The United States successfully transplanted two pig kidneys for a brain-dead person. According to foreign media reports, the successful transplantation of pig kidney into human body for the first time will hopefully solve the global organ shortage crisis. The United States successfully transplanted two pig kidneys for a brain-dead person.

The United States successfully transplanted two pig kidneys for a brain-dead person on June1June 65438+1October 2 1 day. According to foreign media reports, after David Bennett became the first patient in the world to receive a genetically modified pig heart transplant, American doctors announced that they had successfully transplanted two pigs into a brain-dead human body, which marked another step forward in the xenotransplantation technology of using animal organs to save lives.

Jim Parsons, a 57-year-old from Huntsville, Alabama, fell into a state of brain death in a cross-country cycling race in September, 20021. With the support of his family, researchers at the University of Alabama in Birmingham performed a groundbreaking transplant for Parsons only four days later.

Parsons' own kidney was removed while the blood was still circulating, and then he was transplanted with two organs from genetically modified pigs. The transplanted pig kidney can filter blood, produce urine, and more importantly, there is no rejection. Both organs survived for three days after transplantation.

The results show that xenotransplantation may help solve the global organ shortage crisis. Because pig heart is similar to human organs in function and physiological structure, it is used as a model for developing new therapies. The first peer-reviewed study of Parsons' successful pig kidney transplantation by doctors at the University of Alabama in Birmingham was published in the American Journal of Transplantation on Thursday.

Professor Jim Locke, director of the Institute of Surgical Comprehensive Transplantation at the University of Alabama in Birmingham and the chief surgeon of this study, said: "This is a time to change the rules of the game in the history of medicine and an important milestone in the field of xenotransplantation. Xenotransplantation can be said to be the best solution to the organ shortage crisis. We filled the key knowledge gaps and obtained the safety and feasibility data needed to start clinical trials in living people with end-stage renal failure. This research provides knowledge that animal models cannot produce, which brings us one step closer to the future when organ supply meets huge demand. "

It is reported that Parsons is keen on riding cross-country bicycles, but an accident occurred while riding in the Woods on September 26 last year, which led to his brain death, and he received a transplant operation on September 30. Professor Locke said: "maintaining blood circulation was originally to support transplanted organs, and then for our research."

Parsons is a registered organ donor of Hope Heritage, an organ purchasing organization in Alabama. He is eager to help others after his death, but his organs are not suitable for donation. His family allowed the University of Alabama in Birmingham to continue to use the ventilator during the study to maintain Parsons' normal physical function.

Parsons' ex-wife Julie O 'Hara said: "Parsons will want to save as many people as possible with his death. If he knew that it might save thousands of people, he would not hesitate to do so. Our dream is that no one else will die for the kidney. We know Parsons will be very proud because his death may bring more hope to others. "

Parsons' transplanted pig kidneys are taken from donated pigs raised in pathogen-free and surgical-grade facilities, and then stored, transported and processed for implantation, just like human kidneys. Before the operation, Parsons conducted a cross-matching test with the donor animals to determine whether the transgenic organs matched their tissues well. Every human kidney transplant will be cross-matched. However, this tissue matching test between pigs and humans was developed by the University of Alabama in Birmingham, marking the first time that the prospective cross-matching between the two species has been verified.

Pig kidney is placed in the precise anatomical position used by human donor kidney, and is connected with renal artery, renal vein and ureter that transports urine from kidney to bladder. Parsons also received standard immunosuppressive therapy, in other words, therapy to reduce the activity of the human immune system.

When asked about the transplant effect of healthy patients compared with brain-dead patients, Professor Locke said that the process would not be different, but the results would be different. She said: "The state of brain death is very bad, and it is difficult to evaluate renal function (such as urine volume and creatinine clearance rate), which is not surprising, because even in human-to-human transplantation, the kidneys of brain-dead donors usually delay the transplantation function, which means that these kidneys usually do not urinate for a week and it takes several weeks to clear creatinine."

