Table of Contents 1 Pinyin 2 National Essential Drugs 3 Haifuji yuyuxu Wan 3.1 Name 3.2 Prescription 3.3 Formulation 3.4 Properties 3.5 Identification 3.6 Inspection 3.7 Content Determination 3.7.1 Chromatographic Conditions and Systematic Suitability Tests 3.7.2 Preparation of Control Solution 3.7.3 Preparation of Supplementary Solution 3.7.4 Assay 3.8 Functions and Indications 3.9 Methods and Dosage 3.10 Precautions 3.11 Specifications 3.12 Storage 3.13 Version 4 Haifuji yuyuxu Wan 3.10 Precautions 3.11 Specifications 3.12 Storage 3.13 Version 4 Haifuyuyiyu Pill (Chinese Medicine) 4.1 Pinyin 4.2 Standard No. 4.3 Prescription 4.4 Method of Preparation 4.5 Characteristics 4.6 Examination 4.7 Functions and Indications 4.8 Methods and Dosage 4.9 Precautions 4.10 Specifications 4.11 Storage 5 Instruction of Haifuyuyu Pill (Chinese Medicine) 5.1 Name of the Medicine 5.2 Formulations 5.3 Main Ingredients of Haifuyuyu Pill 5.4 Ingredients of Haifuyuyuyu Pill (Chinese Medicine) 5.4 Functions and Indications of Haifu Byuyu Pill 5.5 Dosage and Administration of Haifu Byuyu Pill 5.6 Contraindications of Haifu Byuyu Pill 5.7 Adverse Reactions of Haifu Byuyu Pill 5.8 Precautions 5.9 Interaction of Haifu Byuyu Pill with Other Drugs 1 Phonetic Symbols

xuè fǔ zhú yū wán

2 Essential Medicines of the People's Republic of China

National essential medicines related to Haifu Byuyu Pill. Retail Guide Price Information

No. Essential Drugs

Catalog No. Name of Drug Formulations Specifications Unit Retail Guide Price

Guide Price Category Remarks 689 52 Hematopoietic Pills Honey Pills 9g Pills 0.8 Proprietary Chinese Medicines *

Note:

1. The specifications of dosage forms marked with "*" in the Remarks column of the table are representative products. The dosage form specifications are representative products.

2. The dosage form specifications marked with "△" in the Remarks column of the table and other specifications of the same dosage form are temporary prices.

3. For dosage form specifications with dosage indicated in the Remarks column, the prices of other specifications in the dosage form are calculated based on the same dosage and in accordance with the "Pharmaceutical Differential Pricing Rules".

4. The "honey pill" labeled in the column of dosage form in the table includes small honey pill and large honey pill.

Xuefu Zhuyu Wan

Xuefu Zhuyu Wan

3.2 Prescription

50g of Radix Bupleurum Chinense, 150g of Radix Angelicae Sinensis, 150g of Radix Rehmanniae Praeparata, 100g of Radix Paeoniae Alba, 150g of Radix Safflora Sinensis, 200g of Peach Kernel, 100g of Hovenia Citriodora Brancensis, 50g of Radix glycyrrhizae Materia Medica, 75g of Rhizoma Ligustici Chuanxiong, 150g of Radix Cortex Pinnatifida, 75g of Platycodon grandiflorus. 75g

3.3 Method of Preparation

The above eleven flavors, crushed into fine powder, sieve, mix well. Every 100g of powder add 110~130g of honey to make big honey pill, that is obtained.

3.4 Character

This product is brown honey pill; taste sweet, pungent.

3.5 Identification

(1) Take this product, put it under the microscope: the oil tube contains yellowish or yellowish brown streaks of secretion, diameter 8-25μm (Chaihu). Threaded conduit diameter 14 ~ 50 μm, thickened wall interconnected, like a mesh threaded conduit (Ligusticum chuanxiong). Calcium oxalate square crystals are present in thin-walled tissues in sheets (Citrus aurantium). The pollen grains are round or oval, about 60μm in diameter, with spines on the outer wall, with 3 germination holes (safflower).

(2) take 9g of this product, add 6g of diatomaceous earth, research, add 50ml of methanol, heating reflux for 60 minutes, cooling, centrifugation for 5 minutes, take the supernatant, evaporation, residue with 20ml of water to make the dissolution, add 50% ethanol 10ml and dilute hydrochloric acid 1ml, shaking, extracted by shaking with ether for 2 times, 25ml each time, combined with ether extracts (acid aqueous solution standby), washed with water. Wash with water for 2 times, 25 ml each time, discard the water washings, low temperature evaporation of ether solution, the residue of methanol 1 ml to dissolve, as a test solution. Take ferulic acid control product, add methanol to make a solution containing 1mg per 1ml, as the control solution. According to the thin layer chromatography (2010 version of Pharmacopoeia, Appendix VI B), absorb the test solution 2-6μl, control solution 2μl, respectively, point on the same silica gel G thin layer plate, toluene - ethyl acetate - formic acid (20:10:1) as the unfolding agent, unfolding, take out, air drying, spraying with the newly prepared 1% ferric chloride solution and 1% ferric iron solution, then sprayed with a new 1% ferric iron solution. Remove, dry, spray with a freshly prepared mixture of 1% ferric chloride solution and 1% potassium ferricyanide solution in equal amounts, and examine under daylight. Test chromatogram, in the corresponding position with the control chromatogram, the same color spots.

(3) take [identification] (2) under the standby acid solution, ethyl acetate shaking extraction 2 times, each time 25 ml, combined with ethyl acetate extract (acid solution standby), washed with water for 2 times, each time 25 ml, discarding the water wash solution, ethyl acetate solution evaporated, the residue of 1 ml of methanol to make dissolved, as a solution of the test material. Take Hovenia Citrus control 1g, add methanol 10ml, ultrasonic treatment for 10 minutes, filtration, filtrate as a control solution. Then take naringin control, add methanol to make a solution containing 1mg per 1ml, as the control solution. According to the thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 2~4μl of the test solution, 2μl each of the control herbal solution and the control solution, respectively, spot on the same high-performance silica gel G thin-layer plate, with trichloromethane-methanol-water (13:6:2) of the lower solution as the unfolding agent, unfolding, removing, drying, spraying with 5% of 5% of naringenin, then spraying with 5% of methanol. dry, sprayed with 5% aluminum trichloride ethanol solution, heated at 105 ℃ for 10 minutes, and examined under ultraviolet light (365 nm). In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb and the chromatogram of the control article, the fluorescent spots of the same color.

(4) take [identification] (3) under the standby acid aqueous solution, water saturated n-butanol vibration extraction 2 times, 20 ml each time, combined with n-butanol extract, take half of the n-butanol solution (the remaining amount of standby), washed with ammonia solution 2 times, 20 ml each time, discard the ammonia wash solution, the n-butanol solution evaporated, the residue of the addition of methanol 1 ml to make the dissolution of, as a test solution. Take 1g of the control herb of hyssop, add 25ml of 50% methanol, heat and reflux for 1 hour, cool, filter, add 20ml of water to the filtrate, extract with water saturated with n-butanol by shaking for 2 times, 25ml each time, combine the n-butanol extracts, washed with n-butanol saturated with water for 2 times, 25ml each time, discard the aqueous washings, evaporation of the n-butanol solution, residue with 1ml of methanol to make it dissolved, as a solution of the control herb. Then take β ecdysterone control and paeoniflorin control, respectively, add methanol to make a solution containing 1 mg per 1 ml, as the control solution. According to the thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 4-10 μl of the test solution, 6 μl of the control solution and 2 μl of each of the control solution, and then dispense them on the same silica gel GF254 thin-layer plate, and then analyze the results with the solution of trichloromethane-ethyl acetate-methanol-concentrated ammonia (2:4:8), and then add methanol to make 1 mg of each solution. test solution (2:4:8:1) as the unfolding agent, unfold, remove, dry, and examine under ultraviolet light (254nm). In the chromatogram of the test article, spots of the same color are shown in the corresponding positions with the chromatogram of the control herb and the chromatogram of β ecdysterone control article. Spray with 5% vanillin sulfuric acid solution, heat until the spots show clear color, and examine under daylight. In the chromatogram of the test product, in the position corresponding to the chromatogram of paeoniflorin control product, the same color spots.

