bá 3.12 Dosage and Administration of Total Glucosides of Paeony 3.13 Interaction between Total Glucosides of Paeony and other drugs 3.14 Expert Review 3.15 Attachment: * Other versions of the drug list of Total Glucosides of Paeony 1 Pinyin
bái sháo zǒng gān
2 English referenceTotal Glucosides of Paeony [Xiangya Medical Dictionary]
3 Total Glucosides of Paeony Instruction 3.1 Drug NameTotal Glucosides of Paeony
3.2 English NameTotal Glucosides of Paeony
3.3 Alias of Total Glucosides of PaeonyPavulin
3.4 Classification
Nervous System Drugs > Antipyretic & Analgesic Drugs > Others
3.5 Dosage formEach capsule
3.6 Pharmacological effects of Paeonia lactiflora(1) Antispasmodic effect: Paeonia lactiflora glucoside and high concentration of paeoniflora decoction has antispasmodic effect on guinea pigs, rats, isolated intestinal tubes, gastric and uterine smooth muscle are inhibitory, and can antagonize oxytocin-induced contraction, licorice methanol extract Fm100 and paeonia lactiflora glucoside has a synergistic effect, the clinic with "" pain and diarrhea essential formula "" on the pain and diarrhea, the pain and diarrhea of the blood. Pain and diarrhea formula" has good effect on abdominal pain, all indicate that the total paeoniflorin has the effect of relieving smooth muscle spasm. (2) Antiplatelet agglutination and thrombosis: the extract of Paeonia lactiflora was tested by in vitro simulated circulation test, and the rate of thrombosis was low. Platelet agglutination test with Paeonia lactiflora showed that Paeonia lactiflora has the effect of counteracting ADP-induced platelet aggregation and counteracting the aggregation of platelets by arachidonic acid, and the active ingredients are d-catechin and ethyl gallate in Paeonia lactiflora. (3) Effects on cardiovascular system: Paeonia lactiflora extract has obvious effects on cardiac hemodynamics of anesthetized dogs, slowing down the heart rate, lowering the blood pressure, reducing the burden on the heart, and these effects are conducive to the recovery of pathological cardiac function, Paeonia lactiflora extract can prolong the survival time of normobaric and low-pressure oxygen deprivation of mice, and it can counteract the increase in myocardial oxygen consumption of the animals caused by isoproterenol adrenal glandular adenosine, and it can enhance the flow of the guinea pig isolated heart and coronary artery. coronary flow; and against norepinephrine. Adrenaline-induced contraction of the isolated aorta of rabbits has an obvious antagonistic effect; can counteract the rabbit myocardial ischemia caused by post-pituitary leptin, significantly increase the nutrient blood flow of the myocardium of mice, and prolong the time of cardiac arrest in hemorrhagic shock in rats. (4) The effect on the uterus: paeoniflora has a specific effect on the uterus, its glycoside on the mouse isolated uterine motility, low concentration has an excitatory effect, high concentration has an inhibitory effect. Paeoniflorin also significantly inhibit oxytocin-induced uterine contractions. (5) Sedative effect: paeoniflorin injection subcutaneous injection can significantly prolong the hypnotic time of sodium pentobarbital, its sedative effect may be due to the inhibition of the cerebral cortex. Paeonia lactiflora glucoside 1 mg / rat ventricular administration, can see a mild sedative effect, increase the amount of administration can be seen in the gradual deepening of sleep. (6) Antibacterial effect: Paeonia lactiflora decoction has an inhibitory effect on Shigella dysentery bacillus, Staphylococcus aureus, Pseudomonas aeruginosa, skin fungi. The tannin contained has antiviral effect. (7) Anti-inflammatory and antipyretic effects: Paeonia lactiflora decoction has anti-inflammatory effects on foot swelling caused by carrageenan gum and dextrose glycoside; Paeonia lactiflora extract has significant inhibitory effects on oedema in rat egg white arthritis. It has inhibitory effect on proliferation of rat cotton ball granuloma. It has significant enhancement effect on phagocytosis of reticuloendothelial system and phagocytosis of abdominal macrophages in mice. ①Anti-inflammatory effects: A. Inhibit the synthesis of local inflammatory factors including leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in arthritic rats mainly by regulating the concentration of intracellular Ca2. B. Significantly reduce fibrin exudation and inflammatory cell infiltration in the ankle joints of arthritic rats. C. Inhibit the over-secretion of PGE2, IL1, and TNFα by synovial cells. ②Immunomodulatory and Immunosuppressive effects: A. Total white peony glycosides in high concentration can inhibit the proliferative response of B lymphocytes, thus inhibiting the over-secretion of IgM and IgG antibodies by B cells. And can increase the number of specific inhibitory T cells (Ts), and improve their activity, so that the ratio of Th1/Th2 back to normal.B. Can inhibit the function of abnormally activated monocyte macrophages, inhibit their excessive secretion of IL1 and H202, so that the low IL2 back to normal; high concentration of total paeoniae lactiflora glycosides on the activation of the monocyte macrophage production of TNF α and leukotriene B4 (LTB4) has a significant inhibitory effect. ③ Scavenging excessive free radicals in the body: it can reduce excessive plasma malondialdehyde (MDA) and N02 levels, and also normalize excessive low superoxide dismutase dismutase (SOD) and glutathione peroxidase (GSHPX) activities. (4) Others: It can reduce the high level of corticosterone, adrenocorticotropic hormone and β-endorphin in stressed rats; it also has hepatoprotective effect, which can reduce the elevated alanine aminotransferase in the animal model of drug-induced hepatitis and improve the degenerated hepatocytes; it can protect the erythrocyte membrane and inhibit erythrocyte osmotic hemolytic effect. (8) Hepatoprotective effect: D aminogalactose hydrochloride-induced liver injury and SGPT elevation in rats, white peony extract has obvious protection and reduce the SGPT effect, histological examination shows that after the treatment of white peony, the lesions and necrosis of hepatocytes basically returned to normal. It also had obvious inhibitory effect on the elevation of SGPT caused by aflatoxin B1 in rats; it had obvious protective effect on the elevation of total activity of lactate dehydrogenase (SLDA) and isoenzymes in liver injury caused by aflatoxin. White peony extract can enhance the anticancer effect of mitomycin and so on. (9) Adaptation to the role of the original sample: Paeonia lactiflora extract has inhibited the decline of the content of vitamins in the adrenal glands of rats under the warm prick, can improve the tolerance of animals to high temperature, and inhibit the acetic acid-induced writhing reaction in mice. (10) Toxicity test: the toxicity of Paeonia lactiflora total glucoside is small, Paeonia lactiflora raw rat oral LD50 is 81g/kg, Paeonia lactiflora glucoside mouse intravenous LD50 is 3580mg/kg, intraperitoneal injection LD50 is 9530mg/kg (ZWC. 0957).
3.7 Pharmacokinetics of paeoniflorinThe blood concentration-time curve in rats showed a two-compartment open model, with the distribution phase t1/2α of (2.6±0.9) min and the elimination phase t1/2α of (27.4±14.4) min; that in rabbits also showed a two-compartment open model, with the distribution phase t1/2α of (5.9±2.7) min and the elimination phase t1/2α of (5.9±2.7) min. The apparent volume of distribution in dogs was (539±104) ml/kg, indicating that paeoniflorin was rapidly and widely distributed in vivo and was also eliminated rapidly. Total paeoniflorin appeared rapidly as a prototype in the urine after intravenous administration. The concentration of paeoniflorin did not change significantly after 150 min of isolated rat liver perfusion, suggesting that paeoniflorin is mainly excreted as a prototype in vivo via the kidneys, and the liver is not a metabolic organ of paeoniflorin.
3.8 Indications for the use of Paeonia lactiflora1. Mainly used in the treatment of rheumatoid arthritis, long-term application of the joint function has a certain effect on the recovery of long-term efficacy. Clinically, it is also used in other rheumatic diseases, such as systemic lupus erythematosus, dry syndrome, leukemia, ankylosing spondylitis, as well as osteoarthritis and interstitial pulmonary fibrosis.
2. Hepatoprotective: treatment of liver fibrosis in chronic viral hepatitis B, can significantly improve liver function and inhibit the progression of liver fibrosis.
3.9 Contraindications of Paeonia lactiflora total glycosidesIt is contraindicated for those who are allergic to Paeonia lactiflora and its related components.
3.10 PrecautionsThe effects of Paeonia lactiflora on pregnant and lactating women are not known in humans. Reproductive toxicity studies in animals have found no teratogenic effects of Paeonia lactiflora at doses up to 2160 mg.
3.11 Adverse effects of Paeonia lactifloraAdverse effects of Paeonia lactiflora are rare, mainly in the form of changes in stool properties, such as softening or thinning of stools, and increased frequency of stools, which are mild and do not require treatment. Other rare adverse reactions include abdominal distension, poor appetite, abdominal pain, nausea, dizziness, etc., which can be recovered after stopping the drug. There is no hepatic or renal impairment.
3.12 Dosage of Paeonia lactifloraAdults, 2 capsules (0.6g), twice or thrice daily. Recommended dosage for children is 30mg/(kg-d) in 2 divided doses in the morning and evening. For the first 3 months, 0.6 g 3 times daily is recommended, and 0.6 g twice daily is recommended for maintenance after onset of action.
3.13 Drug interactionsIt is contraindicated in cases of Yang failure, deficiency and cold. White peony total glucoside should be used with caution, classic Chinese medicine books recorded that white peony is anti-veratrum. It is recommended not to be used concurrently with preparations containing the herb veratrum.
3.14 Expert comments1. It should be taken with water after meals. A small number of patients may experience changes in stool properties at the beginning of the medication, which can be started with a small dose of 0.3g, twice a day, and increased to the regular amount after 1 week.
2. White peony total glycosides should be used with caution, classic Chinese medicine books recorded that white peony anti-quinoa. It is recommended not to use with preparations containing the herb veratrum at the same time.