3. Oral administration of 5 ~ 20 mg/kg can inhibit the gastric damage caused by intramuscular injection of 20mg/kg5- hydroxytryptamine in guinea pigs. It has protective effect on liver damage caused by paracetamol.
4, reducing blood fat, anti-oxidation, anti-inflammation, anti-atherosclerosis, etc.
5. In 2004, curcumin was found to inhibit the activity of HIV- 1 integrase and was used in clinical trials of AIDS.
6. Anti-cancer is one of the main pharmacological activities of curcumin, and its anti-tumor effect has been repeatedly confirmed in many animal experiments, and its specific anti-cancer mechanism has become a research hotspot.
7. In 2006, researchers at the National University of Singapore found that curcumin in curry has antioxidant effect, which can inhibit the formation of amyloid plaques in the brain, thus reducing the chance of developing Alzheimer's disease. This may explain why the incidence of Alzheimer's disease in India is lower than that in the west.
August 20/kloc-August 2, researchers at George Mei Sen University found that curcumin is a broad-spectrum inhibitor to prevent a series of viruses from infecting healthy cells.
9. The effect of curcumin on cell proliferation, cell cycle regulation and apoptosis of liver cancer cells (QGY). Methods MTT assay was used to determine the inhibitory effect of curcumin on QGY at different concentrations and different time, flow cytometry was used to analyze the cell cycle distribution, and transmission electron microscope was used to observe the ultrastructural changes of cells. Results Curcumin could inhibit the growth of QGY cells, and its inhibitory rate was dependent on drug concentration and action time. The median concentration (IC50) for 72 h was 49.50μ mol/L. Flow cytometry analysis confirmed that curcumin could accumulate QGY cells in S phase, and electron microscopy observation showed that curcumin could lead to cell degeneration, necrosis and apoptosis.
10. To explore the anti-tumor mechanism of curcumin. Methods The chick chorioallantoic membrane model was used to observe the effect of curcumin on angiogenesis. Using the cultured tumor cell SMMC-772 1, the apoptosis of SMMC-772 1 induced by curcumin was observed by electron microscope and flow cytometry. Results Curcumin could obviously inhibit the angiogenesis in chick chorioallantoic membrane. 20 μmol*L- 1 curcumin can induce SMMC-772 1 cell apoptosis. Curcumin is a plant polyphenol extracted from Curcuma longa, and it is also the most important active ingredient of Curcuma longa to exert pharmacological effects. Recent studies not only prove the traditional effects of Curcuma longa, but also reveal some new pharmacological effects. Such as anti-inflammatory, anti-oxidation, scavenging oxygen free radicals, anti-human immunodeficiency virus, protecting liver and kidney, anti-fibrosis and anti-cancer, may be related to its inhibition of the activation and expression of transcription factors such as nuclear factor -κB and activator protein-1, and there is no obvious toxic side effect.
Curry is rich in content and has a good effect with chemotherapy.
Curcumin, which is rich in curry, is found to have the effect of adjuvant chemotherapy and combating prostate cancer cells. Pu Yongxiao, an attending physician in the urology department of National Taiwan University Hospital, found that curcumin can break the firewall of cancer cells and help chemical drugs drive straight into cancer cells.
Pu Yongxiao has been studying the treatment of prostate cancer and bladder cancer for a long time, and his research and teaching achievements have been deeply affirmed, and he was awarded the Green Apricot Award by the Medical College of National Taiwan University. One of Pu Yongxiao's latest studies is to use curcumin to assist chemotherapy of prostate cancer.
Pu Yongxiao said that when prostate cancer has not metastasized, it will generally be treated by surgery or electrotherapy; Metastatic prostate cancer is treated with hormone therapy, but this treatment will fail in an average of one to one and a half years. Many patients switch to chemotherapy after failure, but the effect is limited. Generally speaking, chemotherapy can only relieve symptoms, and there is no evidence that it can prolong life. Patients will die in an average of three months.
Curcumin and chemical drugs were used to treat prostate cancer cell lines. It was found that if only chemical drugs were used, the death effect of cancer cell lines was limited, but if curcumin was added, there would be an additive effect of "one plus one is greater than two". Pu Yongxiao said that curcumin is a strong antioxidant, and its own biochemical and physiological characteristics are ingenious, which can prevent cancer cells from escaping. He explained that when chemical drugs want to kill cancer cells, cancer cells will build a defense wall, so that drugs can not play a role, but curcumin can destroy this firewall and greatly increase the efficacy.
Although this research is only a preliminary result in the laboratory, Pu Yongxiao believes that curcumin is easy to obtain and readily available. If further clinical trials prove that it is effective for patients, it will be a major breakthrough in treatment.
Antitumor activity
Five fluorine-containing monocarbonyl curcumin analogues were synthesized by the reaction of fluorobenzaldehyde with ketone by active group splicing method. Their structures were confirmed by IR,~ 1H NMR and ESI-MS. The antitumor activity of the synthesized compounds was tested by MTT method. The results showed that some compounds had strong selective inhibitory activity on tumor cells, among which 2,6- bis (4- fluorophenylene) cyclohexanone (3a. 6- bis (2- fluorophenylene) cyclohexanone (3b) has a broad anti-tumor spectrum and good activity. In this regard, compound 3b was cultured in single crystal and its crystal structure was analyzed by X-ray diffraction. The structure showed that compound 3b belongs to triclinic system, with space group P- 1. The cell parameters a = 0.9222 (2) nm and b = 0.9733. c= 1.0 127(2)nm,α=88.920(4)°,β=75.672(3)°,γ=62.404(3)°,V=0.7755(3)nm~3,Z=2,D_c= 1.329 Mg·m~(-3),μ=0.097 mm~(- 1), F(000)=324, the final deviation factor R = 0.0590, WR = 0.1841.Animal experiments in Duke University in the United States show that curcumin in curry can not only decompose amyloid in the brain of experimental mice, but also prevent the production of this protein. The researchers pointed out that eating curry often may have a similar effect on people, thus helping to prevent Alzheimer's disease.
Many studies have proved that the accumulation of amyloid in the brain is one of the most important causes of Alzheimer's disease. Previous studies have shown that curcumin, the key ingredient in curry, can prevent brain nerve cell damage and improve brain nerve cell function.
According to American media reports, researchers at Duke University in the United States have genetically modified experimental mice, so that many amyloid proteins appear in their brains. The researchers then provided these experimental mice with foods rich in curcumin, and found that the amyloid in the brains of experimental mice was decomposed, and the same diet could also prevent the amyloid from appearing in the adult brains of experimental mice.
The researchers pointed out that their next step will be to determine the effect of curcumin on amyloid plaques in the human brain. In addition, they will also study the effect of eating a lot of curry to determine whether such eating habits can maximize the effectiveness of curcumin.
The researchers also hope that in the future, based on these studies, a drug with curcumin as the main component will be developed to treat Alzheimer's disease, which will achieve better curative effect than eating curry.