No. Toxicity Type Test Method Test Object Dose Used Toxic Effects 1 Acute Toxicity Oral Rat 2220 mg/kg 1. Behavioral Toxicity - lethargy 2. Gastrointestinal Toxicity - hypermotility, diarrhea 2 Acute Toxicity Oral Mouse 2225 mg/kg 1. Behavioral toxicity - Convulsions or seizure thresholds are affected 2. Behavioral toxicity - ****济失调 3. Pulmonary, thoracic, or respiratory toxicity - -Irritation of the respiratory tract 3 Acute toxicity Intraperitoneal Mouse 200 mg/kg Detailed effects not reported for values other than lethal dose 4 Acute toxicity Intravenous Mouse 75 mg/kg Detailed effects not reported for values other than lethal dose 5 Acute toxicity Parenteral Mouse 200 mg/kg Detailed effects not reported for values other than lethal dose 6 Acute toxicity Oral guinea pig 1160 mg/kg 1. Behavioral toxicity - coma 7 Chronic toxicity Oral rat 35 mg/kg/24W-C 1. Hepatotoxicity - change in liver weight 2. Biochemical toxicity - -Inhibition or induction of hepatic microsomal mixed-function oxidases (dealkylation, hydroxylation, etc.) 3.Chronic disease-related toxicity - Death 8 Chronic toxicity Oral rat 8092 mg/kg/17W-I 1. - Decreased liver function 9 Ocular toxicity Skin surface Humans 40 mg/48H Severe effects 10 Mutagenicity Salmonella typhimurium 500 ug/plate11 Mutagenicity Bacillus subtilis 10480 ug/disc12 Mutagenicity Extra-intestinal Drosophila 2 pph13 Mutagenicity Mouse leukocytes 31500 ug/L14 Mutagenicity Mouse leukocytes 31500 ug/L15 Mutagenic hamster embryos 50 umol/L16 Mutagenic hamster fibroblasts 15 mg/L17 Reproductive toxicity Oral Rat 55 mg/kg, females 7-17 days after conception 1. Reproductive toxicity - Abnormalities in cranial and facial development (including nose/tongue) 18 Reproductive toxicity Oral rat 275 mg/kg, 7-17 days after female conception 1.Reproductive toxicity - abnormal musculoskeletal system development Toxicity

References: