Perennial herb of Lobelia of Campanulaceae. The stems are slender, creeping, rooting at nodes and erect branches. Leaves alternate, sessile or subsessile, elliptic-lanceolate to strip. Flowers usually 1 flower, bearing branched upper leaf axils; Pedicel thin, bracteoles glabrous; Calyx tube obconical; Corolla pink or white. Capsule obconical, about 6 mm long. Seeds elliptic, slightly compressed, nearly flesh-colored. Flowering and fruiting period may 5- 10/0 month.
Distributed in the middle and lower reaches of the Yangtze River in China and the southern provinces; It is also distributed in other Asian countries east of India.
Extended data:
1, diuretic effect: Lobelia chinensis extract iv in anesthetized dogs or Lobelia chinensis total alkaloid 6.6mg/kg, normal rats ig 1g/kg, and normal people po Lobelia chinensis powder 10-30g all have significant and lasting diuretic effect. Inulin isolated from Lobelia chinensis can inhibit diuresis if it is given to rats with po or ip.
2. Effect on nervous system: The effect of Lobeliane on nervous system is similar to that of nicotine, but its intensity is only 1/5- 1/20 of that of nicotine, and it can excite the plant ganglion, adrenal medulla, medulla oblongata (especially vomiting center), neuromuscular junction, and chemoreceptors of carotid body and aortic body at first and then inhibit them.
3. Inhibitory effect on the central nervous system: The succinic acid contained in this product can protect animals against hyperbaric oxygen, electric shock and audiogenic convulsion by ip administration to mice, rats, guinea pigs, rabbits, cats and dogs. Hot plate method has analgesic effect, synergistic effect with pentobarbital sodium, calming and lowering body temperature.
4. Respiratory excitation: Lobelia chinensis decoction and its alkaloid preparation iv have significant respiratory excitation on anesthetized dogs. Its effect is strengthened and prolonged with the increase of dose. When the dose is too large, it can cause respiratory paralysis and death. After resection of sinus nerve or carotid body and injection of Lobelia chinensis preparation, there is no obvious respiratory excitement.
It shows that its mechanism of action is mainly to stimulate the chemoreceptor of carotid body and excite the respiratory center reflexively. Lobeliane has a good excitatory effect on morphine-induced respiratory depression, but it is worse for those caused by urethane and chloral hydrate. Lobeliane inhalation can dilate bronchi and resist tracheal contraction caused by pilocarpine and acetylcholine.
5. Effect on cardiovascular system: Lobelia chinensis extract iv has a significant and lasting antihypertensive effect on anesthetized dogs. For example, the dosage of 10-20 times that of intravenous administration is needed to be effective. It has also been reported that a small amount of iv decoction has a short-term pressor effect, while a large amount has a longer-lasting hypotensive effect.
Lobelia chinensis alkaloids have an exciting effect on isolated rabbit hearts and frog hearts, which strengthens the contractility and increases the amplitude. At high concentration, temporary excitement occurs, followed by inhibition, and finally conduction block and cardiac arrest occur. Lobeliane im, while breathing excited, slows down the heart rate and increases blood pressure; At high dose, the heart rate increases, the blood pressure drops obviously, and finally the heart is paralyzed.
6. Bile-promoting effect: Bile flow of dog iv Lobelia chinensis decoction and alcohol precipitation preparation 1g (crude drug) /kg increased by more than 2 times compared with that before administration, and reached the peak after 50 minutes of administration, but the concentrations of solid, cholate and bilirubin in bile decreased.
7. Anti-snake venom effect: Lobelia chinensis preparation, and sodium succinate, sodium fumarate and sodium p-hydroxybenzoate separated from it were po 30 minutes before snake venom injection.
Or injecting snake venom with sc drugs, or using sodium succinate, sodium fumarate and sodium acetate to form a compound 30 minutes-4 hours before injecting snake venom, all of them have a high protection effect on mice injected with the minimum lethal dose of cobra venom, with the protection rate of 59. 1-93. 1%. However, if it is administered 25 minutes after the injection of snake venom, it has no protective effect.
Baidu encyclopedia-lobelia chinensis
Traditional Chinese Medicine Family-Lobelia chinensis