(5) take [identification] (4) under the remaining n-butanol extract, washed with water twice, each time 20 ml, discard the water wash solution, n-butanol solution evaporated, the residue of 1 ml of methanol to make dissolved, as a test solution. Another take glycyrrhiza glabra control herb 1g, add ether 40ml, heating reflux for 1 hour, filtration, dregs add methanol 30ml, heating reflux for 1 hour, filtration, filtrate evaporation, residue add water 40ml to make dissolved, extracted by shaking with n-butanol for 3 times, 20ml each time, combined with n-butanol extract, washed with water for 3 times, 20ml each time, discarding the aqueous washings, evaporation of the n-butanol, residue add methanol 1ml to make dissolved, as a control solution. The residue was dissolved with 1 ml of methanol and used as the control herb solution. According to the thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 2-6μl of the test solution, 1μl of the control solution, were spotted on the same high-performance silica gel G thin-layer plate, ethyl acetate - glacial acetic acid - formic acid - water (15:1:1:2) as an unfolding agent, unfold, remove, dry, and then remove. Expand, remove, dry, sprayed with 10% ethanol sulfate solution, heated at 105 ℃ until the spots showed clear color, and examined under ultraviolet light (365 nm). In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the fluorescent spots of the same color.

(6) take 9g of this product, add 6g of diatomaceous earth, research, add 50ml of methanol, heat reflux for 60 minutes, cooling, centrifugation for 5 minutes, take the supernatant, decompression recovery of solvents and evaporation, the residue add 7% ethanol sulfate solution - water (1:3) mixture of 20 ml, placed in a water bath and heat reflux for 3 hours, cooling, shaking with chloromethane. Extract 2 times, each time 20 ml, combined trichloromethane extract, washed with water 2 times, each time 20 ml, discard the water washings, trichloromethane solution with an appropriate amount of anhydrous sodium sulfate dehydration, filtration, filtrate evaporation, residue with methanol 1 ml to make dissolved, as a test solution. Take 1g of control herb of Platycodon grandiflorus, add 7% ethanol sulfate solution - water (1:3) mixture of 20ml, the same method into the control herb solution. According to thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 2-6 μl of the test solution, 4 μl of the control solution, were spotted on the same silica gel GF254 thin-layer plate, trichloromethane - ether (2:1) as an unfolding agent, unfolding, take out, drying, and examined under ultraviolet light (254nm). In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, show the same color spots. Then sprayed with 10% sulfuric acid ethanol solution, heated at 105 ℃ until the spots show clear color, and examined under sunlight. In the chromatogram of the test product, in the corresponding position with the chromatogram of the control herb, the same color spots.

3.6 Inspection

It should comply with the relevant provisions under pills (2010 version of Pharmacopoeia I Appendix VI A).

3.7 Determination of content

Determined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI D).

3.7.1 Chromatographic conditions and system suitability test

Octadecylsilane-bonded silica gel as filler; 70% acetonitrile as mobile phase A, 0.1% phosphoric acid solution as mobile phase B; paeoniflorin detection wavelength of 230 nm, naringenin detection wavelength of 283 nm; the theoretical number of plates according to the peak of paeoniflorin should not be less than 5000.

? Time (min) ? Mobile phase A (%) ? Mobile phase B (%) ?0~25 ?24→40 ?76→60 ?25~26 ?40→100 ?60→0 ?26~30 ?100 ?0 3.7.2 Preparation of control solution

Take appropriate amount of paeoniflorin control and naringenin control, weigh it precisely, and make a mixture of 30μg of paeoniflorin and 45μg of naringenin in every 1ml by adding 70% ethanol, which is obtained.

3.7.3 Preparation of test solution

Take the product under the weight difference, cut, mix, take about 1.0g, precision weighing, precision add 70% ethanol 50ml, weighing, placed on a water bath heating reflux for 45 minutes, cooled, then weighing, 70% ethanol to make up for the loss of weight, shaking, centrifugation (speed of 3,000 revolutions per minute) for 5 minutes, take the supernatant. The supernatant was taken and obtained.

3.7.4 Determination method

Precision aspiration of the control solution and test solution of 10μl each, injected into the liquid chromatograph, measurement, that is, obtained.

Each pill of this product contains not less than 4.0mg of Paeonia lactiflora lactiflora (C23H28O11), and not less than 8.7mg of Citrus aurantium glutinosa (Naringenin) (C27H32O14).

