Upper abdominal pain or discomfort is the main symptom of duodenal ulcer, which can be dull pain, burning pain, swelling pain, severe pain and hunger-like discomfort. It may be related to gastric acid stimulating nerve endings on the ulcer wall, and it often has the following characteristics: 1, chronic process, with a medical history of several years or 10 years; 2, periodic attacks, the attack period can be weeks or months, the remission period is also different, the attack is seasonal, mostly at the turn of autumn and winter and winter and spring; 3. Some patients have rhythmic epigastric pain related to eating, mainly hunger pain; 4. Abdominal pain can be relieved by acid inhibitors or antacids. Some cases do not have the above-mentioned typical pain, but only show symptoms of indigestion such as abdominal distension, anorexia, belching and acid regurgitation. When the above symptoms appear, it is recommended to go to the hospital as soon as possible to improve gastroscopy.