml of methanol, ultrasonic treatment for 10 minutes, the supernatant was used as the control herb solution. According to the thin-layer chromatography (2010 version of Pharmacopoeia, Appendix VI B), absorb the above four solutions of 3-6μl, respectively, on the same silica gel GF254 thin layer plate, with cyclohexane - ethyl acetate formic acid (12:2:0.2) as the unfolding agent, unfolding, remove, drying, and placed in the ultraviolet light (365nm) under the examination. In the chromatogram of the test material, in the corresponding position with the chromatogram of rhubarb control herbs, fluorescent spots of the same color were shown; sprayed with 5% vanillin sulfuric acid solution-ethanol (1:6) mixture, and blown with hot air until blue spots were shown in the chromatogram of Mucuna pruriens control herbs, and in the chromatogram of the test material, in the corresponding position with the chromatogram of Mucuna pruriens control herbs, spots of the same color were shown; and then continued to Heat until all the spots are presented, the test chromatogram, in the corresponding position with the control herbal chromatogram of flaxseed, show at least three spots of the same color.

(3) Take 0.25g of Chenpi control herb, add 3ml of methanol, ultrasonic treatment for 10 minutes, the supernatant is used as the control herb solution. According to the thin-layer chromatography (2010 version of the Pharmacopoeia, a Appendix VI B) test, absorb the above control herb solution and [identification] (2) under the test solution of 4 ~ 6 μl, respectively, were spotted on the same silica gel G thin-layer plate, with cyclohexane - ethyl acetate - formic acid (5.5: 4.5; 0.1) as the unfolding agent, unfolding, remove, drying, placed in a UV light, and then remove from the plate. Remove, dry and examine under UV light (365 nm). In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the fluorescent spots of the same color.

(4) Take 0.25g of the control herb of Paeonia lactiflora, add 3ml of methanol, ultrasonic treatment for 10 minutes, the supernatant as the control herb solution. According to the thin-layer chromatography (2010 version of the Pharmacopoeia, a Appendix VI B) test, absorb the above control herb solution and [identification] (2) under the test solution of 4 ~ 6μl, respectively, were spotted on the same silica gel G thin-layer plate, with trichloromethane - ethyl acetate - methanol - concentrated ammonia solution (8: 1: 4: 1) as the expansion agent. : 4:1) as the unfolding agent, unfold, remove, dry, spray with a mixture of 5% vanillin sulfate solution-ethanol (1:6), and heat at 105℃ until the spots showed clear color. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the main spot of the same color.

4.6 Inspection

It should comply with the relevant provisions under pills (2010 version of Pharmacopoeia I Appendix I A).

4.7 Determination of content

Determined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI D).

4.7.1 Chromatographic conditions and system suitability test

Octadecylsilane-bonded silica gel as filler; acetonitrile-methanol-0.1% phosphoric acid solution (42:23:35) as the mobile phase; detection wavelength of 254 nm; the theoretical plate count should be not less than 3000 according to the peak of rhubarb phenol.

4.7.2 Comparison with the control solution

The chromatographic conditions were as follows 4.7.2 Preparation of control solution

Take rhubarb phenol control and rhubarb pigment control, weigh precisely, add methanol to make a mixed solution containing 10 μg of rhubarb phenol and 5 μg of rhubarb pigment per 1 ml, that is, obtained.

4.7.3 Preparation of test solution

(1) take the product under the weight difference, cut, mix, take 1g, precision weighing, placed in a stoppered conical flask, precision add methanol - hydrochloric acid (10: 1) of the mixed solution of 25 ml, weighing, immersed in more than 10 hours, ultrasonic treatment so that the dissolution of the 80 ℃ water bath heated reflux 30 minutes, if the wall of the bottle has adhered to the bottle. Minutes, if the wall of the bottle has adherents, must be ultrasonic treatment to remove, and then weighing, with methanol to make up for the loss of weight, shaking, filtration, precision aspirate 2ml of filtrate, placed in a 5ml measuring flask, add 2% of sodium hydroxide solution 1ml, add methanol to the scale, shaking, filtration, filtrate, take the filtrate, used for the determination of the total rhubarb phenol and total rhubarb pigment content.

(2) Take 1g of the above cut sample, weigh it precisely, put it in a stoppered conical flask, add 25ml of methanol precisely, weigh it, soak it for more than 10 hours, grind it with a glass rod to make the sample dissolve, rinse the glass rod with several drops of methanol in the conical flask, ultrasonicate it (160W, 50kHz) for 30 minutes, let it cool down, then weigh it again, and make up for the lost weight with methanol, or dissipate it to the original weight, shake it. Or volatile to the original weight, shake well, filtered, take the filtrate, for the determination of free rhubarb phenol and free rhubarb pigment content.

4.7.4 Determination method

Precisely suck up the control solution and the above two kinds of test solution each 10-20μl, injected into the liquid chromatograph, measurement, calculation of the total amount of total rhubarb phenol and total rhubarb pigment and the total amount of free rhubarb phenol and free rhubarb pigment; with the total amount of total rhubarb phenol and total rhubarb pigment and the total amount of free rhubarb phenol and free rhubarb pigment, as the total amount of anthraquinone combined with the total amount of rhubarb phenol and rhubarb pigment, that is, the total amount of anthraquinone combined with the total amount of anthraquinone. rhubarb phenol and free rhubarb pigment in bound anthraquinone, the total amount is obtained.

