Abdominal pain or even colic often occurs in patients with kidney stones, the so-called 10-minute rapid pain relief is generally achieved through oral or intravenous infusion of pain relieving and antispasmodic drugs, such as intramuscular injection of 654-2 and prednisolone, and those with smaller stones may choose to medication lithotripsy. However, because of the individual's constitution, condition, and sensitivity to medication, the time it takes for the medication to take effect and the therapeutic effect of the medication varies from person to person.

Often patients with painful kidney stones are commonly used diclofenac sodium, indomethacin, aspirin and other non-steroidal anti-inflammatory analgesics, as well as morphine, pethidine, buproprion, tramadol, and other opioid analgesics, combined with antispasmodic drugs such as atropine, scopolamine, and other spasmodic drugs, diastolic ureteral smooth muscle, antispasmodic and analgesic. Currently alpha 1 receptor blockers are also used to relieve the symptoms of renal colic caused by ureteral spasm.

For patients with smaller stones and milder symptoms, medications such as diclofenac sodium, tamsulosin, sodium hydrogen potassium citrate, sodium bicarbonate, and allopurinol can be tried to remove stones. However, only a small number of patients are applicable, and most patients need to undergo extracorporeal shock wave lithotripsy, nephrolithotripsy, ureteroscopy lithotripsy and other ways to remove the stones.

Additionally, acupuncture can be used as an adjunctive treatment, but it needs to be done under the guidance of a professional Chinese medicine doctor. Most of the patients can get a good prognosis after active treatment, but also need to cooperate with drinking more water, as well as avoiding diets containing oxalic acid, such as strong tea, spinach, asparagus, nuts, etc., and higher purine diet, such as animal offal, beef and lamb, sea fish, etc., according to the doctor's guidance for a reasonable diet.