According to the surgical team, their process proved the long-term feasibility of this transplant and how it might work in the real world. Professor Locke said: "This human preclinical model is a method to evaluate the safety and feasibility of the pig-to-non-human primate model, and it will not pose a risk to the living. Our research shows that the main obstacles of human xenotransplantation have been overcome, and we have determined where new knowledge is needed to optimize the results of human xenotransplantation, and laid the foundation for establishing a new preclinical human model for further research. "

Transplanting pig organs into human body is expected to increase the number of organs available for transplantation and avoid the death of a large number of patients every year due to organ shortage. According to statistics, at present, more than 800,000 Americans suffer from renal failure. Because there are few organs available, most people are never on the waiting list for transplantation.

The United States successfully transplanted two pig kidneys for a brain-dead person. Recently, medical experts have made many breakthroughs in the field of xenotransplantation. Genetically edited pig kidneys and pig hearts have been transplanted into human patients, and the results are not bad.

According to foreign media reports, a study published in the American Journal of Transplantation by experts from the University of Alabama at Birmingham pointed out that the successful transplantation of pigs into human bodies for the first time will hopefully solve the global organ shortage crisis.

Previously, experts from Langone Medical Center of new york University had conducted experiments on transplanting transgenic pig kidneys into human bodies, but all of them were carried out on brain-dead patients.

However, both transplants were performed in vitro, connecting the pig kidney with the patient's thigh blood vessels. But in the end, all the operations were successful, and no rejection was found during the study, which indirectly proved the feasibility of this xenotransplantation.

Now, scientists at the University of Alabama have completed another pioneering work, successfully transplanting pigs into patients. During the monitoring period of 77 hours after operation, the kidney was able to filter blood, and the urine volume and creatinine level were relatively normal, and no rejection occurred.

Researchers say that one of the pig's genes was edited during a kidney transplant in new york University. In their transplantation, 10 kinds of key genes were edited in pigs, which made pig kidney more suitable for transplantation into human body and prevented rejection.

Because the pig's organs are about the same size as the human body, and they are easier to reproduce. Reducing the immune rejection of organ xenotransplantation by editing pig genes will help thousands of patients facing organ failure.

It is worth mentioning that recently, a surgeon at the University of Maryland Medical Center in the United States said that a 57-year-old heart patient had just undergone a genetically modified pig heart transplant, and the patient was in good condition after the operation.

The United States successfully transplanted two pig kidneys for a brain-dead person. According to foreign media reports in 654381October 20th, the United States completed the world's first operation to transplant two kidneys of transgenic pigs into human body. Doctors hope that this method can solve the organ shortage crisis. Jim Parsons, a brain-dead patient with acute kidney injury, is totally supported by artificial life system and has no hope of recovery.

Dr Jamie Locke of the University of Alabama in Birmingham said: "With the development of medicine, it is time to change the rules of the game. We should learn to accept the change of mode. This operation is an important milestone in the field of xenotransplantation and can be said to be the best solution. At present, the key knowledge gaps have been filled, and the safety and feasibility data needed to start clinical trials in patients with advanced renal failure have been obtained. "

Porcine heart valves have been widely used in humans. Earlier this month, 57-year-old David Bennett became the first person in the world to have a pig heart. Xenotransplantation-transplanting animal organs into human body-has been the goal of scientists for many years. Dr. Locke said: "The research shows that the main obstacles of human xenotransplantation have been overcome, and the new knowledge needed to optimize the results of human xenotransplantation has been determined, which lays the foundation for further research and establishment of new preclinical human models."

It is reported that 57-year-old Parsons is a registered organ donor, and he underwent four hours of surgery with the consent of his family. After the pig kidney was implanted in its body, the blood and urine were filtered, and there was no immediate rejection, and it was still working 77 hours after transplantation. Parsons wants to donate organs after death, but it is not suitable. Before his kidney was removed and replaced by pig kidney, Parsons relied on a ventilator to maintain his body function.

Parsons' family said, "He is a very kind person and never makes enemies. Parsons agreed to participate in this experiment this time because he wanted to save as many people as possible with his own sacrifice. I hope no one will die waiting for organ donation in the future We know that Parsons will be very proud and his contribution is worthwhile. "

In the United States, there are nearly/kloc-0.07 million people waiting for organ transplantation, most of whom need kidneys, and the average waiting time is 3 to 5 years. There are about 7,000 people on the British list, more than half of whom need kidneys. Last year alone, more than 470 people died while waiting for organs. The researchers said: "Xenotransplantation has a long way to go to become the main treatment."