Each pill of this product contains rhubarb in terms of the total amount of total rhubarb phenol (C15H10O4) and total rhubarb pigment (C15H10O5), shall not be less than 4.0mg; in terms of the total amount of rhubarb phenol (C15H10O4) and rhubarb pigment (C15H10O5) combined with anthraquinone, shall not be less than 2.0mg.

4.8 Functions and Indications

To lubricate the intestines and pass the bowel. Used for the accumulation of heat in the stomach and intestines, chest and abdominal distension, constipation.

4.9 Dosage and administration

Oral. 1 to 2 pills at a time, twice a day.

4.10 Caution

Not to be taken by pregnant women.

4.11 Specifications

Each pill weighs 6g

4.12 Storage

Sealed.

4.13 Version

Chinese Pharmacopoeia 2010 Edition

5 Maren Runchang Wan 5.1 Pinyin

Maren Runchang Wan

5.2 Standard No.

WS3B143893

5.3 Prescription

Maren Runchang Wan 120g Bitter Almonds (Peeled and Stir-fried) 60g Rhubarb 120g Auckland 60g Pericarpium Citri Reticulatae 120g Aucklandia Lappa 120g Pericarpium Citri Reticulatae 60g Pericarpium Citri Reticulatae 120g Lappa Lappa 60g Pericarpium Citri Reticulatae 120g Radix Paeoniae Alba 60g

5.4 Method of Preparation

The above six flavors, pulverized into fine powder, sifted, mixed well, and for every 100g of powder, add 140~160g of condensed milk to make big honey pills, that is, it is obtained.

5.5 Properties

This product is yellow-brown honey pill; gas slightly fragrant, bitter taste, slightly sweet.

5.6 Identification

(1) Take this product and observe under the microscope: calcium oxalate clusters are large, with a diameter of 60-140 μm; calcium oxalate square crystals exist in thin-walled cells in sheets. Calcium oxalate clusters with a diameter of 18-32 μm, exist in thin-walled cells, often arranged in rows, or a cell containing several clusters.

(2) Take 6g of this product, add 6g of diatomaceous earth, study, add 50ml of methanol reflux extraction for 30 minutes, filtration, filtrate evaporation, residue with 20ml of water to dissolve, then add 1ml of hydrochloric acid, placed on a water bath and heated for 30 minutes, cooled, and then shaken with ether for 2 times, 20ml each time, combined with the ether solution, evaporate and dry, the residue with ethyl acetate 1ml to make soluble as a solution for the test product. Add 1ml of ethyl acetate to dissolve the residue as the test solution. Take 0.5g of Rheum palmatum control herb, add 20ml of methanol to make control herb solution in the same method. According to thin-layer chromatography (Appendix VI B), take 1￣2μl of each of the above two solutions, and put them on the same silica gel H thin-layer plate with sodium carboxymethylcellulose as binder, and use the upper solution of petroleum ether (30￣60℃), ethyl formate and formic acid (15:5:1) as the unfolding agent, unfold it, take it out, dry it, and put it in ultraviolet light (365 nm) to check, the color chromatogram of the test product shows the same color chromatogram as that of control herbal material. In the chromatogram of the test material, in the corresponding position with the control material, the same five orange fluorescent spots, put ammonia vapor fumigation, the spots become red.

5.7 Inspection

Should comply with the provisions under the pill (Appendix I A).

5.8 Functions and Indications

To moisten the intestines and pass stool. Used for the accumulation of heat in the stomach and intestines, chest and abdominal distension, constipation.

5.9 Methods of use and dosage

Oral, one to two pills, twice a day.

5.10 Caution

Not to be taken by pregnant women.

5.11 Specifications

6g per pill

5.12 Storage

sealed.

6 Ma Ren Runchang Wan 6.1 Name

Ma Ren Runchang Wan

6.2 Pinyin

Maren Runchang Wan

6.3 Formulation

6g per pill.

6.4 Character

Ma Ren Runchang Wan is a yellowish-brown color honey pill; it has a slightly fragrant smell, bitter taste and slightly sweet taste.

6.5 The main ingredients of Ma Ren Lun Bowel Pills

Hemp kernel, fried bitter almonds, rhubarb, wood, Chen Pi, white peony

6.6 Pharmacological effects of Ma Ren Lun Bowel Pills

1. Hemp kernel, rhubarb, Chen Pi can enhance intestinal peristalsis.

2. Antibacterial and antipyretic: rhubarb and Paeonia lactiflora have antibacterial and antipyretic effects.

6.7 Functions and Indications of Hemp Ren Run Intestine Pill

To moisten the intestines and pass stool. Used for the accumulation of heat in the intestines and stomach, chest and abdominal distension, constipation. Used for the treatment of habitual constipation, maternal constipation, constipation of the elderly intestinal dryness, hemorrhoidal constipation of gastrointestinal heat, with chest and abdominal distension, urination can be effective. Treatment of bleeding hemorrhoids is the intestines and stomach dry heat is also effective.

6.8 Usage and dosage of Ma Ren Run Intestine Pill

Oral. One to two pills, twice a day.

6.9 Precautions

Not to be taken by pregnant women.

6.10 Expert Comment