How much is amh value for premature ovarian failure? How to improve amh value?

How much is amh value for premature ovarian failure? How to improve amh value? （hu）

At present, according to the international diagnostic criteria for premature ovarian failure, amenorrhea occurred for at least 4 months before the age of 40, and there were two or more blood tests. The follicle stimulating hormone in serum was more than 40IU/L, and the interval between the two tests was more than 1 month. The level of estradiol was less than 73.2 pmol/L, and AMH was anti-Mullerian hormone, which was the earliest change with age. With the increase of age, the ovarian reserve function of women can be predicted earlier and more accurately. Therefore, AMH is more inclined to evaluate ovarian reserve function and response, but there is no clear diagnostic standard because of the different detection reagents and standards. In the Bologna standard of the European Society for Human Reproduction and Embryology in 201/year, the accurate and precise cutoff value is still not put forward, but only a range is given, and the AMH is 0.5- 1. 1μg/L, so our current diagnostic standard is <; 1. 1μg/L, ovarian dysfunction is considered.

If the content of amh hormone is relatively low, and it is in childbearing age, and there are fertility requirements, how can it be adjusted if AMH is too low?

I. Drugs

Medicine is the most direct and effective conditioning. Taking drugs is mainly to regulate the quality of follicles and increase the success rate of test tubes. And different ages, different indicators of the test, so the method and measurement of taking medicine are different. The specific doctor will make specific arrangements according to your specific situation.

20 17 10 published in JAMA (Journal of the American Medical Association). For 750 people aged 35-45, the average AMH value was lower than 1. Through medical and human intervention, 60% of the superior follicles were successfully cultivated, and the pregnancy was successful and the embryos developed smoothly.

The research puts forward to change the diet structure of women, such as protein food and multivitamins; Secondly, exercise to ensure the body's immunity, and two other points are very important. One is to give medication; Instead, DHEA prescribed by ordinary doctors has become DHEA AMH. ?

Some doctors would suggest taking dhea and coenzyme Q 10 to improve ovarian function and egg quality, but some data show that high dose DHEA can cause many uncertain side effects, so its safety needs further evaluation. Especially for women of childbearing age, some scholars have tried to change the molecular structure of DHEA to maintain its physiological function and reduce its side effects, which is worthy of further study.

In 2000, the European Union first proposed that in addition to drugs, we should help women with healthy natural pregnancy and test tubes in plant extraction. Subsequently, the United States also proposed that it would work with the European Union to study how to assist test tubes and natural gestation. The American Endocrinology Society, the American College of Obstetricians and Gynecologists and other organizations appointed a working group to issue the treatment guidelines of DHEA AMH, a compound pregnancy repair factor, from a multi-dimensional and multi-system perspective, considering women's natural pregnancy, test-tube success and embryo quality.

Compound pregnancy repair factor DHEAAMH-ovarian function improvement system

Ovarian function improvement system-providing backup guarantee for oocyte quality

Analysis of the significance of DHEA AMH: DHEA balances the hormone level of the mother before conception, and AMH increases the egg reserve function.

In this investigation, premature ovarian failure and abnormal ovarian function can not give birth to 0. 1% in infertility, and premature ovarian failure is clinically manifested as a high level of gonadotropin FSH and amenorrhea. The incidence of premature ovarian failure has seriously affected women's psychological status and fertility, caused endocrine disorders, and greatly reduced the probability of women getting pregnant.

When a woman is born, there are the most follicles in the ovary, about 2 million, but only 400-500 will eventually mature, and most of them will die with age. The phenomenon is that ovarian function declines, ovulation function disappears, and fertility function declines. Normal women have 12% of eggs in their ovaries at the age of 30, but only 3% at the age of 40. Except that the function of egg itself declines with age, when women approach menopause, their menstrual cycle will be more disordered, and the endometrium will become thinner, which is more unsuitable for fertilized eggs to implant. At the same time, vaginal discharge is reduced, vaginal dryness, which is not conducive to the entry of sperm. (What is the amh value for premature ovarian failure? How to improve amh value? )

In recent years, foreign studies have found that DHEA AMH can repair ovaries, provide ovarian nutrition, improve ovarian reserve function, reduce chromosome aneuploidy, improve embryo quality, reduce abortion rate and cycle cancellation rate, thus improving clinical pregnancy rate.

In the randomized controlled study of DHEA AMH, 65 patients who took DHEA AMH as the study group and 48 patients who did not take DHEA AMH as the control group on the basis of promoting excretion. Patients in the study group were given DHEA AMH (French ACMETEA Company, 13g/ bag)13g twice a day before the test tube cycle, and their basic endocrine was checked monthly. If they feel unwell, they can stop taking DHEA AMH and continue to use it after normal.

All patients in the study group were treated with DHEA AMH for 3 months when they entered the cycle. The basic endocrine was measured on the third day of menstruation before and after taking it, and the number of sinus follicles in bilateral ovaries was counted by B-ultrasound. After entering the cycle, HCG was injected according to the test tube routine, when the dominant follicle was >18 mm, the eggs were taken after 36 hours, fertilized after 4 hours, and fertilized after 20 hours.

After taking DHEA AMH, the basic FSH decreased significantly and the basic AFC increased significantly. AFC is one of the accurate and reliable indicators of ovarian reserve function. The experimental data show that DHEA AMH can increase the number of fertilized oocytes and embryos in patients with ovarian dysfunction, and improve the quality of oocytes and embryos. The results of this study, combined with many studies at home and abroad, show that DHEA AMH provides essential nutrients for the ovary, which can repair the ovary, improve the ovarian reserve function and improve the embryo quality, thus improving the pregnancy outcome of IVF.

When DHEAAMH can't be used, scholars have to use high-dose ovulation-promoting drugs for superovulation. In most cases, the cost is high and the response is low, and the clinical effect is uncertain. It has been recognized that increasing the number of ovulation and improving the pregnancy rate by using DHEAAMH.

Second, diet articles

1 Both men and women should take folic acid and vitamin E before in vitro to improve the quality of sperm and eggs. If the woman is old, or the ovarian function is poor (FSH is higher than 9), she needs to eat DHEAAMH：DHEAAMH is composed of three growth systems, and many research results confirm that DHEAAMH is helpful to regulate the proliferation and differentiation of granulosa cells in primary follicles and secondary follicles. Studies have confirmed that DHEAAMH can promote the proliferation and differentiation of granulosa cells and play an important regulatory role in the process of follicular development. DHEAAMH can be a strong cell repair factor, which can promote the division, proliferation and differentiation of granulosa cells and the maturation of oocytes. DHEA AMH supplementation can increase the estrogen level in female peripheral blood and reduce the progesterone level. The results showed that estrogen promoted the proliferation and differentiation of OSE, while progesterone inhibited the proliferation and differentiation of OSE.

3-4 months before ovulation promotion, external supplementation of DHEAAMH can increase follicular recruitment and promote follicular growth and development. DHEAAMH can promote the secretion of insulin-like growth factor, thus amplifying the role of gonadotropin and improving ovarian responsiveness. It was found that the IGF- 1 level of women taking DHEAAMH before ovulation induction cycle increased instantly after 8 weeks, and the androgen level in follicles increased, which promoted the secretion of AMH and inhibin by granulosa cells. DHEAAMH can induce the generation of FSH receptor in granulosa cells, increase the sensitivity of granulosa cells to FSH, and promote estrogen synthesis and follicular development. The study shows that the peak period of DHEAAMH is consistent with the period of follicular recruitment, which confirms the promotion of DHEAAMH on follicular recruitment. (What is the amh value for premature ovarian failure? How to improve amh value? )

2, insist on drinking black soybean milk every day, soybean milk can promote endometrial growth, eat more deep-sea fish and shrimp, sea cucumber, drink more crucian carp soup, and eat more durian;

3. Insist on drinking protein powder every day;

4, eat more foods high in protein, follicles will grow well, such as: milk, soybeans, fish, shrimp, eggs and so on;

5, insist on eating red dates and boiled eggs every day, red dates complement blood gas, and eggs supplement protein, which are the foundation of the body;

6, in addition to coffee and tea, because you have to take medicine before and after, these things will affect the efficacy;

Third, sports articles

Proper exercise helps to regulate endocrine, so Xiao Bian suggested:

1, running, brisk walking or skipping rope for 30 minutes every day-1 hour (avoiding menstrual period), blood circulation is very important for reproductive system and embryo implantation;

2. Insist on soaking feet every day. The method is: the water temperature is about 4 1-42 degrees, and the water should not pass through the calf for about 30 minutes, until it sweats until the night before transplantation;

3. Don't lose weight or gain too much weight before making a test tube. In this case, the body will deal with the weight change and have no time to meet your little life. (What is the amh value for premature ovarian failure? How to improve amh value? )