Take Metro Line 2 from Guangzhou South Railway Station and get off at Haizhu Square Station. Transfer to Metro Line 6 at the station and get off at Cultural Park Station. It takes 5 minutes to walk from Exit D to Shangxiajiu Commercial Pedestrian Street. It takes about 45 minutes.
Guangzhou South Railway Station does not have a direct subway to Shangxiajiu. If you find it difficult to transfer, you can take bus No. 288A and get off at Kangwang South Road Station. You can walk 600 meters to Shangxiajiu Commercial Pedestrian Street, which takes 1 and a half hours.