Function:
(1) pressor, cardiotonic and anti-shock effects "Research on Chinese Patent Medicines" (1983; 2.26): The hypotensive state of anesthetized rabbits was used as a model to observe the effects of Sini Decoction and its single components. Results: Although single aconite root has certain cardiotonic effect, its effect is not as good as Sini decoction, and it can cause ectopic arrhythmia. Single licorice can not increase the amplitude of cardiac contraction, but it has a pressor effect; Single dried ginger failed to show any meaningful physiological effects. Sini decoction, which is composed of three medicines, has better effect of strengthening heart and boosting blood pressure than other medicine groups, and can slow down sinus heart rate and avoid ectopic arrhythmia caused by single aconite root, suggesting the rationality of the compound prescription, and also reflecting the scientific nature of the Chinese medicine saying that "aconite root is not hot without dried ginger, but licorice root is slow". New Journal of Medicine (1974; 3.21): It is observed that Sinitang injection has the following effects by intramuscular or intravenous injection:1. When the systolic blood pressure of cardiogenic shock is 80-60 mm Hg, the blood pressure rises to 90- 1 10/60-90 mm Hg after120 minutes after injection, which is characterized by mild action and no longer rises when the blood pressure returns to normal. When the blood pressure drops to zero in severe shock, it can be boosted by western medicine first, and then maintained by Sini decoction. 2. Improve microcirculation. For patients with cold limbs, pale lips and blue skin, the limbs will warm up first after taking the medicine, which indicates that the visceral blood perfusion may be improved in quality and dynamics. The heart rate generally does not decrease, but the strength increases, the heart sound is strong, and the pulse is strong. 3. Prevent the occurrence of shock. Sinitang injection has been proved to have this effect in practice, and its cardiotonic effect is obvious. In a word, it is considered that Sinitang injection can not only raise blood pressure, but also improve microcirculation, and has the effects of strengthening the heart and calming down. "Chinese patent medicine research poverty" (1985; 9: 24): This prescription has obvious antagonistic effects on hemorrhagic shock, pure hypoxic shock, embolic shock caused by olive oil and cardiogenic shock caused by coronary artery ligation. It also has a significant cardiotonic effect, which can increase the coronary flow and improve the abnormal ECG caused by hypoxia. It can also stimulate the function of pituitary-adrenal cortex, and has central analgesic and sedative effects, and the prescription is not toxic. Journal of traditional chinese medicine (1982; L1:73): Intestinal perfusion with Sini decoction has therapeutic effect on rabbits with primary mesenteric artery occlusion shock and late hemorrhagic shock with secondary small intestinal ischemia injury.
② Toxicity Study Journal of Pharmacy (1966; 5: 35): Studies show that the co-cooking of licorice, dried ginger and cooked aconite reduces the toxicity of aconite. The LD 50 of a single cooked aconite was 3.56±0.409g/kg/kg by intraperitoneal injection and17.4210.24 g/kg by oral administration, while the LD 50 of Sini decoction was 5.8210.599 g/kg respectively. The ECG changes of single aconite poisoning are similar to aconitine poisoning, but there is no abnormal change in ECG when the same dose of aconite is used to form Sini decoction. In addition, the isolated toad venom heart was studied, and the results showed that the toxic effect of aconite was reduced by 30 times in Sini decoction. ③ The bactericidal effect was published in journal of traditional chinese medicine (1962; 1o:18): The experiment proves that Sini decoction not only has no bactericidal effect, but can promote the growth of flora. However, the prescription plus Radix Astragali and Radix Codonopsis combined with blood transfusion and infusion has achieved good results in the treatment of Staphylococcus aureus septicemia with yang deficiency. To this end, it is emphasized that the treatment must first be "dialectical".