Gynostemma pentaphyllum is distributed in China, Japan, South Korea, India and Southeast Asia. Jiangsu, Zhejiang, Anhui, Jiangxi, Fujian, Taiwan Province, Hubei, Hunan, Guangdong, Guangxi, Sichuan, Guizhou, Yunnan, Tibet, Shaanxi, Henan and other provinces (autonomous regions) south of the Yangtze River are all distributed, and most of them are wild. Now it is cultivated in Guizhou, Guangxi, Sichuan and Yunnan.