3.8 Functions and Indications

Promoting blood circulation to eliminate blood stasis, promoting qi and relieving pain. It is used for chest pain caused by stagnation of qi and blood stasis, headache for a long time, pain like pins and needles with a fixed place, internal heat and boredom, palpitation and insomnia, impatience and irritability.

3.9 Dosage and Administration

Take with brown sugar water on an empty stomach. Take 1 to 2 pills at a time, twice a day.

3.10 Caution

Avoid eating cold and spicy food; prohibited for pregnant women.

3.11 Specifications

Each pill weighs 9g

3.12 Storage

Sealed.

3.12 Storage

Sealed. 3.13 Version

Second Supplement to Chinese Pharmacopoeia of 2010

4 Blood Fu Zhuyu Wan (血府逐瘀丸), Ministry of Traditional Chinese Medicine (MTM) 4.1 Pinyin

Xuefu Zhuyu Wan

4.2 Standard Number

WS3B007189

4.3 Prescription

Bupleurum Chinense ( 柴胡), 50g of angelica sinensis (当归), 150g of dihuang (地黄), 150g of ibupleurum chinense (赤芍), 150g of peach kernel (桃仁) 200g of red peony (芍) 100g Safflower 150g Peach kernel 200g Citrus aurantium dulcis (fried with bran) 100g Licorice 50g Rhizoma Ligustici Chuanxiong 75g Radix Achyranthis Bidentatae 150g Platycodon Grandiflorus 75g

4.4 Method of Preparation

The above eleven flavors are crushed into fine powder, sifted, and mixed well. Every 100g of powder add 110-130g of honey to make big honey pills, that is obtained.

4.5 Properties

This product is brown honey pills; taste sweet, pungent.

4.6 Inspection

It should comply with the relevant provisions under pills (Appendix 2).

4.7 Functions and Indications

Promoting blood circulation to dispel blood stasis, promoting circulation of Qi and relieving pain. It is used for internal obstruction of blood stasis, headache or chest pain, internal heat and dizziness, insomnia, palpitation, palpitation and anxiety, impatience and anger.

4.8 Dosage and Administration

On an empty stomach, take 1 to 2 pills with brown sugar water, twice a day.

4.9 Precautions

Avoid eating cold and pungent food. Pregnant women should not take.

4.10 Specifications

Each pill weighs 9g

4.11 Storage

Sealed.

5 Directions for Blood Capital and Blood Stasis Relieving Pill 5.1 Name of the medicine

Blood Capital and Blood Stasis Relieving Pill

5.2 Formulations

Large honey pill: each pill weighs 9g.

5.3 Main ingredients of Blood Capital and Blood Stasis Relieving Pill

Bupleurum Chinense, Radix Angelicae Sinensis, Radix Rehmanniae Praeparata, Radix Paeoniae Lactiflora, Rhizoma Safflorae, Rhizoma Polygonati Odorati, Radix Polygoni Multiflori, Rhizoma Polygonati Odorati, Rhizoma Platycodon Grandiflori and so on.

5.4 Functions and Indications of Hematopoietic Pill

Promoting blood circulation, eliminating blood stasis, promoting Qi circulation and relieving pain. It is used in treating headache or chest pain due to internal obstruction of blood stasis, internal heat and dizziness, insomnia, palpitation, palpitation and dizziness, impatience and anger.

5.5 Usage and dosage of Hematopoietic Pills

On an empty stomach, take 1~2 pills with brown sugar water, 2 times a day.

5.6 Contraindications of Hematopoietic Pills

Contraindicated for pregnant women.

5.7 Adverse effects

Unknown.

5.8 Precautions

1. Avoid tobacco, alcohol, spicy, fishy food.

2. It is not advisable to take tonic Chinese medicine at the same time.

3. Diabetic patients and people with high blood pressure, heart disease, liver disease, kidney disease and other chronic diseases should take under the guidance of a physician.

4. Children, pregnant women, lactating women, the elderly and weak, spleen deficiency and loose stools should be taken under the guidance of a physician.

5. If the symptoms are not relieved after 3 days of taking the medicine, you should go to the hospital.

6. Allergic to the product is prohibited, allergic people should be cautious.

7. The use of this product is prohibited when the properties of the product have changed.

8. Children must be used under adult supervision.

9. Keep this product out of the reach of children.

10. If you are using other drugs, consult your physician or pharmacist before using this product.

5.9 Drug interactions