Yes. Since fresh Enoki mushrooms contain colchicine, after humans eat them, they can easily produce toxic colchicine due to oxidation, which has a strong stimulating effect on gastrointestinal mucosa and respiratory mucosa. Generally, symptoms such as dry throat, nausea, vomiting, abdominal pain, and diarrhea will occur within 30 minutes to 4 hours of consumption; after consumption in large quantities, it may also cause serious symptoms such as fever, disordered water and electrolyte balance, blood in the stool, and blood in the urine.

Colchicine is easily soluble in water and can be destroyed after sufficient heating. Therefore, before eating fresh enoki mushrooms, they should be soaked in cold water for 2 hours; when cooking, boil the enoki mushrooms until they are soft and cooked. Alkali decomposes when exposed to heat; when it is served cold, in addition to soaking it in cold water, it is also necessary to blanch it in boiling water to let it cook thoroughly. In addition, the colchicine in dried or canned enoki mushrooms sold on the market has been destroyed and can be eaten with confidence.

However, enoki mushrooms are not suitable for everyone. Traditional medicine believes that enoki mushrooms are cold in nature, and people with cold spleen and stomach and chronic diarrhea should eat less; patients with arthritis and lupus erythematosus should also eat with caution to avoid aggravating their condition